V\u011bdeck\u00fd z\u00e1jem o Pinealon vzrostl kv\u016fli jeho potenci\u00e1ln\u00edm neuroprotektivn\u00edm vlastnostem v experiment\u00e1ln\u00edch modelech Alzheimerovy choroby. A\u010dkoli zat\u00edm nebyly provedeny rozs\u00e1hl\u00e9 klinick\u00e9 studie u lid\u00ed hodnoc\u00edc\u00ed Pinealon jako l\u00e9\u010dbu Alzheimerovy choroby, n\u011bkolik preklinick\u00fdch studi\u00ed analyzovalo jeho dopad na p\u0159e\u017eit\u00ed neuron\u016f, integritu synaps a procesy spojen\u00e9 s neurodegenerac\u00ed (1,2).<\/p>\n
Jedna z nejv\u00fdznamn\u011bj\u0161\u00edch studi\u00ed byla provedena Kraskovskou a spolupracovn\u00edky s vyu\u017eit\u00edm in vitro modelu amyloidem indukovan\u00e9 synaptotoxicity, kter\u00fd odr\u00e1\u017e\u00ed n\u011bkter\u00e9 aspekty po\u0161kozen\u00ed neuron\u016f pozorovan\u00e9 u Alzheimerovy choroby (1). V t\u00e9to studii byly prim\u00e1rn\u00ed neurony my\u0161\u00edho hipokampu vystaveny amyloidn\u00ed toxicit\u011b, kter\u00e1 obvykle vede ke sn\u00ed\u017een\u00ed po\u010dtu zral\u00fdch dendritick\u00fdch v\u00fdb\u011b\u017ek\u016f pod\u00edlej\u00edc\u00edch se na neuron\u00e1ln\u00ed komunikaci. L\u00e9\u010dba peptidem EDR (Pinealon) v koncentraci 200 ng\/ml zv\u00fd\u0161ila po\u010det houbovit\u00fdch dendritick\u00fdch v\u00fdb\u011b\u017ek\u016f o 71% a obnovila jejich po\u010det na norm\u00e1ln\u00ed hodnoty (1).<\/p>\n
H\u0159ibovit\u00e9 v\u00fdb\u011b\u017eky dendrit\u016f jsou vysoce stabiln\u00ed synaptick\u00e9 struktury, kter\u00e9 hraj\u00ed kl\u00ed\u010dovou roli v u\u010den\u00ed, formov\u00e1n\u00ed pam\u011bti a dlouhodob\u00e9m uchov\u00e1v\u00e1n\u00ed informac\u00ed. Ztr\u00e1ta t\u011bchto struktur je \u010dasto spojov\u00e1na s kognitivn\u00edm poklesem a neurodegenerativn\u00edmi onemocn\u011bn\u00edmi. Schopnost Pinealonu obnovovat hustotu dendritick\u00fdch v\u00fdb\u011b\u017ek\u016f nazna\u010duje, \u017ee m\u016f\u017ee pomoci zachovat neuron\u00e1ln\u00ed spojen\u00ed a podporovat neuroplasticitu v podm\u00ednk\u00e1ch neurodegenerativn\u00edho stresu (1).<\/p>\n
Dodatkowych dowod\u00f3w dostarczy\u0142y badania Khavinsona a jeho spolupracovn\u00edk\u016f, kte\u0159\u00ed hodnotili kr\u00e1tk\u00e9 bioregula\u010dn\u00ed peptidy na my\u0161\u00edm modelu Alzheimerovy choroby (2). V\u00fdsledky prok\u00e1zaly neuroprotektivn\u00ed \u00fa\u010dinky spojen\u00e9 se zv\u00fd\u0161enou odolnost\u00ed neuron\u016f a ochranou p\u0159ed v\u011bkem souvisej\u00edc\u00edmi neurodegenerativn\u00edmi zm\u011bnami. Pinealon byl za\u0159azen do skupiny epigenetick\u00fdch peptid\u016f schopn\u00fdch regulovat bun\u011b\u010dnou aktivitu a podporovat p\u0159e\u017eit\u00ed neuron\u016f v experiment\u00e1ln\u00edch podm\u00ednk\u00e1ch (2).<\/p>\n
Za pozorovan\u00e9 \u00fa\u010dinky m\u016f\u017ee odpov\u00eddat n\u011bkolik biologick\u00fdch mechanism\u016f. Laboratorn\u00ed studie nazna\u010duj\u00ed, \u017ee Pinealon m\u016f\u017ee sni\u017eovat oxida\u010dn\u00ed stres, omezovat po\u0161kozen\u00ed bun\u011bk, ovliv\u0148ovat expresi gen\u016f a podporovat \u017eivotnost neuron\u016f (2\u20134). Tyto \u00fa\u010dinky dohromady mohou pom\u00e1hat zachovat synaptick\u00e9 struktury a omezovat n\u011bkter\u00e9 stresov\u00e9 faktory spojen\u00e9 s neurodegenerac\u00ed.<\/p>\n
P\u0159esto\u017ee jsou tyto v\u00fdsledky slibn\u00e9, sou\u010dasn\u00e9 d\u016fkazy poch\u00e1zej\u00ed p\u0159ev\u00e1\u017en\u011b z bun\u011b\u010dn\u00fdch a \u017eivo\u010di\u0161n\u00fdch studi\u00ed. Dosud nebyly publikov\u00e1ny \u017e\u00e1dn\u00e9 velk\u00e9 klinick\u00e9 studie hodnot\u00edc\u00ed Pinealon u Alzheimerovy choroby. Pinealon by proto m\u011bl b\u00fdt v sou\u010dasn\u00e9 dob\u011b pova\u017eov\u00e1n za experiment\u00e1ln\u00ed neuroprotektivn\u00ed peptid vy\u017eaduj\u00edc\u00ed dal\u0161\u00ed v\u00fdzkum, nikoli za zavedenou l\u00e9\u010dbu Alzheimerovy choroby.<\/p>\n
V rusk\u00e9 literatu\u0159e o bioregula\u010dn\u00edch peptidech je Pinealon \u010dasto klasifikov\u00e1n jako geroprotektivum. Tento term\u00edn ozna\u010duje slou\u010deniny, kter\u00e9 mohou podporovat zdrav\u00e9 st\u00e1rnut\u00ed, zachov\u00e1n\u00ed fyziologick\u00fdch funkc\u00ed a potenci\u00e1ln\u011b zpomalovat n\u011bkter\u00e9 aspekty biologick\u00e9ho st\u00e1rnut\u00ed. Zna\u010dn\u00e1 \u010d\u00e1st t\u011bchto v\u00fdzkum\u016f poch\u00e1z\u00ed z prac\u00ed Vladimira Khavinsona a jeho spolupracovn\u00edk\u016f, kte\u0159\u00ed rozs\u00e1hle analyzovali kr\u00e1tk\u00e9 regula\u010dn\u00ed peptidy z hlediska jejich potenci\u00e1ln\u00ed role v dlouhov\u011bkosti a udr\u017een\u00ed zdrav\u00ed ve st\u00e1\u0159\u00ed (5).<\/p>\n
Jedna z nejrelevantn\u011bj\u0161\u00edch studi\u00ed t\u00fdkaj\u00edc\u00edch se Pinealonu a zdrav\u00e9ho st\u00e1rnut\u00ed byla provedena Meshchaninovou a spolupracovn\u00edky u jedinc\u016f ve v\u011bku 41 a\u017e 83 let s chronickou polymorbiditou a organick\u00fdm mozkov\u00fdm syndromem v remisi (5). V\u00fdzkumn\u00edci hodnotili vliv Pinealonu a dal\u0161\u00edho peptidov\u00e9ho bioregul\u00e1toru, Vesugenu, na biomarkery souvisej\u00edc\u00ed s biologick\u00fdm v\u011bkem a funk\u010dn\u00edm stavem organismu.<\/p>\n
V\u011bdci zaznamenali, \u017ee Pinealon vyvolal v\u00fdznamn\u00e9 anabolick\u00e9 \u00fa\u010dinky a zlep\u0161il funk\u010dn\u00ed aktivitu centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu a dal\u0161\u00edch d\u016fle\u017eit\u00fdch org\u00e1n\u016f (5). Tyto zm\u011bny byly spojeny se zpomalen\u00fdm tempem biologick\u00e9ho st\u00e1rnut\u00ed posuzovan\u00fdm na z\u00e1klad\u011b analyzovan\u00fdch biomarker\u016f. Auto\u0159i dosp\u011bli k z\u00e1v\u011bru, \u017ee Pinealon vykazuje jak geroprotektivn\u00ed, tak neuroprotektivn\u00ed vlastnosti, kter\u00e9 mohou podporovat zdrav\u00e9 st\u00e1rnut\u00ed u jedinc\u016f s funk\u010dn\u00edmi poruchami souvisej\u00edc\u00edmi s v\u011bkem.<\/p>\n
Studie tak\u00e9 nazna\u010dovaly, \u017ee Pinealon m\u016f\u017ee ovliv\u0148ovat metabolick\u00e9 a bun\u011b\u010dn\u00e9 dr\u00e1hy zapojen\u00e9 do procesu st\u00e1rnut\u00ed. A\u010dkoli bylo b\u011bhem l\u00e9\u010dby pozorov\u00e1no zlep\u0161en\u00ed n\u011bkolika biomarker\u016f st\u00e1rnut\u00ed, peptid nem\u011bl vliv na kondenzaci chromatinu, co\u017e nazna\u010dovalo absenci detekovateln\u00fdch nep\u0159\u00edzniv\u00fdch \u00fa\u010dink\u016f na stabilitu genetick\u00e9ho materi\u00e1lu v experiment\u00e1ln\u00edch podm\u00ednk\u00e1ch (5). V\u00fdzkumn\u00edci to pova\u017eovali za v\u00fdznamn\u00fd bezpe\u010dnostn\u00ed ukazatel a doporu\u010dili dal\u0161\u00ed studie.<\/p>\n
N\u011bkolik laboratorn\u00edch studi\u00ed poskytuje potenci\u00e1ln\u00ed mechanistick\u00e1 vysv\u011btlen\u00ed t\u011bchto pozorov\u00e1n\u00ed. Bylo prok\u00e1z\u00e1no, \u017ee Pinealon sni\u017euje oxida\u010dn\u00ed stres, podporuje p\u0159e\u017eit\u00ed neuron\u016f, reguluje dr\u00e1hy souvisej\u00edc\u00ed se serotoninem a ovliv\u0148uje genovou expresi prost\u0159ednictv\u00edm epigenetick\u00fdch mechanism\u016f (2\u20134, 6). Jeliko\u017e oxida\u010dn\u00ed stres a naru\u0161en\u00e1 bun\u011b\u010dn\u00e1 regulace jsou pova\u017eov\u00e1ny za p\u0159isp\u00edvaj\u00edc\u00ed faktory k biologick\u00e9mu st\u00e1rnut\u00ed, tyto \u00fa\u010dinky mohou \u010d\u00e1ste\u010dn\u011b vysv\u011btlovat pozorovan\u00e9 geroprotektivn\u00ed vlastnosti Pinealonu.<\/p>\n
I p\u0159es slibn\u00e9 v\u00fdsledky z\u016fst\u00e1v\u00e1 v\u00fdzkum Pinealonu a proces\u016f st\u00e1rnut\u00ed relativn\u011b omezen\u00fd ve srovn\u00e1n\u00ed s podrobn\u011bji prozkouman\u00fdmi intervencemi souvisej\u00edc\u00edmi s dlouhov\u011bkost\u00ed. Jsou zapot\u0159eb\u00ed dal\u0161\u00ed klinick\u00e9 studie, kter\u00e9 by ur\u010dily, zda se zlep\u0161en\u00ed biomarker\u016f biologick\u00e9ho v\u011bku prom\u00edtne do v\u00fdznamn\u00fdch dlouhodob\u00fdch p\u0159\u00ednos\u016f pro zdrav\u00ed. P\u0159esto dostupn\u00e9 \u00fadaje \u0159ad\u00ed Pinealon mezi l\u00e9pe prozkouman\u00e9 bioregula\u010dn\u00ed peptidy v oblasti zdrav\u00e9ho st\u00e1rnut\u00ed a neurogerontologie.<\/p>\n
Sen jest jednym z najcz\u0119\u015bciej poruszanych temat\u00f3w w\u015br\u00f3d os\u00f3b zainteresowanych Pinealonem. Z\u00e1jem o hesla jako \u201ePinealon a sen\u201d, \u201ePinealon na sen\u201d, \u201ePinealon peptide sleep\u201d, \u201ePinealon REM sleep\u201d a \u201ePinealon circadian rhythm\u201d v posledn\u00edch letech v\u00fdrazn\u011b vzrostl. P\u0159i hodnocen\u00ed t\u011bchto tvrzen\u00ed je v\u0161ak d\u016fle\u017eit\u00e9 rozli\u0161ovat mezi v\u011bdeck\u00fdmi d\u016fkazy a anekdotick\u00fdmi pozorov\u00e1n\u00edmi.<\/p>\n
V sou\u010dasn\u00e9 dob\u011b \u017e\u00e1dn\u00e1 kontrolovan\u00e1 klinick\u00e1 studie neprok\u00e1zala, \u017ee by Pinealon zlep\u0161il kvalitu sp\u00e1nku, zv\u00fd\u0161il pod\u00edl REM sp\u00e1nku, reguloval cirkadi\u00e1nn\u00ed rytmus nebo l\u00e9\u010dil poruchy sp\u00e1nku. Dostupn\u00e1 v\u011bdeck\u00e1 literatura se prim\u00e1rn\u011b zam\u011b\u0159uje na neuroprotekci, regulaci oxida\u010dn\u00edho stresu, kognitivn\u00ed funkce, expresi serotoninu a zdrav\u00e9 st\u00e1rnut\u00ed, nikoli na v\u00fdsledky souvisej\u00edc\u00ed se sp\u00e1nkem (2\u20136).<\/p>\n
Jedn\u00edm z mo\u017en\u00fdch vysv\u011btlen\u00ed z\u00e1jmu o Pinealon a sp\u00e1nek jsou studie ukazuj\u00edc\u00ed, \u017ee peptid stimuluje expresi genu k\u00f3duj\u00edc\u00edho hydroxydu tryptofanu \u2013 enzym omezuj\u00edc\u00ed rychlost synt\u00e9zy serotoninu (6). Serotonin je prekurzorem melatoninu a hraje z\u00e1sadn\u00ed roli v regulaci cyklu sp\u00e1nku a bd\u011blosti, n\u00e1lady a neurologick\u00fdch funkc\u00ed. V\u00fdzkumn\u00edci nazna\u010duj\u00ed, \u017ee schopnost Pinealon ovliv\u0148ovat dr\u00e1hy souvisej\u00edc\u00ed se serotoninem m\u016f\u017ee p\u0159isp\u00edvat k jeho neuroprotektivn\u00ed a geroprotektivn\u00ed aktivit\u011b (6).<\/p>\n
Jeliko\u017e je serotonin \u00fazce spojen s regulac\u00ed sp\u00e1nku, n\u011bkte\u0159\u00ed v\u00fdzkumn\u00edci vyslovili hypot\u00e9zu, \u017ee Pinealon by mohl nep\u0159\u00edmo ovliv\u0148ovat procesy souvisej\u00edc\u00ed se sp\u00e1nkem. V sou\u010dasn\u00e9 dob\u011b v\u0161ak chyb\u00ed p\u0159\u00edm\u00e9 klinick\u00e9 d\u016fkazy podporuj\u00edc\u00ed zlep\u0161en\u00ed kvality sp\u00e1nku, d\u00e9lky sp\u00e1nku, REM f\u00e1ze nebo regulace cirkadi\u00e1nn\u00edho rytmu.<\/p>\n
Zpr\u00e1vy komunity a online diskuse poskytuj\u00ed dal\u0161\u00ed informace vysv\u011btluj\u00edc\u00ed z\u00e1jem spole\u010dnosti Pinealon o tuto oblast. V anekdotick\u00fdch popisech n\u011bkte\u0159\u00ed jedinci hl\u00e1s\u00ed subjektivn\u00ed zlep\u0161en\u00ed kvality sp\u00e1nku, lep\u0161\u00ed vybavov\u00e1n\u00ed sn\u016f, intenzivn\u011bj\u0161\u00ed sn\u011bn\u00ed a v\u011bt\u0161\u00ed pocit odpo\u010dinku po probuzen\u00ed. Jin\u00ed uv\u00e1d\u011bj\u00ed, \u017ee u\u017e\u00edvaj\u00ed donosov\u00fd Pinealon p\u0159ed span\u00edm, proto\u017ee poci\u0165uj\u00ed p\u0159\u00ednosy souvisej\u00edc\u00ed sp\u00e1nkem a sn\u011bn\u00edm.<\/p>\n
Je t\u0159eba zd\u016fraznit, \u017ee tato pozorov\u00e1n\u00ed jsou anekdotick\u00e1 a nebyla potvrzena v kontrolovan\u00fdch klinick\u00fdch studi\u00edch. Zku\u0161enosti u\u017eivatel\u016f mohou b\u00fdt ovlivn\u011bny mnoha faktory, v\u010detn\u011b o\u010dek\u00e1v\u00e1n\u00ed, pou\u017eit\u00fdch d\u00e1vkovac\u00edch protokol\u016f, individu\u00e1ln\u00ed neurochemie, sou\u010dasn\u011b u\u017e\u00edvan\u00fdch dopl\u0148k\u016f a placebo efektu.<\/p>\n
Vzhledem k omezen\u00e9mu mno\u017estv\u00ed klinick\u00fdch \u00fadaj\u016f nelze v sou\u010dasn\u00e9 dob\u011b formulovat doporu\u010den\u00ed zalo\u017een\u00e1 na d\u016fkazech pro optim\u00e1ln\u00ed na\u010dasov\u00e1n\u00ed u\u017e\u00edv\u00e1n\u00ed Pinealonu pro ovlivn\u011bn\u00ed sp\u00e1nku. Budouc\u00ed studie se zam\u011b\u0159en\u00edm na kvalitu sp\u00e1nku, REM f\u00e1zi, cirkadi\u00e1nn\u00ed biologii a regulaci neurotransmiter\u016f mohou pomoci objasnit, zda Pinealon v\u00fdznamn\u011b ovliv\u0148uje parametry souvisej\u00edc\u00ed se sp\u00e1nkem.<\/p>\n
Obecn\u00e9 v\u011bdeck\u00e9 d\u016fkazy podporuj\u00ed roli pinealonu v neuron\u00e1ln\u00ed regulaci a drah\u00e1ch souvisej\u00edc\u00edch se serotoninem, zat\u00edmco tvrzen\u00ed o p\u0159\u00ednosech pro sp\u00e1nek z\u016fst\u00e1vaj\u00ed p\u0159edb\u011b\u017en\u00e1 a zakl\u00e1daj\u00ed se sp\u00ed\u0161e na anekdotick\u00fdch pozorov\u00e1n\u00edch ne\u017e na zaveden\u00fdch klinick\u00fdch d\u016fkazech.<\/p>\n
Obsah je ur\u010den pouze pro vzd\u011bl\u00e1vac\u00ed a informa\u010dn\u00ed \u00fa\u010dely a nem\u011bl by b\u00fdt vykl\u00e1d\u00e1n jako l\u00e9ka\u0159sk\u00e1 rada, diagn\u00f3za, l\u00e9\u010dba nebo odborn\u00e9 doporu\u010den\u00ed. Pinealon nebyl schv\u00e1len americk\u00fdm \u00da\u0159adem pro kontrolu potravin a l\u00e9\u010div (FDA), Evropskou l\u00e9kovou agenturou (EMA) ani v\u011bt\u0161inou jin\u00fdch regula\u010dn\u00edch org\u00e1n\u016f pro l\u00e9\u010dbu Alzheimerovy choroby, poruch sp\u00e1nku, onemocn\u011bn\u00ed souvisej\u00edc\u00edch se st\u00e1rnut\u00edm nebo jak\u00fdchkoliv jin\u00fdch l\u00e9ka\u0159sk\u00fdch indikac\u00ed. V\u011bt\u0161ina dostupn\u00fdch \u00fadaj\u016f poch\u00e1z\u00ed z p\u0159edklinick\u00fdch studi\u00ed, studi\u00ed na zv\u00ed\u0159atech a omezen\u00e9ho po\u010dtu studi\u00ed na lidech. Jsou zapot\u0159eb\u00ed dal\u0161\u00ed, dob\u0159e navr\u017een\u00e9 klinick\u00e9 studie k lep\u0161\u00edmu ur\u010den\u00ed \u00fa\u010dinnosti, bezpe\u010dnosti a dlouhodob\u00e9ho \u00fa\u010dinku Pinealonu u r\u016fzn\u00fdch populac\u00ed.<\/p>\n
(1)<\/strong> Kraskovskaya, N. A., Kukanova, E. O., Lin\u2019kova, N. S., Popugaeva, E. A., & Khavinson, V. K. (2017). Tripeptidy obnovuj\u00ed po\u010det neuron\u00e1ln\u00edch trn\u016f v podm\u00ednk\u00e1ch in vitro modelovan\u00e9ho Alzheimerova onemocn\u011bn\u00ed<\/em>. Bulletin experiment\u00e1ln\u00ed biologie a medic\u00edny, 163<\/em>(4), 547\u2013550. https:\/\/doi.org\/10.1007\/s10517-017-3847-2<\/a><\/span> (2)<\/strong> Khavinson, V., Ilina, A., Kraskovskaya, N., Linkova, N., Kolchina, N., Mironova, E., Erofeev, A., & Petukhov, M. (2021). Neuroprotektivn\u00ed \u00fa\u010dinky tripeptid\u016f \u2013 epigenetick\u00fdch regul\u00e1tor\u016f na my\u0161\u00edm modelu Alzheimerovy choroby<\/em>. Farmacie, 14<\/em>(6), 515. https:\/\/doi.org\/10.3390\/ph14060515<\/a><\/span> (3)<\/strong> Khavinson, V., Ribakova, Y., Trofimova, S., et al. (2011). Pinealon zvy\u0161uje \u017eivotaschopnost bun\u011bk potla\u010den\u00edm hladiny voln\u00fdch radik\u00e1l\u016f a aktivac\u00ed prolifera\u010dn\u00edch proces\u016f<\/em>. Rejuvenation Research, 14<\/em>(5), 517\u2013523. https:\/\/doi.org\/10.1089\/rej.2011.1172<\/a><\/span> (4)<\/strong> Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K., & Vanyushin, B. F. (2011). Penetrace kr\u00e1tk\u00fdch fluorescen\u010dn\u011b zna\u010den\u00fdch peptid\u016f do j\u00e1dra v bu\u0148k\u00e1ch HeLa a in vitro specifick\u00e1 interakce peptid\u016f s deoxyribooligonucleotidy a DNA<\/em>. Biochemie (Moskva), 76<\/em>(11), 1210\u20131219. https:\/\/doi.org\/10.1134\/S0006297911110022<\/a><\/span> (5)<\/strong> Meshchaninov, V. N., Tkachenko, E. L., Zharkov, S. V., Gavrilov, I. V., & Katyreva, Y. E. (2015). Vliv syntetick\u00fdch peptid\u016f na st\u00e1rnut\u00ed pacient\u016f s chronickou polymorbiditou a syndromem organick\u00e9ho po\u0161kozen\u00ed centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu v remisi<\/em>. Pokroky v gerontologii, 28<\/em>(1), 62\u201367.<\/span> (6)<\/strong> Khavinson, V. K., Lin\u2019kova, N. S., Tarnovskaya, S. I., Umnov, R. S., Elashkina, E. V., & Durnova, A. O. (2014). Kr\u00e1tk\u00e9 peptidy stimuluj\u00ed expresi serotoninu v bu\u0148k\u00e1ch mozkov\u00e9 k\u016fry<\/em>. Bulletin experiment\u00e1ln\u00ed biologie a medic\u00edny, 157<\/em>(1), 77\u201380. https:\/\/doi.org\/10.1007\/s10517-014-2496-y<\/a><\/span> V\u00fdzkum pinealonu a Alzheimerovy choroby V\u011bdeck\u00fd z\u00e1jem o pinealon vzrostl kv\u016fli jeho potenci\u00e1ln\u00edm neuroprotektivn\u00edm vlastnostem v experiment\u00e1ln\u00edch modelech Alzheimerovy choroby. A\u010dkoli dosud nebyly provedeny\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[253],"tags":[],"class_list":["post-51175","post","type-post","status-publish","format-standard","hentry","category-kategoria-pinealon","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts\/51175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/comments?post=51175"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/posts\/51175\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/media?parent=51175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/categories?post=51175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/cs\/wp-json\/wp\/v2\/tags?post=51175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/28853087\/<\/a><\/span><\/p>\n
Odkaz na den\u00edk: https:\/\/www.mdpi.com\/1424-8247\/14\/6\/515<\/a><\/span><\/p>\n
Odkaz na den\u00edk: https:\/\/journals.sagepub.com\/doi\/abs\/10.1089\/rej.2011.1172<\/a><\/span><\/p>\n
Odkaz na den\u00edk: https:\/\/link.springer.com\/article\/10.1134\/S0006297911110022<\/a><\/span><\/p>\n
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/26390612\/<\/a><\/span><\/p>\n
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/24909721\/<\/a><\/span><\/p>","protected":false},"excerpt":{"rendered":"