{"id":46052,"date":"2026-04-22T16:53:48","date_gmt":"2026-04-22T14:53:48","guid":{"rendered":"https:\/\/semaxpolska.com\/?p=46052"},"modified":"2026-04-16T17:02:29","modified_gmt":"2026-04-16T15:02:29","slug":"jakie-dawki-peptydu-miedziowego-ghk-cu-byly-stosowane-w-badaniach-na-zwierzetach-i-u-ludzi","status":"publish","type":"post","link":"https:\/\/bioevidencehub.com\/cs\/jakie-dawki-peptydu-miedziowego-ghk-cu-byly-stosowane-w-badaniach-na-zwierzetach-i-u-ludzi\/","title":{"rendered":"Jakie dawki peptydu miedziowego (GHK-Cu) by\u0142y stosowane w badaniach na zwierz\u0119tach i u ludzi?"},"content":{"rendered":"

D\u00e1vkov\u00e1n\u00ed peptid\u016f m\u011bdi (GHK-Cu) ve studi\u00edch na zv\u00ed\u0159atech a lidech<\/h2>\n

D\u00e1vky peptidu m\u011bdi pou\u017e\u00edvan\u00e9 ve v\u00fdzkumu se zna\u010dn\u011b li\u0161\u00ed v z\u00e1vislosti na v\u00fdzkumn\u00e9m modelu a zp\u016fsobu pod\u00e1n\u00ed. Ve studi\u00edch na zv\u00ed\u0159atech se obvykle pou\u017e\u00edv\u00e1 rozmez\u00ed mikrogram\u016f a\u017e miligram\u016f na kilogram t\u011blesn\u00e9 hmotnosti, zat\u00edmco ve studi\u00edch na lidech p\u0159eva\u017euje lok\u00e1ln\u00ed aplikace nebo n\u00edzk\u00e1 syst\u00e9mov\u00e1 expozice sp\u00ed\u0161e ne\u017e p\u0159esn\u011b definovan\u00e9 vnit\u0159n\u00ed d\u00e1vky. Ve studi\u00edch na zv\u00ed\u0159atech byl peptid m\u011bdi pod\u00e1v\u00e1n mimo jin\u00e9 intraperitone\u00e1ln\u00ed injekc\u00ed, lok\u00e1ln\u00ed aplikac\u00ed nebo pomoc\u00ed biomateri\u00e1l\u016f. Uv\u00e1d\u011bn\u00e9 experiment\u00e1ln\u00ed d\u00e1vky se nej\u010dast\u011bji pohybuj\u00ed v rozmez\u00ed p\u0159ibli\u017en\u011b 0,5 mg\/kg a\u017e 10 mg\/kg v n\u011bkolika re\u017eimech pod\u00e1n\u00ed. N\u011bkter\u00e9 mechanistick\u00e9 studie tak\u00e9 odhaduj\u00ed celkovou denn\u00ed expozici na 100-200 mg na cel\u00e9 t\u011blo (Pickart et al., 2014). V lok\u00e1ln\u00edch studi\u00edch na zv\u00ed\u0159atech se peptid m\u011bdi obvykle pou\u017e\u00edv\u00e1 v n\u00edzk\u00fdch koncentrac\u00edch ve formulac\u00edch, kter\u00e9 p\u016fsob\u00ed sp\u00ed\u0161e lok\u00e1ln\u011b ne\u017e syst\u00e9mov\u011b. Tento p\u0159\u00edstup je b\u011b\u017en\u00fd u model\u016f ran a pop\u00e1lenin, kde je peptid dod\u00e1v\u00e1n prost\u0159ednictv\u00edm syst\u00e9m\u016f, jako jsou liposomy, hydrogely nebo scaffoldy, kter\u00e9 podporuj\u00ed regeneraci tk\u00e1n\u00ed (Wang et al., 2017; Zhou et al., 2021).<\/p>\n

V lidsk\u00fdch studi\u00edch je d\u00e1vkov\u00e1n\u00ed m\u00e9n\u011b standardizovan\u00e9 a nej\u010dast\u011bji se t\u00fdk\u00e1 topick\u00fdch nebo kosmetick\u00fdch aplikac\u00ed. V klinick\u00fdch studi\u00edch hojen\u00ed ran, jako jsou diabetick\u00e9 v\u0159edy, byl m\u011b\u010fnat\u00fd peptid aplikov\u00e1n p\u0159\u00edmo na posti\u017een\u00e1 m\u00edsta, nikoli syst\u00e9mov\u011b. Z tohoto d\u016fvodu je obt\u00ed\u017en\u00e9 p\u0159\u00edmo porovn\u00e1vat d\u00e1vky mezi studiemi (Mulder et al., 1994). Nov\u011bj\u0161\u00ed metody pod\u00e1v\u00e1n\u00ed, jako jsou mikrojehli\u010dky nebo intraderm\u00e1ln\u00ed syst\u00e9my, prok\u00e1zaly, \u017ee m\u011b\u010fnat\u00fd peptid je z t\u011bla pom\u011brn\u011b rychle odstra\u0148ov\u00e1n, co\u017e znamen\u00e1, \u017ee pro udr\u017een\u00ed \u00fa\u010dinku jsou nutn\u00e9 opakovan\u00e9 aplikace nebo syst\u00e9my s \u0159\u00edzen\u00fdm uvol\u0148ov\u00e1n\u00edm (Li et al., 2015). Naz\u00e1ln\u00ed a injek\u010dn\u00ed pod\u00e1n\u00ed byly zkoum\u00e1ny p\u0159ev\u00e1\u017en\u011b v preklinick\u00fdch modelech, zejm\u00e9na neurologick\u00fdch, ale pro tyto metody neexistuj\u00ed standardizovan\u00e9 d\u00e1vkovac\u00ed re\u017eimy pro lidi.<\/p>\n

Z mechanistick\u00e9ho pohledu prom\u011bnlivost d\u00e1vkov\u00e1n\u00ed vypl\u00fdv\u00e1 ze zp\u016fsobu, jak\u00fdm m\u011bd\u011bn\u00fd peptid v t\u011ble p\u016fsob\u00ed. Je rychle metabolizov\u00e1n, siln\u011b v\u00e1\u017ee m\u011b\u010f a p\u016fsob\u00ed prim\u00e1rn\u011b lok\u00e1ln\u011b v tk\u00e1n\u00edch, nam\u00edsto toho, aby vy\u017eadoval vysok\u00e9 krevn\u00ed koncentrace. Z tohoto d\u016fvodu se \u00fa\u010dinnosti \u010dasto dosahuje v m\u00edst\u011b aplikace, nikoli vysok\u00fdmi syst\u00e9mov\u00fdmi d\u00e1vkami. M\u011bd\u011bn\u00fd peptid pou\u017e\u00edvan\u00fd ve v\u00fdzkumu je dostupn\u00fd prost\u0159ednictv\u00edm dodavatel\u016f, jako je SemaxPolska. Je d\u016fle\u017eit\u00e9 zd\u016fraznit, \u017ee d\u00e1vky pou\u017e\u00edvan\u00e9 ve studi\u00edch na zv\u00ed\u0159atech a v experimentech nep\u0159edstavuj\u00ed vod\u00edtko pro bezpe\u010dnost nebo \u00fa\u010dinnost u lid\u00ed, proto\u017ee standardn\u00ed klinick\u00e9 d\u00e1vkov\u00e1n\u00ed je\u0161t\u011b nebylo stanoveno.<\/p>\n

Jakie st\u0119\u017cenia peptydu miedziowego by\u0142y stosowane w badaniach kosmetycznych?<\/strong><\/h2>\n

V kosmetick\u00fdch a dermatologick\u00fdch studi\u00edch se m\u011bd\u011bn\u00fd peptid obvykle pou\u017e\u00edv\u00e1 v n\u00edzk\u00fdch koncentrac\u00edch v topick\u00fdch p\u0159\u00edpravc\u00edch. Nej\u010dast\u011bji se pohybuj\u00ed od p\u0159ibli\u017en\u011b 0,01%do 0,1%, a\u010dkoli v n\u011bkter\u00fdch formulac\u00edch nebo v\u00fdzkumn\u00fdch studi\u00edch byly pou\u017eity koncentrace bl\u00ed\u017ee 0,4%. V kontrolovan\u00fdch studi\u00edch na lidech zam\u011b\u0159en\u00fdch na st\u00e1rnut\u00ed a regeneraci k\u016f\u017ee byly tyto p\u0159\u00edpravky obvykle aplikov\u00e1ny dvakr\u00e1t denn\u011b po dobu 8 a\u017e 12 t\u00fddn\u016f. Tyto studie uk\u00e1zaly zlep\u0161en\u00ed tlou\u0161\u0165ky k\u016f\u017ee, elasticity a sn\u00ed\u017een\u00ed viditelnosti vr\u00e1sek (Pickart & Margolina, 2018; Badenhorst et al., 2016). Ve studi\u00edch s kontroln\u00ed skupinou vedlo pou\u017eit\u00ed m\u011bd\u011bn\u00e9ho peptidu k m\u011b\u0159iteln\u00e9mu zlep\u0161en\u00ed kvality k\u016f\u017ee bez v\u00fdznamn\u00e9 syst\u00e9mov\u00e9 absorpce, co\u017e potvrzuje jeho lok\u00e1ln\u00ed \u00fa\u010dinek.<\/p>\n

P\u0159edchoz\u00ed studie rovn\u011b\u017e uk\u00e1zaly, \u017ee i n\u00edzk\u00e9 koncentrace m\u011bd\u011bn\u00fdch peptid\u016f mohou stimulovat remodelaci k\u016f\u017ee. D\u016fvodem je, \u017ee m\u011bd\u011bn\u00fd peptid p\u016fsob\u00ed jako sign\u00e1ln\u00ed molekula, kter\u00e1 iniciuje biologick\u00e9 procesy, nam\u00edsto aby vykazoval jednoduch\u00fd vztah mezi d\u00e1vkou a \u00fa\u010dinkem, typick\u00fd pro mnoho l\u00e1tek (Reddy et al., 2012). Studie penetrace k\u016f\u017e\u00ed ukazuj\u00ed, \u017ee m\u011bd\u011bn\u00fd peptid m\u016f\u017ee proniknout stratum corneum a dos\u00e1hnout hlub\u0161\u00edch vrstev, kde ovliv\u0148uje opravn\u00e9 procesy i p\u0159i n\u00edzk\u00fdch koncentrac\u00edch (Hostynek et al., 2010).<\/p>\n

Z mechanistick\u00e9ho hlediska jsou ni\u017e\u0161\u00ed koncentrace \u00fa\u010dinn\u00e9, proto\u017ee m\u011bd\u011bn\u00fd peptid reguluje genovou aktivitu, podporuje produkci kolagenu a ovliv\u0148uje antioxida\u010dn\u00ed dr\u00e1hy, m\u00edsto aby vy\u017eadoval vysokou celkovou expozici. Je v\u0161ak d\u016fle\u017eit\u00e9 si uv\u011bdomit, \u017ee rozd\u00edly ve formulac\u00edch, syst\u00e9mech dod\u00e1v\u00e1n\u00ed a n\u00e1vrz\u00edch studi\u00ed mohou ovlivnit v\u00fdsledky, co\u017e zt\u011b\u017euje jejich p\u0159\u00edm\u00e9 srovn\u00e1n\u00ed. M\u011bd\u011bn\u00fd peptid pou\u017e\u00edvan\u00fd ve studi\u00edch a formulac\u00edch je k dispozici prost\u0159ednictv\u00edm dodavatel\u016f, jako je SemaxPolska. Koncentrace pou\u017e\u00edvan\u00e9 v kosmetick\u00fdch studi\u00edch by nem\u011bly b\u00fdt pova\u017eov\u00e1ny za rovnocenn\u00e9 l\u00e9ka\u0159sk\u00fdm d\u00e1vk\u00e1m a prezentovan\u00e9 v\u00fdsledky nep\u0159edstavuj\u00ed potvrzen\u00e9 terapeutick\u00e9 \u00fa\u010dinky.<\/p>\n

Odkazy<\/h4>\n
    \n
  • Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014). GHK a DNA: Resetov\u00e1n\u00ed lidsk\u00e9ho genomu ke zdrav\u00ed. BioMed Research International, 2014<\/em>, 151479.<\/span><\/li>\n
  • Wang, X., Liu, B., Xu, Q., Sun, H., Shi, M., & Zhang, L. (2017). GHK-Cu-liposomy urychluj\u00ed hojen\u00ed opa\u0159en\u00fdch ran u my\u0161\u00ed podporou proliferace bun\u011bk a angiogeneze. Regenerace a hojen\u00ed ran, 25<\/em>(2), 280\u2013287.<\/span><\/li>\n
  • Zhou, M., Wu, X., Luo, J., Yang, G., Lu, Y., Lin, S., & Li, Y. (2021). Skafoidy na b\u00e1zi hedv\u00e1b\u00ed ti\u0161t\u011bn\u00e9 ve 3D, do kter\u00fdch jsou za\u010dlen\u011bny m\u011bd\u011bn\u00e9 peptidy, podporuj\u00ed vaskularizovanou regeneraci kost\u00ed. Chemick\u00fd in\u017een\u00fdrsk\u00fd \u010dasopis, 417<\/em>, 129327.<\/span><\/li>\n
  • Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Zlep\u0161en\u00ed hojen\u00ed v\u0159ed\u016f u pacient\u016f s diabetem pomoc\u00ed topick\u00e9 l\u00e9\u010dby m\u011bd\u00ed glycyl-L-histidyl-L-lysinem. Oprava a regenerace ran, 2<\/em>(4), 259\u2013269.<\/span><\/li>\n
  • Li, H., Low, Y. S. J., Chong, H. P., Zin, M. T., Lee, C. Y., & Li, B. (2015). Dod\u00e1v\u00e1n\u00ed m\u011bd\u011bn\u00fdch peptid\u016f k\u016f\u017e\u00ed pomoc\u00ed mikropilul: V\u00fdzvy a strategie pro dod\u00e1v\u00e1n\u00ed do dermis. Journal of Pharmaceutical Investigation, 45<\/em>(6), 633\u2013642.<\/span><\/li>\n
  • Pickart, L., & Margolina, A. (2018). Regenerativn\u00ed a ochrann\u00e9 \u00fa\u010dinky peptidu GHK-Cu ve sv\u011btle nov\u00fdch genov\u00fdch dat. International Journal of Molecular Sciences, 19<\/em>(7), 1987.<\/span><\/li>\n
  • Badenhorst, T., Svirskis, D., Merrilees, M., & Bolke, L. (2016). \u00da\u010dinky GHK-Cu na expresi MMP a TIMP, produkci kolagenu a elastinu a parametry mimick\u00fdch vr\u00e1sek. Journal of Aging Science, 4<\/em>(2), 1\u20138.<\/span><\/li>\n
  • Reddy, B. Y., Jow, T., & Hantash, B. M. (2012). Bioaktivn\u00ed oligopeptidy v dermatologii: \u010c\u00e1st I. Experiment\u00e1ln\u00ed dermatologie, 21<\/em>(8), 563\u2013568.<\/span><\/li>\n
  • Hostynek, J. J., Dreher, F., & Maibach, H. I. (2010). Lidsk\u00e9 zadr\u017een\u00ed a penetrace m\u011bd\u011bn\u00e9ho tripeptidu v k\u016f\u017ei in vitro v z\u00e1vislosti na vrstv\u011b k\u016f\u017ee. V\u00fdzkum z\u00e1n\u011btu, 59<\/em>(12), 1051\u20131059.<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    D\u00e1vky m\u011b\u010fnat\u00e9ho peptidu (GHK-Cu) v pokusech na zv\u00ed\u0159atech a u lid\u00ed D\u00e1vky m\u011b\u010fnat\u00e9ho peptidu pou\u017e\u00edvan\u00e9 ve v\u011bdeck\u00e9m v\u00fdzkumu se v\u00fdrazn\u011b li\u0161\u00ed v z\u00e1vislosti na v\u00fdzkumn\u00e9m modelu\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[93],"tags":[],"class_list":["post-46052","post","type-post","status-publish","format-standard","hentry","category-kategoria-ghk-cu","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts\/46052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/comments?post=46052"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts\/46052\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/media?parent=46052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/categories?post=46052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/tags?post=46052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}