\uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc(GHK-Cu)\uc5d0 \ub300\ud55c \ud604\uc7ac \uc5f0\uad6c\ub294 \uc804\uc784\uc0c1 \ubaa8\ub378\uc5d0 \ub300\ud55c \uc758\uc874\ub3c4\uac00 \ub192\uace0, \uc5f0\uad6c \uc124\uacc4\uc758 \ucc28\uc774, \ubcf5\uc7a1\ud55c \uc0dd\ubb3c\ud559\uc801 \uc2dc\uc2a4\ud15c\uc5d0\uc11c\uc758 \uc791\uc6a9\uc5d0 \ub300\ud55c \ubd88\uc644\uc804\ud55c \uc774\ud574\ub85c \uc778\ud574 \uba87 \uac00\uc9c0 \uc911\uc694\ud55c \ud55c\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\uc6a9 \uac00\ub2a5\ud55c \ub300\ubd80\ubd84\uc758 \ub370\uc774\ud130\ub294 \uc2e4\ud5d8\uc2e4(\uc2dc\ud5d8\uad00 \ub0b4) \ubc0f \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c \ub098\uc628 \uac83\uc774\uba70, \uc798 \ud1b5\uc81c\ub41c \uc778\uac04 \uc5f0\uad6c\ub294 \uc544\uc9c1 \uc81c\ud55c\uc801\uc785\ub2c8\ub2e4.<\/p>\n
\ud55c \uac00\uc9c0 \ud070 \ud55c\uacc4\ub294 \ub9ce\uc740 \uacb0\uacfc\uac00 \uc0dd\uc950\ub098 \uc950\uc640 \uac19\uc740 \ub3d9\ubb3c \ubaa8\ub378\uc744 \uae30\ubc18\uc73c\ub85c \ud55c\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub178\ud654 \uc0dd\uc950 \ub610\ub294 \ub1cc \uc190\uc0c1 \ubaa8\ub378\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 \uae30\uc5b5\ub825 \uac1c\uc120, \uc5fc\uc99d \uac10\uc18c, \uc2e0\uacbd\uc138\ud3ec \uc0dd\uc874\uc728 \uac1c\uc120\uc774 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \ubaa8\ub378\uc740 \ub2e8\uc21c\ud558\uba70 \uc778\uac04\uc758 \uc0dd\ubb3c\ud559\uc744 \uc644\uc804\ud788 \ubc18\uc601\ud558\uc9c0 \ubabb\ud569\ub2c8\ub2e4. \uc2e0\uc9c4\ub300\uc0ac, \ub1cc \uad6c\uc870 \ubc0f \uc218\uba85\uc758 \ucc28\uc774\ub294 \ud2b9\ud788 \ub178\ud654 \ubc0f \uc2e0\uacbd \ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \ub9e5\ub77d\uc5d0\uc11c \uc774\ub7ec\ud55c \uacb0\uacfc\ub97c \uc778\uac04\uc5d0\uac8c \uc801\uc6a9\ud560 \uc218 \uc788\ub294 \uc815\ub3c4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n
\ub610 \ub2e4\ub978 \ubb38\uc81c\ub294 \uc5f0\uad6c\uc5d0\uc11c \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc0ac\uc6a9\ub41c \ubc29\uc2dd\uc5d0 \uc77c\uad00\uc131\uc774 \uc5c6\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc5f0\uad6c\ub9c8\ub2e4 \uc6a9\ub7c9, \ud22c\uc5ec \ubc29\ubc95, \uc81c\ud615\uc774 \ub2ec\ub790\uc2b5\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\ub294 \ube44\uac15 \ub0b4 \ud22c\uc5ec, \ubcf5\uac15 \ub0b4 \uc8fc\uc0ac, \ud53c\ubd80 \uad6d\uc18c \ub3c4\ud3ec \ub4f1\uc774 \ud3ec\ud568\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uac01 \ubc29\ubc95\uc740 \uccb4\ub0b4 \ud761\uc218 \ubc0f \ubd84\ud3ec \ud328\ud134\uc774 \ub2e4\ub985\ub2c8\ub2e4. \ud45c\uc900\ud654\ub41c \ud22c\uc5ec \uc694\ubc95\uc774 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \uc5f0\uad6c \uacb0\uacfc\uc640 \uc7ac\ud604\uc131\uc744 \ube44\uad50\ud558\uae30\uac00 \uc5b4\ub835\uc2b5\ub2c8\ub2e4.<\/p>\n
\uc791\uc6a9 \uae30\uc804\uc758 \uad00\uc810\uc5d0\uc11c \uc5ec\ub7ec \uac00\uc9c0 \uc0dd\ubb3c\ud559\uc801 \uacbd\ub85c\uac00 \ud655\uc778\ub418\uc5c8\uc9c0\ub9cc \uc9c0\ubc30\uc801\uc778 \ub2e8\uc77c \uba54\ucee4\ub2c8\uc998\uc740 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\ub294 \uc138\ud3ec \uc0dd\uc874\uacfc \uad00\ub828\ub41c PI3K\/Akt \uacbd\ub85c, miR-146a-3p\uc640 \uac19\uc740 \ub9c8\uc774\ud06c\ub85cRNA\uc758 \uc870\uc808, TNF-\u03b1 \ubc0f IL-1\u03b2\uc640 \uac19\uc740 \uc5fc\uc99d \ub9c8\ucee4\uc758 \ubcc0\ud654 \ub4f1 \uc5ec\ub7ec \uc2dc\uc2a4\ud15c\uc744 \ud1b5\ud574 \ub3d9\uc2dc\uc5d0 \uc791\uc6a9\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4. \uad11\ubc94\uc704\ud55c \ud6a8\uacfc\ub294 \ud765\ubbf8\ub86d\uc9c0\ub9cc \uc778\uacfc \uad00\uacc4\ub97c \uba85\ud655\ud558\uac8c \uaddc\uba85\ud558\uae30\ub294 \uc5b4\ub835\uc2b5\ub2c8\ub2e4.<\/p>\n
\uc5f0\uad6c \uc124\uacc4\uc5d0\ub3c4 \uc81c\ud55c\uc774 \uc801\uc6a9\ub429\ub2c8\ub2e4. \uc77c\ubd80 \uc2e4\ud5d8\uc740 \uc18c\uaddc\ubaa8 \uc5f0\uad6c \uadf8\ub8f9\uc774\ub098 \uc9e7\uc740 \uad00\ucc30 \uae30\uac04, \ud2b9\ud788 \ub3d9\ubb3c \uc5f0\uad6c\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc77c\ubd80 \uacb0\uacfc\ub294 \uc608\ube44 \uc5f0\uad6c \ub610\ub294 \ucd9c\ud310 \uc804 \ucd9c\ud310\ubb3c\uc5d0\uc11c \ub098\uc628 \uac83\uc73c\ub85c, \ud56d\uc0c1 \uc644\uc804\ud55c \uacfc\ud559\uc801 \ub3d9\ub8cc \uac80\ud1a0 \uacfc\uc815\uc744 \uac70\uce58\uc9c0 \uc54a\uc740 \uacbd\uc6b0\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n
\uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\uc758 \ud22c\uc5ec \ubc0f \ud761\uc218 \ubc29\uc2dd\ub3c4 \uc911\uc694\ud55c \uc694\uc18c\uc785\ub2c8\ub2e4. \uacbd\uad6c \ud22c\uc5ec \ud6c4\uc5d0\ub294 \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \ub5a8\uc5b4\uc9c0\ubbc0\ub85c \uc18c\ud654 \uc911\uc5d0 \uc548\uc815\uc801\uc73c\ub85c \uc720\uc9c0\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ube44\uac15 \ub0b4 \ud22c\uc5ec\uc640 \uac19\uc740 \ub300\uccb4 \ubc29\ubc95\uc740 \ub3d9\ubb3c \ubaa8\ub378\uacfc \uc0ac\ub78c\uc5d0\uc11c \ub2e4\ub974\uac8c \uc791\uc6a9\ud560 \uc218 \uc788\ub294 \ud2b9\uc815 \uc0dd\ubb3c\ud559\uc801 \uacbd\ub85c\uc5d0 \uc758\uc874\ud569\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 \uc2e4\uc81c \uc870\uac74\uc5d0\uc11c \ud45c\uc801 \uc870\uc9c1\uc5d0 \ub300\ud55c \ud3a9\ud0c0\uc774\ub4dc \uc804\ub2ec\uc758 \ud6a8\ub2a5\uc5d0 \ub300\ud55c \ubd88\ud655\uc2e4\uc131\uc774 \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \uc2e4\ud5d8 \uc5f0\uad6c\uc5d0\uc11c \uad00\ucc30\ub41c \uc0dd\ubb3c\ud559\uc801 \uacbd\ub85c\uc758 \ubcc0\ud654\ub294 \uc778\uccb4\uc5d0\uc11c\uc758 \uce58\ub8cc \ud6a8\uacfc\ub97c \ud655\uc778\ud558\ub294 \uac83\uc774 \uc544\ub2c8\uba70 \ud574\ub2f9 \uc5f0\uad6c\uc758 \ub9e5\ub77d\uc5d0\uc11c\ub9cc \ud574\uc11d\ub418\uc5b4\uc57c \ud55c\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n
\uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\uc5d0 \ub300\ud55c \ub3d9\ubb3c \uc5f0\uad6c\ub294 \uc778\uccb4\uc5d0\uc11c\uc758 \uc791\uc6a9\uc5d0 \ub300\ud55c \uadc0\uc911\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud558\uc9c0\ub9cc, \uc778\uccb4\uc5d0\uc11c\uc758 \ud6a8\uacfc\ub97c \uc608\uce21\ud558\ub294 \ub370\ub294 \uc2e0\ub8b0\uc131\uc774 \uc81c\ud55c\uc801\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc720\ud615\uc758 \uc5f0\uad6c\ub294 \ud0d0\uc0c9\uc801 \uc5f0\uad6c\uc774\ubbc0\ub85c \uac00\uc124\uc744 \uc138\uc6b0\uace0 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\ud574\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\uc9c0\ub9cc \uc778\uac04\uc5d0 \ub300\ud55c \uc791\uc6a9\uc744 \ud655\uc2e4\ud558\uac8c \ud655\uc778\ud558\uc9c0\ub294 \ubabb\ud569\ub2c8\ub2e4.<\/p>\n
\ud1b5\uc81c\ub41c \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\ub294 \uc7ac\ud604 \uac00\ub2a5\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\ub294 \uae30\uc5b5\ub825 \ubc0f \ud559\uc2b5 \ub2a5\ub825 \uac1c\uc120, \uc5fc\uc99d \uac10\uc18c, \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uac10\uc18c, \uc2e0\uacbd \uc138\ud3ec \uc0dd\uc874\uc728 \uac1c\uc120 \ub4f1\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub178\ud654 \uc950\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\ub97c \ube44\uac15 \ub0b4 \ud22c\uc5ec\ud55c \uacb0\uacfc \uae30\uc5b5\ub825 \ud14c\uc2a4\ud2b8 \uc218\ud589 \ub2a5\ub825\uc774 \ud5a5\uc0c1\ub418\uace0 \uc5fc\uc99d \ubc0f \uc2e0\uacbd \uc190\uc0c1 \ud45c\uc9c0\uc790\uac00 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \ub1cc\ub0b4 \ucd9c\ud608\uacfc \uac19\uc740 \ub1cc \uc190\uc0c1 \uc950 \ubaa8\ub378\uc5d0\uc11c\ub294 \uc7ac\uc0dd\uc774 \uac1c\uc120\ub418\uace0 \ub1cc \ubd80\uc885\uc774 \uac10\uc18c\ud558\ub294 \uac83\uc774 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n
\ub3d9\ubb3c \uc5f0\uad6c \uacb0\uacfc\uc758 \uc77c\uad00\uc131\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc778\uac04\uc5d0 \ub300\ud55c \uc801\uc6a9\uc744 \uc81c\ud55c\ud558\ub294 \uba87 \uac00\uc9c0 \uc694\uc778\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uccab\uc9f8, \ub3d9\ubb3c \ubaa8\ub378\uc740 \uace0\ub3c4\ub85c \ud1b5\uc81c\ub418\uace0 \ub2e8\uc21c\ud569\ub2c8\ub2e4. \uc720\uc804\uc801 \ucc28\uc774, \uc0dd\ud65c \ubc29\uc2dd, \ud658\uacbd \ubc0f \ub3d9\ubc18 \uc9c8\ud658\uacfc \uac19\uc740 \uc694\uc778\uc774 \uacb0\uacfc\uc5d0 \ub2e4\ub974\uac8c \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub294 \uc778\uac04 \uc9d1\ub2e8\uc758 \ubcf5\uc7a1\uc131\uc744 \ubc18\uc601\ud558\uc9c0 \ubabb\ud569\ub2c8\ub2e4.<\/p>\n
\ub458\uc9f8, \uc9c1\uc811\uc801\uc778 \uc6a9\ub7c9 \ubcc0\ud658\uc774 \uc5b4\ub835\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c\ub294 \uccb4\uc911(mg\/kg)\uc73c\ub85c \ud658\uc0b0\ud55c \uc6a9\ub7c9\uc744 \uc0ac\uc6a9\ud558\ub294\ub370, \uc774\ub294 \uc0ac\ub78c\uc758 \ubcf5\uc6a9\ub7c9\uacfc \uc9c1\uc811\uc801\uc73c\ub85c \uc77c\uce58\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc2e0\uc9c4\ub300\uc0ac\uc640 \uc57d\ub3d9\ud559, \uc989 \ubb3c\uc9c8\uc774 \ud761\uc218, \ubd84\ud3ec \ubc0f \uc81c\uac70\ub418\ub294 \ubc29\uc2dd\uc758 \ucc28\uc774\ub85c \uc778\ud574 \uc0ac\ub78c\uc5d0\uac8c \uc801\uc808\ud558\uace0 \uc548\uc804\ud55c \uc6a9\ub7c9\uc744 \uacb0\uc815\ud558\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4.<\/p>\n
\uc14b\uc9f8, \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\uc758 \ud22c\uc5ec \ubc29\uc2dd\uc740 \uc885\uc5d0 \ub530\ub77c \ub2e4\ub97c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc0dd\uc950\uc758 \ube44\uac15 \ub0b4 \ud22c\uc5ec\ub294 \ud6c4\uac01 \uad00\ub828 \uacbd\ub85c\ub97c \ud1b5\ud574 \ub1cc\uc5d0 \ube44\uad50\uc801 \uc9c1\uc811\uc801\uc73c\ub85c \uc811\uadfc\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc0ac\ub78c\uc758 \uacbd\uc6b0 \uc774 \uacbd\ub85c\uac00 \ud6a8\uc728\uc801\uc774\uac70\ub098 \uc7ac\ud604\uc131\uc774 \ub5a8\uc5b4\uc9c8 \uc218 \uc788\uc73c\uba70, \uc774\ub294 \ub1cc \uc870\uc9c1\uc5d0 \ub3c4\ub2ec\ud558\ub294 \ud3a9\ud0c0\uc774\ub4dc\uc758 \uc591\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/p>\n
\ub610 \ub2e4\ub978 \uce21\uba74\uc740 \uacb0\uacfc\ub97c \ud3c9\uac00\ud558\ub294 \ubc29\uc2dd\uc785\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c\ub294 \ubbf8\ub85c\uc640 \uac19\uc740 \ud589\ub3d9 \ud14c\uc2a4\ud2b8\ub97c \uc0ac\uc6a9\ud558\uac70\ub098 \uc870\uc9c1\uc758 \uc0dd\ubb3c\ud559\uc801 \ub9c8\ucee4\ub97c \ubd84\uc11d\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc9c0\ud45c\ub294 \uc778\uc9c0 \uae30\ub2a5 \uac1c\uc120\uc774\ub098 \uc9c8\ubcd1 \uc9c4\ud589 \uc18d\ub3c4 \ub454\ud654\uc640 \uac19\uc774 \uc778\uac04\uc5d0\uac8c \uc784\uc0c1\uc801\uc73c\ub85c \uad00\ub828\ub41c \ud6a8\uacfc\ub85c \ud56d\uc0c1 \ud574\uc11d\ub418\uc9c0\ub294 \uc54a\ub294 \uac04\uc811\uc801\uc778 \uc9c0\ud45c\uc785\ub2c8\ub2e4.<\/p>\n
\uc774\ub7ec\ud55c \ud55c\uacc4\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub3d9\ubb3c \uc5f0\uad6c\ub294 \uc5ec\uc804\ud788 \uac00\uce58\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc7a0\uc7ac\uc801\uc778 \uc0dd\ubb3c\ud559\uc801 \ud6a8\uacfc\ub97c \ud655\uc778\ud558\uace0, \uac00\ub2a5\ud55c \uc791\uc6a9 \uba54\ucee4\ub2c8\uc998\uc744 \uaddc\uba85\ud558\uba70, \ucd94\uac00 \uc5f0\uad6c\ub97c \uc704\ud55c \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc0ac\ub78c\uc5d0\uac8c\ub3c4 \ub3d9\uc77c\ud55c \ubc29\uc2dd\uc73c\ub85c \uc791\uc6a9\ud55c\ub2e4\ub294 \uc99d\uac70\ub294 \uc81c\uacf5\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n
\uc5f0\uad6c \ud658\uacbd\uc5d0\uc11c \uc0ac\uc6a9\ub41c \uad6c\ub9ac \ud3a9\ud0c0\uc774\ub4dc\ub294 SemaxPolska\uc640 \uac19\uc740 \uacf5\uae09\uc5c5\uccb4\ub97c \ud1b5\ud574 \uad6c\uc785\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c \uacb0\uacfc\uac00 \uc0ac\ub78c\uc5d0 \ub300\ud55c \ud6a8\ub2a5\uc744 \uc785\uc99d\ud558\ub294 \uac83\uc740 \uc544\ub2c8\uba70 \uc798 \uc124\uacc4\ub41c \uc784\uc0c1\uc2dc\ud5d8\uc744 \ud1b5\ud55c \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud569\ub2c8\ub2e4.<\/p>\n
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