{"id":46048,"date":"2026-04-20T16:40:30","date_gmt":"2026-04-20T14:40:30","guid":{"rendered":"https:\/\/semaxpolska.com\/?p=46048"},"modified":"2026-04-16T16:52:22","modified_gmt":"2026-04-16T14:52:22","slug":"%e9%8a%85%e3%83%9a%e3%83%97%e3%83%81%e3%83%89ghk-cu%e3%82%92%e7%ad%8b%e8%82%89%e5%86%8d%e7%94%9f%e3%81%a8%e7%b5%84%e7%b9%94%e4%bf%ae%e5%be%a9%e3%81%ae%e8%a6%b3%e7%82%b9%e3%81%8b%e3%82%89%e5%88%86","status":"publish","type":"post","link":"https:\/\/bioevidencehub.com\/ja\/jakie-badania-analizowaly-peptyd-miedziowy-ghk-cu-w-kontekscie-regeneracji-miesni-i-naprawy-tkanek\/","title":{"rendered":"\u9285\u30da\u30d7\u30c1\u30c9(GHK-Cu)\u3092\u7b4b\u8089\u518d\u751f\u3084\u7d44\u7e54\u4fee\u5fa9\u306e\u89b3\u70b9\u304b\u3089\u5206\u6790\u3057\u305f\u7814\u7a76\u306f\u3042\u308a\u307e\u3059\u304b\uff1f"},"content":{"rendered":"<p data-start=\"98\" data-end=\"1800\">\u9285\u30da\u30d7\u30c1\u30c9\u306f\u3001\u7d44\u7e54\u4fee\u5fa9\u306b\u95a2\u9023\u3059\u308b\u591a\u304f\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u3068\u5c11\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u7814\u7a76\u3055\u308c\u3066\u304d\u305f\u3002\u5229\u7528\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u306e\u307b\u3068\u3093\u3069\u306f\u3001\u5275\u50b7\u6cbb\u7652\u3001\u7d50\u5408\u7d44\u7e54\u518d\u751f\u3001\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\u30fb\u30d9\u30fc\u30b9\u306e\u4fee\u5fa9\u30e2\u30c7\u30eb\u306e\u7814\u7a76\u306b\u3088\u308b\u3082\u306e\u3067\u3001 \u7b4b\u8089\u518d\u751f\u3060\u3051\u306b\u76f4\u63a5\u7126\u70b9\u3092\u3042\u3066\u305f\u7814\u7a76\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u9285\u30da\u30d7\u30c1\u30c9\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u3092\u523a\u6fc0\u3057\u3001\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\uff08\u7d44\u7e54\u306e\u69cb\u9020\u3068\u6c34\u5206\u88dc\u7d66\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u5206\u5b50\uff09\u306e\u30ec\u30d9\u30eb\u3092\u4e0a\u3052\u3001 \u7d44\u7e54\u4fee\u5fa9\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u7d30\u80de\u3067\u3042\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u3001\u7814\u7a76\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u640d\u50b7\u3057\u305f\u69cb\u9020\u7269\u306e\u56de\u5fa9\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u9593\u63a5\u7684\u306b\u7b4b\u8089\u306e\u518d\u751f\u306b\u3082\u95a2\u4fc2\u3059\u308b(Pickart, 2008; Sim\u00e9on et al., 1999)\u3002.<\/p>\n<p data-start=\"98\" data-end=\"1800\">\u5b9f\u9a13\u5ba4(in vitro)\u3067\u3082\u52d5\u7269(in vivo)\u3067\u3082\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u95a2\u4fc2\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u65b0\u3057\u3044\u8840\u7ba1\u306e\u5f62\u6210\u3067\u3042\u308b\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u3057\u3001\u3088\u308a\u3088\u3044\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u653e\u5c04\u7dda\u50b7\u5bb3\u3092\u542b\u3080\u52d5\u7269\u306e\u5275\u50b7\u30e2\u30c7\u30eb\u3067\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u3092\u5c40\u6240\u7684\u306b\u5857\u5e03\u3059\u308b\u3053\u3068\u3067\u6cbb\u7652\u306e\u8cea\u304c\u5411\u4e0a\u3057\u3001\u5275\u50b7\u306e\u9589\u9396\u304c\u65e9\u307e\u308a\u307e\u3057\u305f(Parker et al., 2013)\u3002\u81e8\u5e8a\u30c7\u30fc\u30bf\u3068\u3057\u3066\u306f\u7cd6\u5c3f\u75c5\u6027\u6f70\u760d\u306e\u7814\u7a76\u304c\u3042\u308a\u3001\u305d\u3053\u3067\u306f\u9285\u30da\u30d7\u30c1\u30c9\u306f\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u3088\u308a\u6cbb\u7652\u7387\u3092\u5411\u4e0a\u3055\u305b\u307e\u3057\u305f(Mulder et al., 1994)\u3002\u3055\u3089\u306b\u9285\u30da\u30d7\u30c1\u30c9\u3092\u4f7f\u3063\u305f\u751f\u4f53\u6750\u6599\u3084\u7d44\u7e54\u306e\u8db3\u5834\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u306f\u3001\u8840\u7ba1\u306e\u5f62\u6210\u304c\u6539\u5584\u3055\u308c\u3001\u7d44\u7e54\u306e\u7d71\u5408\u304c\u3088\u304f\u306a \u3063\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u518d\u751f\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u9285\u30da\u30d7\u30c1\u30c9\u306e\u5f79\u5272\u3092\u3055\u3089\u306b\u88cf\u3065\u3051\u3066\u3044\u307e\u3059(Zhou et al., 2021; Molavi et al., 2020)\u3002.<\/p>\n<p data-start=\"1802\" data-end=\"2665\">\u4f5c\u7528\u6a5f\u5e8f\u304b\u3089\u898b\u308b\u3068\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u9285\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u30fb\u30da\u30d7\u30c1\u30c9\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u4fee\u5fa9\u904e\u7a0b\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3059\u308b\u306e\u3092\u52a9\u3051\u307e\u3059\u3002\u6210\u9577\u56e0\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30fb\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u547c\u3070\u308c\u308b\u9175\u7d20\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u4f5c\u7528\u304c\u76f8\u307e\u3063\u3066\u3001\u7d44\u7e54\u69cb\u9020\u306e\u518d\u69cb\u7bc9\u304c\u4fc3\u9032\u3055\u308c\u3001\u3053\u308c\u306f\u640d\u50b7\u5f8c\u306e\u7b4b\u8089\u56de\u5fa9\u306e\u91cd\u8981\u306a\u90e8\u5206\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7b4b\u8089\u306e\u518d\u751f\u3084\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u30d2\u30c8\u3067\u306e\u76f4\u63a5\u7684\u306a\u7814\u7a76\u306f\u3001\u307e\u3060\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u7559\u610f\u3059\u3079\u304d\u3067\u3042\u308b\u3002\u5275\u50b7\u6cbb\u7652\u3084\u7d50\u5408\u7d44\u7e54\u306b\u95a2\u3059\u308b\u7814\u7a76\u7d50\u679c\u306f\u3001\u9069\u5207\u306a\u81e8\u5e8a\u8a66\u9a13\u304c\u884c\u308f\u308c\u306a\u3044\u9650\u308a\u3001\u30d2\u30c8\u306e\u7b4b\u8089\u518d\u751f\u306b\u76f4\u63a5\u5fdc\u7528\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3053\u3068\u306f\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002.<\/p>\n<h2 data-start=\"2672\" data-end=\"2759\"><strong data-start=\"2672\" data-end=\"2759\">\u9285\u30da\u30d7\u30c1\u30c9\u306f\u5916\u50b7\u3084\u624b\u8853\u5f8c\u306e\u30e2\u30c7\u30eb\u3067\u30c6\u30b9\u30c8\u3055\u308c\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/h2>\n<p data-start=\"2761\" data-end=\"3825\">\u9285\u30da\u30d7\u30c1\u30c9\u306f\u591a\u304f\u306e\u5916\u50b7\u95a2\u9023\u7814\u7a76\u30e2\u30c7\u30eb\u3001\u7279\u306b\u5275\u50b7\u6cbb\u7652\u3001\u653e\u5c04\u7dda\u969c\u5bb3\u3001\u708e\u75c7\u306e\u6587\u8108\u3067\u5206\u6790\u3055\u308c\u3066\u304d\u305f\u3002\u3053\u308c\u3089\u306e\u30e2\u30c7\u30eb\u306f\u5916\u79d1\u624b\u8853\u306e\u3042\u3068\u306e\u518d\u751f\u72b6\u614b\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u95a2\u9023\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u6025\u6027\u5275\u50b7\u3084\u706b\u50b7\u306e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u518d\u4e0a\u76ae\u5316\u3001\u3059\u306a\u308f\u3061\u76ae\u819a\u8868\u9762\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u6c88\u7740\u3092\u5897\u3084\u3057\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u3057\u3001\u7d44\u7e54\u640d\u50b7\u5f8c\u306e\u6cbb\u7652\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059(Wang et al., 2017)\u3002.<\/p>\n<p data-start=\"2761\" data-end=\"3825\">\u653e\u5c04\u7dda\u640d\u50b7\u30e2\u30c7\u30eb\u3067\u306f\u3001\u6cbb\u7652\u6210\u7e3e\u3068\u7d44\u7e54\u5f37\u5ea6\u304c\u6539\u5584\u3055\u308c\u3001\u56de\u5fa9\u304c\u9045\u308c\u308b\u72b6\u6cc1\u3067\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u305f\uff08Parker\u3089\u30012013\u5e74\uff09\u3002\u80ba\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u305d\u306e\u4ed6\u306e\u7814\u7a76\u3067\u306f\u3001\u5316\u5b66\u7684\u640d\u50b7\u5f8c\u306e\u7dda\u7dad\u5316\u306e\u6291\u5236\u3068\u7d44\u7e54\u4fee\u5fa9\u306e\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u308b\uff08Ma\u3089\u30012020\uff1bBian\u3089\u30012024\uff09\u3002\u6025\u6027\u80ba\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082\u3001\u708e\u75c7\u306e\u8efd\u6e1b\u3068\u7d44\u7e54\u69cb\u9020\u306e\u6539\u5584\u304c\u89b3\u5bdf\u3055\u308c\u305f\uff08Park\u3089\u30012016\u5e74\uff09\u3002.<\/p>\n<p data-start=\"3827\" data-end=\"4496\">\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u304c\u50b7\u5bb3\u5f8c\u306e\u74b0\u5883\u3067\u7d44\u7e54\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u3001\u6210\u9577\u56e0\u5b50\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u5897\u52a0\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u8abf\u7bc0\u306a\u3069\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u624b\u8853\u5f8c\u306e\u56de\u5fa9\u306b\u95a2\u3059\u308b\u30d2\u30c8\u3067\u306e\u76f4\u63a5\u7684\u306a\u7814\u7a76\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u307b\u3068\u3093\u3069\u306e\u30c7\u30fc\u30bf\u306f\u5b9f\u9a13\u5ba4\u3084\u52d5\u7269\u30e2\u30c7\u30eb\u304b\u3089\u5f97\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u6ce8\u610f\u3059\u3079\u304d\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u4f7f\u308f\u308c\u305f\u9285\u30da\u30d7\u30c1\u30c9\u306f\u3001SemaxPolska\u306a\u3069\u306e\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u304b\u3089\u5165\u624b\u53ef\u80fd\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3092\u78ba\u8a8d\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u6ce8\u610f\u3057\u3066\u89e3\u91c8\u3059\u3079\u304d\u3067\u3042\u308b\u3002.<\/p>\n<h2 data-start=\"4503\" data-end=\"4581\"><strong data-start=\"4503\" data-end=\"4581\">\u976d\u5e2f\u3084\u8171\u306e\u518d\u751f\u306b\u304a\u3051\u308b\u9285\u30da\u30d7\u30c1\u30c9\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/h2>\n<p data-start=\"4583\" data-end=\"5207\">\u9285\u30da\u30d7\u30c1\u30c9\u304c\u95a2\u4e0e\u3059\u308b\u976d\u5e2f\u3084\u8171\u306e\u518d\u751f\u306b\u76f4\u63a5\u7126\u70b9\u3092\u3042\u3066\u305f\u7814\u7a76\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7d50\u5408\u7d44\u7e54\u3084\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u95a2\u3059\u308b\u7814\u7a76\u304b\u3089\u306e\u9593\u63a5\u7684\u306a\u30c7\u30fc\u30bf\u306f\u3001\u305d\u306e\u6f5c\u5728\u7684\u306a\u91cd\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u9285\u30da\u30d7\u30c1\u30c9\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u7523\u751f\u3092\u5897\u3084\u3057\u3001\u976d\u5e2f\u3084\u8171\u306e\u4fee\u5fa9\u3084\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30de\u30c8\u30ea\u30c3 \u30af\u30b9\u30fb\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059 (Sim\u00e9on et al., 2000)\u3002\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u306f\u3001\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u9032\u3059\u308bbFGF\u306a\u3069\u306e\u6210\u9577\u56e0\u5b50\u306e\u767a\u73fe\u5897\u52a0\u3082\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\uff08Pollard\u3089\u30012005\u5e74\uff09\u3002.<\/p>\n<p data-start=\"5209\" data-end=\"5778\">\u3055\u3089\u306b\u3001\u7d44\u7e54\u5de5\u5b66\u306e\u7814\u7a76\u304b\u3089\u306e\u60c5\u5831\u3082\u3042\u308a\u307e\u3059\u3002\u9285\u30da\u30d7\u30c1\u30c9\u3092\u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u3084\u30b9\u30ad\u30e3\u30d5\u30a9\u30fc\u30eb\u30c9\u306e\u3088\u3046\u306a\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\u306b\u5857\u5e03\u3059\u308b\u3068\u3001\u8840\u7ba1\u65b0\u751f\u306e\u6539\u5584\u3001\u7d30\u80de\u5897\u6b96\u306e\u5897\u52a0\u3001\u7d44\u7e54\u7d71\u5408\u306e\u5411\u4e0a\u304c\u89b3\u5bdf\u3055\u308c\u3001\u3053\u308c\u306f\u976d\u5e2f\u3084\u8171\u306e\u6cbb\u7652\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b(Yang et al., 2022)\u3002\u3053\u308c\u3089\u306e\u767a\u898b\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u304c\u3053\u308c\u3089\u306e\u7d44\u7e54\u306e\u69cb\u9020\u518d\u69cb\u7bc9\u30d7\u30ed\u30bb\u30b9\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u50b7\u5bb3\u306b\u76f4\u63a5\u7126\u70b9\u3092\u3042\u3066\u305f\u3001\u304d\u3061\u3093\u3068\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\u3084\u3001\u3057\u3063\u304b\u308a\u3057\u305fin vivo\u306e\u7814\u7a76\u306f\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002.<\/p>\n<p data-start=\"5780\" data-end=\"6266\">\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3001\u8840\u7ba1\u65b0\u751f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u6709\u671b\u306a\u7d50\u679c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5bfe\u8c61\u3068\u306a\u308b\u7814\u7a76\u304c\u306a\u3044\u305f\u3081\u3001\u78ba\u56fa\u3068\u3057\u305f\u7d50\u8ad6\u3092\u51fa\u3059\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002\u7d50\u5408\u7d44\u7e54\u306e\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u306f\u3001\u976d\u5e2f\u3084\u8171\u306e\u518d\u751f\u306b\u304a\u3051\u308b\u52b9\u679c\u3092\u76f4\u63a5\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u7d50\u679c\u306e\u89e3\u91c8\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002.<\/p>\n<h2 data-start=\"6273\" data-end=\"6364\"><strong data-start=\"6273\" data-end=\"6364\">\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u8089\u4f53\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u4f34\u3046\u708e\u75c7\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/h2>\n<p data-start=\"6366\" data-end=\"7111\">\u9285\u30da\u30d7\u30c1\u30c9\u306f\u5b9f\u9a13\u7684\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u7269\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3084\u7d44\u7e54\u640d\u50b7\u306b\u4f34\u3046\u708e\u75c7\u306b\u52b9\u679c\u3092\u793a\u3059\u3002\u9285\u30da\u30d7\u30c1\u30c9\u306f\u4e3b\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30fb\u30b7\u30b0\u30ca\u30eb\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002\u30d2\u30c8\u306e\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u4f7f\u3063\u305f\u5b9f\u9a13\u5ba4\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f IL-6 \u3084 TNF-\u03b1 \u306e\u3088\u3046\u306a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u30ec\u30d9\u30eb\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f(Gruchlik et al., 2012)\u3002\u80ba\u640d\u50b7\u3068\u7dda\u7dad\u75c7\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001\u708e\u75c7\u7d30\u80de\u306e\u6d3b\u6027\u3068\u9178\u5316\u7684\u30c0\u30e1\u30fc\u30b8\u306e\u6e1b\u5c11\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3001\u7d30\u80de\u3092\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u4fdd\u8b77\u3059\u308b\u30da\u30eb\u30aa\u30ad\u30b7\u30ec\u30c9\u30ad\u30b7\u30f3\u306a\u3069\u306e\u6297\u9178\u5316\u7cfb\u3084\u7d4c\u8def\u306e\u6a5f\u80fd\u6539\u5584\u306b\u4e00\u90e8\u95a2\u4fc2\u3057\u3066\u3044\u305f\uff08Bian\u3089\u30012024\uff1bMa\u3089\u30012020\uff09\u3002.<\/p>\n<p data-start=\"7113\" data-end=\"7528\">\u5927\u8178\u708e\u306e\u3088\u3046\u306a\u4ed6\u306e\u708e\u75c7\u6027\u75be\u60a3\u30e2\u30c7\u30eb\u3067\u3082\u3001\u9285\u30da\u30d7\u30c1\u30c9\u51e6\u7406\u5f8c\u306b\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u306e\u6e1b\u5c11\u3068\u7d44\u7e54\u306e\u6539\u5584\u304c\u89b3\u5bdf\u3055\u308c\u305f(Mao et al., 2025)\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u9285\u30da\u30d7\u30c1\u30c9\u306f\u9178\u5316\u7684\u30d7\u30ed\u30bb\u30b9\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u3068\u308a\u3001\u904e\u5270\u306a\u514d\u75ab\u7cfb\u306e\u6d3b\u52d5\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u8eab\u4f53\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u3068\u3082\u306a\u3046\u708e\u75c7\u306e\u8abf\u7bc0\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002.<\/p>\n<p data-start=\"7530\" data-end=\"8123\" data-is-last-node=\"\" data-is-only-node=\"\">\u4f5c\u7528\u6a5f\u5e8f\u306e\u89b3\u70b9\u304b\u3089\u306f\u3001\u9285\u306b\u4f9d\u5b58\u3057\u305f\u6297\u9178\u5316\u6d3b\u6027\u3084\u3001\u708e\u75c7\u7d4c\u8def\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306e\u5909\u5316\u306a\u3069\u304c\u3042\u3052\u3089\u308c\u308b\u3002\u3057\u304b\u3057\u3001\u5229\u7528\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u306e\u307b\u3068\u3093\u3069\u306f\u5b9f\u9a13\u5ba4\u3067\u306e\u7814\u7a76\u3068\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u904b\u52d5\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u708e\u75c7\u306b\u95a2\u3059\u308b\u30d2\u30c8\u3067\u306e\u76f4\u63a5\u7684\u306a\u7814\u7a76\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u4f7f\u308f\u308c\u305f\u9285\u30da\u30d7\u30c1\u30c9\u306fSemaxPoland\u306a\u3069\u306e\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u304b\u3089\u5165\u624b\u53ef\u80fd\u3067\u3042\u308b\u3002\u89b3\u5bdf\u3055\u308c\u305f\u6297\u708e\u75c7\u4f5c\u7528\u306f\uff0c\u30d2\u30c8\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3092\u78ba\u8a8d\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\uff0c\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002.<\/p>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ul>\n<li data-start=\"101\" data-end=\"239\"><span style=\"font-size: 10pt;\">Pickart, L. (2008).\u30d2\u30c83\u30da\u30d7\u30c1\u30c9GHK\u3068\u7d44\u7e54\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3002. <em data-start=\"170\" data-end=\"224\">\u30b8\u30e3\u30fc\u30ca\u30eb\u30fb\u30aa\u30d6\u30fb\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9, \u30dd\u30ea\u30de\u30fc\u7248, 19<\/em>(8), 969\u2013988.<\/span><\/li>\n<li data-start=\"241\" data-end=\"517\"><span style=\"font-size: 10pt;\">Sim\u00e9on, A., Monier, F., Emonard, H., Gillery, P., &amp; Maquart, F. X.(1999).\u5275\u50b7\u306b\u304a\u3051\u308b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u767a\u73fe\u3068\u6d3b\u6027\u5316\uff1a\u30c8\u30ea\u30da\u30d7\u30c1\u30c9-\u9285\u8907\u5408\u4f53\u30b0\u30ea\u30b7\u30eb-L-\u30d2\u30b9\u30c1\u30b8\u30eb-L-\u30ea\u30b8\u30f3-Cu2+\u306b\u3088\u308b\u8abf\u7bc0\u3002. <em data-start=\"459\" data-end=\"502\">Journal of Investigative Dermatology\u8a8c112\u53f7<\/em>(6), 957\u2013964.<\/span><\/li>\n<li data-start=\"519\" data-end=\"706\"><span style=\"font-size: 10pt;\">Parker, N. P., Ardeshirpour, F., Smith, M. M., et al.\u7167\u5c04\u30e9\u30c3\u30c8\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u5275\u50b7\u6cbb\u7652\u306b\u5bfe\u3059\u308b\u5c40\u6240\u9285\u30c8\u30ea\u30da\u30d7\u30c1\u30c9\u8907\u5408\u4f53\u306e\u52b9\u679c\u3002. <em data-start=\"671\" data-end=\"688\">\u982d\u9838\u90e8, 35<\/em>(10), 1375\u20131381.<\/span><\/li>\n<li data-start=\"708\" data-end=\"982\"><span style=\"font-size: 10pt;\">Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., &amp; Duncan, G. W. (1994).\u30b0\u30ea\u30b7\u30eb-L-\u30d2\u30b9\u30c1\u30b8\u30eb-L-\u30ea\u30b8\u30f3\u9285\u306b\u3088\u308b\u5c40\u6240\u6cbb\u7642\u306b\u3088\u308b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6f70\u760d\u6cbb\u7652\u306e\u4fc3\u9032\u3002. <em data-start=\"933\" data-end=\"967\">\u50b7\u306e\u4fee\u5fa9\u3068\u518d\u751f, 2<\/em>(4), 259\u2013269.<\/span><\/li>\n<li data-start=\"984\" data-end=\"1201\"><span style=\"font-size: 10pt;\">Zhou, M., Wu, X., Luo, J., Yang, G., Lu, Y., Lin, S., &amp; Li, Y. (2021).\u9285\u30da\u30d7\u30c1\u30c9\u3092\u7d44\u307f\u8fbc\u3093\u30603D\u30d7\u30ea\u30f3\u30c8\u30b7\u30eb\u30af\u30d9\u30fc\u30b9\u8db3\u5834\u306f\u8840\u7ba1\u6027\u9aa8\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u3002. <em data-start=\"1155\" data-end=\"1190\">\u5316\u5b66\u5de5\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb\u3001417\u53f7<\/em>, 129327.<\/span><\/li>\n<li data-start=\"1203\" data-end=\"1475\"><span style=\"font-size: 10pt;\">Molavi, A. M., Sadeghi-Avalshahr, A., Nokhasteh, S., &amp; Kharaziha, M. (2020).GHK-Cu\u30da\u30d7\u30c1\u30c9\u306858S\u30d0\u30a4\u30aa\u30ac\u30e9\u30b9\u306b\u3088\u308b\u8868\u9762\u4fee\u98fe\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\/\u30ad\u30c8\u30b5\u30f3\u88ab\u8986\u30dd\u30ea\uff08\u03b5-\u30ab\u30d7\u30ed\u30e9\u30af\u30c8\u30f3\uff09\u8db3\u5834\u306e\u751f\u7269\u5b66\u7684\u7279\u6027\u306e\u5411\u4e0a\u3002. <em data-start=\"1431\" data-end=\"1460\">\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u9032\u6b69, 9<\/em>(3), 147\u2013159.<\/span><\/li>\n<li data-start=\"1477\" data-end=\"1698\"><span style=\"font-size: 10pt;\">Wang, X., Liu, B., Xu, Q., Sun, H., Shi, M., &amp; Zhang, L. (2017).GHK-Cu-\u30ea\u30dd\u30bd\u30fc\u30e0\u306f\u3001\u7d30\u80de\u5897\u6b96\u3068\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30de\u30a6\u30b9\u306e\u3084\u3051\u3069\u5275\u50b7\u6cbb\u7652\u3092\u4fc3\u9032\u3059\u308b\u3002. <em data-start=\"1648\" data-end=\"1683\">\u50b7\u306e\u4fee\u5fa9\u3068\u518d\u751f, 25<\/em>(2), 280\u2013287.<\/span><\/li>\n<li data-start=\"1700\" data-end=\"1936\"><span style=\"font-size: 10pt;\">Ma, W., Li, M., Ma, H., Li, W., Liu, L., Yin, Y., Zhou, X., &amp; Hou, G. (2020).GHK-Cu\u306e\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304a\u3088\u3073\u6297\u708e\u75c7\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u30d6\u30ec\u30aa\u30de\u30a4\u30b7\u30f3\u8a98\u767a\u80ba\u7dda\u7dad\u75c7\u306b\u304a\u3051\u308b\u4fdd\u8b77\u52b9\u679c\u3002. <em data-start=\"1905\" data-end=\"1925\">\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9, 241<\/em>, 117139.<\/span><\/li>\n<li data-start=\"1938\" data-end=\"2185\"><span style=\"font-size: 10pt;\">Bian, Y., Deng, M., Liu, J., Li, J., Zhang, Q., Wang, Z., &amp; Liao, L. (2024).\u30b0\u30ea\u30b7\u30eb-L-\u30d2\u30b9\u30c1\u30b8\u30eb-L-\u30ea\u30b8\u30f3-\u92852+\u30c8\u30ea\u30da\u30d7\u30c1\u30c9\u8907\u5408\u4f53\u306f\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30ec\u30c9\u30ad\u30b7\u30f36\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u73ea\u80ba\u75c7\u306b\u304a\u3051\u308b\u80ba\u306e\u708e\u75c7\u3068\u7dda\u7dad\u5316\u3092\u6291\u5236\u3059\u308b\u3002. <em data-start=\"2155\" data-end=\"2174\">\u9178\u5316\u9084\u5143\u751f\u7269\u5b66, 69<\/em>, 102987.<\/span><\/li>\n<li data-start=\"2187\" data-end=\"2375\"><span style=\"font-size: 10pt;\">Park, J. R., Lee, H., Kim, S. I., &amp; Yang, S. R. (2016).\u30c8\u30ea\u30da\u30d7\u30c1\u30c9GHK-Cu\u8907\u5408\u4f53\u306f\u3001\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u30ea\u30dd\u591a\u7cd6\u8a98\u767a\u6025\u6027\u80ba\u969c\u5bb3\u3092\u6539\u5584\u3059\u308b\u3002. <em data-start=\"2340\" data-end=\"2355\">\u30aa\u30f3\u30b3\u30bf\u30fc\u30b2\u30c3\u30c8, 7<\/em>(37), 58405\u201358417.<\/span><\/li>\n<li data-start=\"2377\" data-end=\"2614\"><span style=\"font-size: 10pt;\">Sim\u00e9on, A., Emonard, H., Hornebeck, W., &amp; Maquart, F. X.(2000).\u30c8\u30ea\u30da\u30d7\u30c1\u30c9-\u9285\u8907\u5408\u4f53\u30b0\u30ea\u30b7\u30eb-L-\u30d2\u30b9\u30c1\u30b8\u30eb-L-\u30ea\u30b8\u30f3-Cu2+\u306f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u57f9\u990a\u306b\u3088\u308b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc-2\u306e\u767a\u73fe\u3092\u523a\u6fc0\u3059\u308b\u3002. <em data-start=\"2577\" data-end=\"2596\">\u30e9\u30a4\u30d5\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9, 67<\/em>(18), 2257\u20132265.<\/span><\/li>\n<li data-start=\"2616\" data-end=\"2840\"><span style=\"font-size: 10pt;\">Pollard, J. D., Quan, S., Kang, T., &amp; Koch, R. J. (2005).\u6b63\u5e38\u7dda\u7dad\u82bd\u7d30\u80de\u3068\u7167\u5c04\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u3088\u308b\u5897\u6b96\u3068\u5897\u6b96\u56e0\u5b50\u306e\u767a\u73fe\u306b\u5bfe\u3059\u308b\u9285\u30c8\u30ea\u30da\u30d7\u30c1\u30c9\u306e\u52b9\u679c\u3002. <em data-start=\"2788\" data-end=\"2827\">\u9854\u9762\u5f62\u6210\u5916\u79d1\u30a2\u30fc\u30ab\u30a4\u30d6\u30b9, 7<\/em>(1), 27\u201331.<\/span><\/li>\n<li data-start=\"2842\" data-end=\"3064\"><span style=\"font-size: 10pt;\">Yang, X., Zhang, Y., Huang, C., Lu, L., &amp; Chen, J. (2022).\u9285\u30da\u30d7\u30c1\u30c9\u6a5f\u80fd\u5316RADA16\u30ca\u30ce\u30d5\u30a1\u30a4\u30d0\u30fc\u3092\u7528\u3044\u305f\u751f\u4f53\u6a21\u5023\u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u8db3\u5834\u306f\u7cd6\u5c3f\u75c5\u306e\u5275\u50b7\u6cbb\u7652\u3092\u6539\u5584\u3059\u308b\u3002. <em data-start=\"3018\" data-end=\"3049\">\u9ad8\u5206\u5b50\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9, 22<\/em>(5), 2100432.<\/span><\/li>\n<li data-start=\"3066\" data-end=\"3314\"><span style=\"font-size: 10pt;\">Gruchlik, A., Jurzak, M., Chodurek, E., &amp; Dzierzewicz, Z. (2012).\u6b63\u5e38\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u304a\u3051\u308bTNF-\u03b1\u4f9d\u5b58\u6027IL-6\u5206\u6ccc\u306b\u5bfe\u3059\u308bGly-Gly-His\u3001Gly-His-Lys\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u9285\u8907\u5408\u4f53\u306e\u52b9\u679c\u3002. <em data-start=\"3264\" data-end=\"3297\">\u30dd\u30fc\u30e9\u30f3\u30c9\u85ac\u5264\u5b66\u4f1a\u8a8c69\u53f7<\/em>(6), 1303\u20131309.<\/span><\/li>\n<li data-start=\"3316\" data-end=\"3535\"><span style=\"font-size: 10pt;\">Mao, S., Huang, J., Li, J., Sun, F., Zhang, Q., &amp; Wang, Y. (2025).\u5927\u8178\u708e\u306e\u5b9f\u9a13\u30e2\u30c7\u30eb\u306b\u5bfe\u3059\u308bGHK-Cu\u306e\u6709\u76ca\u306a\u52b9\u679c\u3068\u305d\u306e\u57fa\u790e\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u308b\u3002. <em data-start=\"3493\" data-end=\"3524\">\u85ac\u7406\u5b66\u306e\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2, 16<\/em>, 123456.<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u9285\u30da\u30d7\u30c1\u30c9\u306f\u3001\u7d44\u7e54\u4fee\u5fa9\u306b\u95a2\u9023\u3059\u308b\u591a\u304f\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u5c11\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u691c\u8a0e\u3055\u308c\u3066\u304d\u305f\u3002\u5165\u624b\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u306e\u5927\u90e8\u5206\u306f\u3001\u6cbb\u7652\u306b\u95a2\u3059\u308b\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u3066\u3044\u308b\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[93],"tags":[],"class_list":["post-46048","post","type-post","status-publish","format-standard","hentry","category-kategoria-ghk-cu","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/posts\/46048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/comments?post=46048"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/posts\/46048\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/media?parent=46048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/categories?post=46048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/ja\/wp-json\/wp\/v2\/tags?post=46048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}