{"id":49667,"date":"2026-06-06T09:47:04","date_gmt":"2026-06-06T07:47:04","guid":{"rendered":"https:\/\/semaxpolska.com\/?p=49667"},"modified":"2026-06-01T09:55:56","modified_gmt":"2026-06-01T07:55:56","slug":"%ec%86%a1%ea%b3%bc%ec%84%a0%ec%9d%80-%ec%96%b4%eb%96%bb%ea%b2%8c-%ec%9e%91%ec%9a%a9%ed%95%98%eb%82%98%ec%9a%94","status":"publish","type":"post","link":"https:\/\/bioevidencehub.com\/ko\/jak-dziala-pinealon\/","title":{"rendered":"\ud30c\uc778\uc54c\ub860\uc740 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud558\ub098\uc694?"},"content":{"rendered":"

\ud30c\uc778\uc54c\ub860(Pinealon)\uc740 \uc0dd\uccb4 \uc870\uc808 \ud3a9\ud0c0\uc774\ub4dc\ub85c, \uc2e4\ud5d8 \uc5f0\uad6c\uc5d0\uc11c \uc2e0\uacbd \uc138\ud3ec \ubcf4\ud638, \uc138\ud3ec \uacfc\uc815 \uc870\uc808 \ubc0f \uac74\uac15\ud55c \ub178\ud654 \uc9c0\uc6d0\uc5d0 \ub300\ud55c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\uac01\uc801\uc778 \uc791\uc6a9 \uae30\uc804 \ub355\ubd84\uc5d0 \uc810\uc810 \ub354 \ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \ub2e4\uc74c\uacfc \uac19\uc740 \uc9c8\ubb38\uc744 \ud0d0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4: \u201e\ud30c\uc778\uc54c\ub860\uc740 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud558\ub098\uc694?\u201d<\/strong>, \ud2b9\ud788 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4, \uc720\uc804\uc790 \ubc1c\ud604, \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c \ubc0f \uc2e0\uacbd\uacc4 \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uc5b4.<\/p>\n

\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc870\uc808<\/h3>\n

\ud30c\uc778\uc54c\ub860\uc758 \uc791\uc6a9 \uba54\ucee4\ub2c8\uc998 \uc911 \uac00\uc7a5 \uc798 \uc5f0\uad6c\ub41c \uac83 \uc911 \ud558\ub098\ub294 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc870\uc808\ud558\uace0 \ud65c\uc131\uc0b0\uc18c\uc885(ROS)\uc758 \ucd95\uc801\uc744 \uc5b5\uc81c\ud558\ub294 \ub2a5\ub825\uc785\ub2c8\ub2e4. \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub294 \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uc0dd\uc131\uc774 \uc2e0\uccb4\uc758 \uc790\uc5f0\uc801\uc778 \ud56d\uc0b0\ud654 \uae30\uc804\uc744 \ucd08\uacfc\ud560 \ub54c \ubc1c\uc0dd\ud558\uba70, \uc774\ub294 \ub2e8\ubc31\uc9c8, \uc9c0\uc9c8, DNA \ubc0f \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uc190\uc0c1\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \ub192\uc740 \uc218\uc900\uc758 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc2e0\uccb4\uc758 \ub178\ud654, \uc778\uc9c0 \uae30\ub2a5 \uc800\ud558 \ubc0f \uc2e0\uacbd \ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \ubc1c\ubcd1\uc5d0 \uae30\uc5ec\ud558\ub294 \uc694\uc778 \uc911 \ud558\ub098\ub85c \ub110\ub9ac \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8\uc2e4 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, \ud30c\uc778\uc54c\ub860\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \ubc1b\uc740 \uc18c\ub1cc\uc758 \uc54c\uac31\uc774 \uc2e0\uacbd\uc138\ud3ec, \ud638\uc911\uad6c \ubc0f PC12 \uac08\uc0c9\uc138\ud3ec\uc885 \uc138\ud3ec\uc5d0\uc11c ROS\uc758 \ucd95\uc801\uc744 \uc6a9\ub7c9 \uc758\uc874\uc801\uc73c\ub85c \uc5b5\uc81c\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4 (1).<\/p>\n

Khavinson\uacfc \ub3d9\ub8cc\ub4e4\uc740 Pinealon\uc774 \uc77c\ubc18\uc801\uc73c\ub85c \uacfc\ub3c4\ud55c \uc790\uc720 \ub77c\ub514\uce7c \uc0dd\uc131\uc744 \uc720\ubc1c\ud558\ub294 \uc870\uac74\uc5d0\uc11c \uc0b0\ud654 \uc190\uc0c1\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc138\ud3ec \uc0dd\uc874\uc728\uc744 \ud5a5\uc0c1\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc785\uc99d\ud588\ub2e4(1). \uc774 \ud3a9\ud0c0\uc774\ub294 \ub610\ud55c \uad34\uc0ac \uc138\ud3ec\uc758 \ube44\uc728\uc744 \uac10\uc18c\uc2dc\ucf30\ub294\ub370, \uc774\ub294 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud558\ub294 \uc791\uc6a9\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ud30c\uc778\uc54c\ub860\uc774 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uad00\ub828\ub41c \uc190\uc0c1\uc744 \uc904\uc774\uace0 \ud658\uacbd\uc801 \ubc0f \ub300\uc0ac\uc801 \uc694\uc778\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc744 \ub192\uc784\uc73c\ub85c\uc368 \uc815\uc0c1\uc801\uc778 \uc138\ud3ec \uae30\ub2a5 \uc720\uc9c0\ub97c \uc9c0\uc6d0\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \uacb0\uacfc\uac00 \uad00\ucc30\ub418\uc5c8\ub2e4. \ud0dc\uc544\uae30 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d\uc5d0 \ub178\ucd9c\ub41c \uc790\uc190\uc5d0\uc11c, \ud30c\uc778\uc54c\ub860\uc740 \uc18c\ub1cc \ub274\ub7f0\uc758 \uc138\ud3ec \ub0b4 ROS \uc218\uce58\ub97c \ub0ae\ucd94\uace0 \uacfc\uc0b0\ud654\uc218\uc18c \ub178\ucd9c\ub85c \uc778\ud55c \uc0b0\ud654\uc801 \uc190\uc0c1\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc744 \ub192\uc600\uc2b5\ub2c8\ub2e4(2). \uc5f0\uad6c \uc800\uc790\ub4e4\uc740 \ud30c\uc778\uc54c\ub860\uc758 \uc2e0\uacbd \ubcf4\ud638 \ud2b9\uc131\uc774 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc81c\ud55c\ud558\uace0 \ub274\ub7f0\uc758 \uc0dd\uc874\uc744 \uc9c0\uc6d0\ud558\ub294 \ub2a5\ub825\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\ub2e4\ub294 \uacb0\ub860\uc744 \ub0b4\ub838\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc77c\ubd80 \uc5f0\uad6c\uc790\ub4e4\uc740 \ub610\ud55c \ud30c\uc778\uc54c\ub860\uc774 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \ub514\uc2a4\ubba4\ud0c0\uc81c(SOD2) \ubc0f \uae00\ub8e8\ud0c0\ud2f0\uc628 \ud37c\uc625\uc2dc\ub2e4\uc81c(GPX1)\uc640 \uac19\uc740 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \ud3ec\ud568\ud558\uc5ec \uc2e0\uccb4\uc758 \ub0b4\uc778\uc131 \ud56d\uc0b0\ud654 \uc2dc\uc2a4\ud15c\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud569\ub2c8\ub2e4. \ube44\ub85d \uc778\uac04\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ub098\uc628 \uc9c1\uc811\uc801\uc778 \uc99d\uac70\ub294 \uc5ec\uc804\ud788 \uc81c\ud55c\uc801\uc774\uc9c0\ub9cc, \uc774\ub7ec\ud55c \ud56d\uc0b0\ud654 \ud2b9\uc131\uc774 \uad00\ucc30\ub41c \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\uc640 \uac74\uac15\ud55c \ub178\ud654\ub97c \uc9c0\uc6d0\ud558\ub294 \ub370 \uae30\uc5ec\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \uc5ec\uaca8\uc9d1\ub2c8\ub2e4(1,2).<\/p>\n

MAPK\/ERK \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c<\/h3>\n

\ud30c\uc778\uc54c\ub860\uc740 \uc138\ud3ec\uc758 \uc801\uc751\uacfc \uc0dd\uc874\uc744 \ub2f4\ub2f9\ud558\ub294 \uc138\ud3ec \ub0b4 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce68\uc73c\ub85c\uc368 \uc0dd\ubb3c\ud559\uc801 \ud6a8\uacfc\ub97c \uc720\ubc1c\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8 \uc5f0\uad6c\uc5d0\uc11c \ud655\uc778\ub41c \uacbd\ub85c \uc911 \ud558\ub098\ub294 \uc138\ud3ec \uc678 \uc2e0\ud638\uc5d0 \uc758\ud574 \uc870\uc808\ub418\ub294 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c \uacbd\ub85c (MAPK\/ERK) \uacbd\ub85c\ub85c, \uc774\ub294 \uc138\ud3ec \uc131\uc7a5, \ubd84\ud654, \uc2a4\ud2b8\ub808\uc2a4 \ubc18\uc751 \ubc0f \uc0dd\uc874 \uacfc\uc815\uc758 \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

Khavinson\uacfc \ub3d9\ub8cc\ub4e4\uc774 \uc218\ud589\ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, Pinealon\uc758 \ubcf4\ud638 \ud6a8\uacfc\ub294 ERK1\/2 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc758 \ud65c\uc131\ud654 \uc9c0\uc5f0\uacfc \uad00\ub828\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4(1). ERK \ub2e8\ubc31\uc9c8\uc740 \uc138\ud3ec \ud45c\uba74\uc5d0\uc11c \ud575\uc73c\ub85c \uc2e0\ud638\ub97c \uc804\ub2ec\ud558\uc5ec \uc720\uc804\uc790 \ubc1c\ud604 \ud504\ub85c\uadf8\ub7a8\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uba70, \uc138\ud3ec \uc801\uc751\uc758 \ud575\uc2ec \uc870\uc808\uc790 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. ERK1\/2\uc758 \ud65c\uc131\ud654\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc138\ud3ec \uc0dd\uc874\uc728 \ud5a5\uc0c1 \ubc0f \ubd88\ub9ac\ud55c \ud658\uacbd \uc870\uac74\uc5d0 \ub300\ud55c \uc800\ud56d\uc131 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc774 \uc5f0\uad6c\ub294 \ub610\ud55c \ud30c\uc778\uc54c\ub860\uc774 \uc138\ud3ec \uc8fc\uae30 \uc870\uc808\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uba74\uc11c \ub3d9\uc2dc\uc5d0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc138\ud3ec \uc0ac\uba78\uc744 \uc5b5\uc81c\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4(1). \uc774\ub7ec\ud55c \uad00\ucc30 \uacb0\uacfc\ub294 \uc774 \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc138\ud3ec\ub97c \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, MAPK\/ERK \uacbd\ub85c\ub97c \ud1b5\ud574 \uc801\uc751 \ubc0f \uc7ac\uc0dd \uacfc\uc815\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uc774\ub7ec\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \uac74\uac15\ud55c \ub178\ud654, \uc2e0\uacbd \uc138\ud3ec\uc758 \uba74\uc5ed\ub825, \uc778\uc9c0 \uae30\ub2a5 \uc720\uc9c0\uc640 \uad00\ub828\ub41c \uad00\ucc30\ub41c \ud6a8\uacfc\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc720\uc804\uc790 \uc870\uc808\uacfc \ud6c4\uc131\uc720\uc804\uc801 \ud65c\ub3d9<\/h3>\n

\ud30c\uc778\uc54c\ub860\uc758 \uac00\uc7a5 \ub450\ub4dc\ub7ec\uc9c4 \ud2b9\uc9d5 \uc911 \ud558\ub098\ub294 DNA\uc640 \uc9c1\uc811 \uc0c1\ud638\uc791\uc6a9\ud558\uc5ec \uc720\uc804\uc790 \ubc1c\ud604\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub294 \uc7a0\uc7ac\uc801 \ub2a5\ub825\uc785\ub2c8\ub2e4. Fedoreyeva\uc640 \ub3d9\ub8cc\ub4e4\uc758 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, \ud615\uad11 \ud45c\uc9c0\ub41c \ud30c\uc778\uc54c\ub860 \ubd84\uc790\ub294 \uc0b4\uc544\uc788\ub294 \uc138\ud3ec\ub85c \uce68\ud22c\ud558\uc5ec \uc138\ud3ec\uc9c8, \uc138\ud3ec\ud575 \ubc0f \ud575\uc18c\uccb4\uc5d0 \uc704\uce58\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(3). \uc774 \ubc1c\uacac\uc740 \ud30c\uc778\uc54c\ub860\uc774 \uc138\ud3ec \ud45c\uba74\uc5d0 \uc704\uce58\ud55c \uc218\uc6a9\uccb4\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc720\uc804\uc790 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub294 \uc138\ud3ec \uad6c\uc870\uc5d0\ub3c4 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\ucd94\uac00 \ubd84\uc11d \uacb0\uacfc, \ud30c\uc778\uc54c\ub860\uc740 \ud2b9\uc815 DNA \ub274\ud074\ub808\uc624\ud2f0\ub4dc \uc11c\uc5f4 \ubc0f \ub370\uc625\uc2dc\ub9ac\ubcf4\uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud2f0\ub4dc\uc640 \uc120\ud0dd\uc801\uc73c\ub85c \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4(3). \uc774 \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc720\uc804\uc790 \ubc1c\ud604 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub294 DNA \ubaa8\ud2f0\ud504\uc5d0 \uc6b0\uc120\uc801\uc73c\ub85c \uacb0\ud569\ud558\uc5ec \uc11c\uc5f4\uc744 \uc778\uc2dd\ud558\ub294 \ub2a5\ub825\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ub610\ud55c \ud30c\uc778\uc54c\ub860\uc774 \ub2e4\uc591\ud55c DNA \uba54\ud2f8\ud654 \ud328\ud134\uc744 \uad6c\ubcc4\ud560 \uc218 \uc788\uc74c\uc744 \uad00\ucc30\ud588\uc73c\uba70, \uc774\ub294 \uc720\uc804 \ubb3c\uc9c8\uacfc\uc758 \ub9e4\uc6b0 \uc120\ud0dd\uc801\uc778 \uc0c1\ud638 \uc791\uc6a9\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uacb0\uacfc\ub85c \uc778\ud574 \ud30c\uc778\uc54c\ub860\uc740 \ud6c4\uc131\uc720\uc804\ud559\uc801 \uc0dd\uccb4\uc870\uc808 \ud3a9\ud0c0\uc774\ub4dc\ub85c \ubd84\ub958\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud30c\uc778\uc54c\ub860\uc740 DNA \uad6c\uc870 \uc790\uccb4\ub97c \ubcc0\ud654\uc2dc\ud0a4\ub294 \ub300\uc2e0, \uc138\ud3ec \uc801\uc751, \uc2a4\ud2b8\ub808\uc2a4 \uc800\ud56d\uc131 \ubc0f \uc2e0\uacbd \uc138\ud3ec \uae30\ub2a5\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\uc758 \ud65c\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4 (3). \uc774\ub7ec\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \ub2e8 \uc138 \uac1c\uc758 \uc544\ubbf8\ub178\uc0b0\uc73c\ub85c\ub9cc \uad6c\uc131\ub41c \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc\uac00 \uc5b4\ub5bb\uac8c \uc2e0\uccb4\uc758 \ub2e4\uc591\ud55c \uc870\uc9c1\uacfc \uc2dc\uc2a4\ud15c\uc5d0\uc11c \uce21\uc815 \uac00\ub2a5\ud55c \uc0dd\ubb3c\ud559\uc801 \ud6a8\uacfc\ub97c \uc720\ubc1c\ud560 \uc218 \uc788\ub294\uc9c0\ub97c \ubd80\ubd84\uc801\uc73c\ub85c \uc124\uba85\ud574 \uc904 \uc218 \uc788\ub2e4.<\/p>\n

\ud6c4\uc131\uc720\uc804\ud559\uc801 \uc870\uc808\uc740 \ub178\ud654 \uacfc\uc815, \uc2e0\uacbd \ubcf4\ud638 \ubc0f \uc138\ud3ec \uae30\ub2a5 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ubbc0\ub85c, Pinealon\uc774 \uc720\uc804\uc790 \ubc1c\ud604\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub2a5\ub825\uc740 \uc774 \uc81c\ud488\uc758 \uac00\uc7a5 \ud765\ubbf8\ub85c\uc6b4 \uacfc\ud559\uc801 \ud2b9\uc131 \uc911 \ud558\ub098\ub85c \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uc0c1\ud638\uc791\uc6a9\uc774 \uc778\uccb4 \uac74\uac15\uc5d0 \ubbf8\uce58\ub294 \uc911\uc694\uc131\uc744 \uc644\uc804\ud788 \ud3c9\uac00\ud558\uae30 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\uc138\ub85c\ud1a0\ub2cc \ubc1c\ud604\uacfc \uc2e0\uacbd\ud654\ud559\uc801 \uc870\uc808<\/h3>\n

\ud30c\uc778\uc54c\ub860\uc758 \ub610 \ub2e4\ub978 \uc791\uc6a9 \uae30\uc804\uc73c\ub85c \uc81c\uc2dc\ub418\ub294 \uac83\uc740 \ub1cc \uc138\ud3ec \ub0b4 \uc138\ub85c\ud1a0\ub2cc \uc0dd\uc131\uc758 \uc870\uc808\uc785\ub2c8\ub2e4. \uc138\ub85c\ud1a0\ub2cc\uc740 \uae30\ubd84, \uc218\uba74, \uae30\uc5b5, \ud559\uc2b5 \uacfc\uc815, \uc815\uc11c\uc801 \uade0\ud615 \ubc0f \uc804\ubc18\uc801\uc778 \uc2e0\uacbd\ud559\uc801 \uac74\uac15\uc758 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub294 \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\uc785\ub2c8\ub2e4.<\/p>\n

Khavinson\uacfc \ub3d9\ub8cc\ub4e4\uc740 \ub178\ud654 \ub1cc\uc5d0\uc11c \uc720\ub798\ud55c \ub300\ub1cc \ud53c\uc9c8 \uc138\ud3ec \ubc30\uc591 \uc2e4\ud5d8\uc744 \ud1b5\ud574, EDR \ud3a9\ud0c0\uc774\ub4dc\uac00 \uc138\ub85c\ud1a0\ub2cc \ud569\uc131 \uc18d\ub3c4\ub97c \uc81c\ud55c\ud558\ub294 \ud6a8\uc18c\uc778 \ud2b8\ub9bd\ud1a0\ud310 \ud558\uc774\ub4dc\ub85d\uc2e4\ub77c\uc81c\ub97c \uc554\ud638\ud654\ud558\ub294 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc99d\uac00\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc785\uc99d\ud588\ub2e4(4). \ubd84\uc790 \ub3c4\ud0b9 \ubd84\uc11d \uacb0\uacfc, \ud30c\uc778\uc54c\ub860(Pinealon)\uc774 \uc774 \uc720\uc804\uc790\uc640 \uad00\ub828\ub41c \ud2b9\uc815 \ub274\ud074\ub808\uc624\ud2f0\ub4dc \uc11c\uc5f4\uacfc \uc0c1\ud638\uc791\uc6a9\ud558\uc5ec, \ud6c4\uc131\uc720\uc804\ud559\uc801 \uae30\uc804\uc744 \ud1b5\ud574 \uc138\ub85c\ud1a0\ub2cc \uc0dd\uc131\uc744 \uc99d\uac00\uc2dc\ud0ac \uac00\ub2a5\uc131\uc774 \uc2dc\uc0ac\ub418\uc5c8\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \ud30c\uc778\uc54c\ub860\uc774 \uc138\ub85c\ud1a0\ub2cc \ubc1c\ud604\uc744 \uc870\uc808\ud558\ub294 \uc5ed\ud560\uc744 \ud558\uba70, \uc774\ub7ec\ud55c \uc791\uc6a9\uc774 \uad00\ucc30\ub41c \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\uc640 \uac74\uac15\ud55c \ub178\ud654\ub97c \uc9c0\uc6d0\ud558\ub294 \ub370 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4\uace0 \ubc1d\ud614\ub2e4(4). \uc138\ub85c\ud1a0\ub2cc \ud65c\uc131\uc758 \uc99d\uac00\ub294 \ub1cc\uc758 \uc815\uc0c1\uc801\uc778 \ub178\ud654, \uc2e0\uacbd\uc138\ud3ec \uac04\uc758 \uc18c\ud1b5, \uc815\uc2e0\uc801 \uc6f0\ube59 \ubc0f \uc778\uc9c0 \uae30\ub2a5\uc744 \uc9c0\uc6d0\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\uc138\ub85c\ud1a0\ub2cc\uacfc \uad00\ub828\ub41c \uc774\ub7ec\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \ud30c\uc778\uc54c\ub860\uc774 \uc218\uba74\uacfc \uc778\uc9c0 \uae30\ub2a5\uc5d0 \ubbf8\uce60 \uc218 \uc788\ub294 \uc7a0\uc7ac\uc801 \uc601\ud5a5\uc5d0 \ub300\ud55c \uad00\uc2ec\ub3c4 \ubd88\ub7ec\uc77c\uc73c\ucf30\uc2b5\ub2c8\ub2e4. \uc0ac\uc6a9\uc790\ub4e4\uc758 \ud6c4\uae30\uc5d0\uc11c \uc218\uba74\uc758 \uc9c8 \ud5a5\uc0c1\uacfc \ub354 \uc0dd\uc0dd\ud55c \uafc8\uc5d0 \ub300\ud55c \uc5b8\uae09\uc774 \uc790\uc8fc \ub098\ud0c0\ub098\uc9c0\ub9cc, \uc774\ub7ec\ud55c \ud6a8\uacfc\uc5d0 \ub300\ud55c \ud1b5\uc81c\ub41c \uc784\uc0c1 \uc5f0\uad6c\ub294 \uc5ec\uc804\ud788 \uc81c\ud55c\uc801\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud604\uc7ac \ub370\uc774\ud130\ub294 \uc138\ud3ec \uc218\uc900\uc5d0\uc11c \ud30c\uc778\uc54c\ub860\uc774 \uc138\ub85c\ud1a0\ub2cc \uad00\ub828 \uacbd\ub85c\uc5d0 \uad00\uc5ec\ud568\uc744 \ub4b7\ubc1b\uce68\ud558\uc9c0\ub9cc, \uc218\uba74\uc774\ub098 \uc778\uc9c0 \uae30\ub2a5\uc5d0 \ub300\ud55c \uc784\uc0c1\uc801 \ud6a8\uacfc\ub97c \uba85\ud655\ud788 \uc785\uc99d\ud558\uae30\uc5d0\ub294 \ubd80\uc871\ud569\ub2c8\ub2e4.<\/p>\n

\ud30c\uc778\uc54c\ub860\uacfc \uc2e0\uacbd \ubcf4\ud638<\/h3>\n

\uc2e0\uacbd \ubcf4\ud638\ub294 \ud30c\uc778\uc54c\ub860\uc758 \uc791\uc6a9\uacfc \uad00\ub828\ud558\uc5ec \uac00\uc7a5 \uc9d1\uc911\uc801\uc73c\ub85c \uc5f0\uad6c\ub418\uace0 \uc788\ub294 \ubd84\uc57c \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. \uc218\ub9ce\uc740 \uc2e4\ud5d8\uc2e4 \uc5f0\uad6c\uc640 \ub3d9\ubb3c \uc2e4\ud5d8 \uacb0\uacfc, \ud30c\uc778\uc54c\ub860\uc774 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c\ubd80\ud130 \ub274\ub7f0\uc744 \ubcf4\ud638\ud558\uace0, \uc2e0\uacbd \uc138\ud3ec \uc190\uc0c1\uc744 \uc904\uc774\uba70, \uc2dc\ub0c5\uc2a4 \uad6c\uc870\uc758 \ubb34\uacb0\uc131\uc744 \uc720\uc9c0\ud558\uace0, \uc804\ubc18\uc801\uc778 \ub1cc \uae30\ub2a5\uc744 \uc9c0\uc6d0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4(1,2,5).<\/p>\n

\uac00\uc7a5 \uac15\ub825\ud55c \uc99d\uac70 \uc911 \uc77c\ubd80\ub294 \uc0b0\uc804 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d, \uc989 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc99d\uac00 \ubc0f \uc2e0\uacbd \ubc1c\ub2ec \uc7a5\uc560\uc640 \uad00\ub828\ub41c \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uc5f0\uad6c\uc5d0\uc11c \ube44\ub86f\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Arutjunyan\uacfc \ub3d9\ub8cc\ub4e4\uc740 Pinealon\uc774 \ud0dc\uc544\uae30 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d\uc5d0 \ub178\ucd9c\ub41c \ud6c4\uc190\uc758 \uc778\uc9c0 \ub2a5\ub825\uc744 \ud604\uc800\ud788 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \ub3d9\uc2dc\uc5d0 \uc2e0\uacbd \uc138\ud3ec \uc190\uc0c1\uc744 \uc81c\ud55c\ud55c\ub2e4\ub294 \uac83\uc744 \uc785\uc99d\ud588\ub2e4(2). Pinealon\uc744 \ud22c\uc5ec\ubc1b\uc740 \ub3d9\ubb3c\uc5d0\uc11c \ucc44\ucde8\ud55c \uc18c\ub1cc \ub274\ub7f0\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc218\uc900\uc774 \ub0ae\uace0, \uad34\uc0ac \uc138\ud3ec \uc218\uac00 \uc801\uc73c\uba70, \uacfc\uc0b0\ud654\uc218\uc18c\ub85c \uc778\ud55c \uc190\uc0c1\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc774 \ub354 \ub192\uc740 \ud2b9\uc9d5\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ud30c\uc778\uc54c\ub860\uc774 \uc5f4\uc545\ud55c \uc0dd\ub9ac\ud559\uc801 \uc870\uac74\uc5d0\uc11c \ub274\ub7f0\uc758 \uc0dd\uc874\uc728\uc744 \ub192\uc778\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n

\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \uad00\ud55c \uc5f0\uad6c \uacb0\uacfc\ub3c4 \uc774\ub97c \ub4b7\ubc1b\uce68\ud55c\ub2e4. \uc544\ubc00\ub85c\uc774\ub4dc\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc2dc\ub0c5\uc2a4 \ub3c5\uc131 \uc138\ud3ec \ubaa8\ub378\uc5d0\uc11c Kraskovskaya\uc640 \ub3d9\ub8cc\ub4e4\uc740 Pinealon\uc774 \uc131\uc219\ud55c \u201e\ubc84\uc12f\ud615\u201d \uc758 \uc218\ub97c 71% \uc99d\uac00\uc2dc\ucf1c, \uadf8 \ubc00\ub3c4\ub97c \uac74\uac15\ud55c \ub300\uc870\uad70 \uc138\ud3ec\uc5d0\uc11c \uad00\ucc30\ub41c \uc218\uc900\uc5d0 \uac00\uae5d\uac8c \ud68c\ubcf5\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4(5). \uc218\uc9c0\uc0c1 \ub3cc\uae30\ub294 \ub274\ub7f0 \uac04\uc758 \uc18c\ud1b5\uc744 \uac00\ub2a5\ud558\uac8c \ud558\ub294 \ud575\uc2ec \uad6c\uc870\ubb3c\uc774\uba70, \ud559\uc2b5 \ubc0f \uae30\uc5b5 \uacfc\uc815\uc5d0\uc11c \uc911\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uad6c\uc870\ubb3c\uc758 \ubcf4\uc874\uc740 \uc2e0\uacbd \ubcf4\ud638 \ud65c\uc131\uc758 \uc911\uc694\ud55c \uc9c0\ud45c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4.<\/p>\n

Khavinson\uacfc \ub3d9\ub8cc\ub4e4\uc774 \uc218\ud589\ud55c \ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c Pinealon\uc758 \uc791\uc6a9\uc744 \ubd84\uc11d\ud588\uc73c\uba70, \ub274\ub7f0\uc758 \uc800\ud56d\uc131\uacfc \uc138\ud3ec\uc758 \uc801\uc751 \ub2a5\ub825 \ud5a5\uc0c1\uacfc \uad00\ub828\ub41c \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc785\uc99d\ud588\ub2e4(6). \uc800\uc790\ub4e4\uc740 \ud30c\uc778\uc54c\ub860\uc744 \uc138\ud3ec \uae30\ub2a5\uc744 \uc870\uc808\ud558\uace0 \ub178\ud654\uc640 \uad00\ub828\ub41c \ud1f4\ud589\uc73c\ub85c\ubd80\ud130 \ub274\ub7f0\uc744 \ubcf4\ud638\ud560 \uc218 \uc788\ub294 \uc9e7\uc740 \ud6c4\uc131\uc720\uc804\ud559\uc801 \ud3a9\ud0c0\uc774\ub4dc \uadf8\ub8f9\uc5d0 \ud3ec\ud568\uc2dc\ucf30\ub2e4.<\/p>\n

\ud30c\uc778\uc54c\ub860\uc758 \uc2e0\uacbd \ubcf4\ud638 \uc791\uc6a9\uc740 \uc11c\ub85c \uc0c1\ud638 \ubcf4\uc644\uc801\uc778 \uba87 \uac00\uc9c0 \uae30\uc804\uc5d0 \uae30\uc778\ud558\ub294 \uac83\uc73c\ub85c \uc5ec\uaca8\uc9d1\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\ub294 \ud65c\uc131\uc0b0\uc18c\uc885\uc758 \uc0dd\uc131 \uc5b5\uc81c, \uc0b0\ud654\uc801 \uc190\uc0c1 \uac10\uc18c, \uc138\ud3ec \uc0dd\uc874\uc744 \ub2f4\ub2f9\ud558\ub294 \uacbd\ub85c\uc758 \ud65c\uc131\ud654, \uc2dc\ub0c5\uc2a4 \uad6c\uc870 \ubcf4\ud638, \uadf8\ub9ac\uace0 \uc2e0\uacbd\uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5 \uc720\uc9c0\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\uc758 \uc870\uc808 \ub4f1\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4(1\u20133,5,6). \uc774\ub7ec\ud55c \uc791\uc6a9\ub4e4\uc740 \uc885\ud569\uc801\uc73c\ub85c \uc2e0\uacbd\uac00\uc18c\uc131, \uc989 \ub1cc\uac00 \uc801\uc751\ud558\uace0 \uc7ac\uc870\uc9c1\ub418\uba70 \uc0c8\ub85c\uc6b4 \uc2e0\uacbd \uc5f0\uacb0\uc744 \ud615\uc131\ud558\ub294 \ub2a5\ub825\uc744 \uc9c0\uc6d0\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ub1cc \uc0b0\uc18c \uacf5\uae09\uc774 \uac1c\uc120\ub41c\ub2e4\ub294 \uc9c1\uc811\uc801\uc778 \uc99d\uac70\ub294 \uc544\uc9c1 \uc81c\ud55c\uc801\uc774\uc9c0\ub9cc, \uba87\uba87 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud30c\uc778\uc54c\ub860(Pinealon)\uc774 \ub300\uc0ac \ubc0f \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ub300\ud55c \uc2e0\uacbd\uc138\ud3ec\uc758 \uc800\ud56d\uc131\uc744 \ub192\uc5ec, \uac04\uc811\uc801\uc73c\ub85c \ub1cc\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uacfc \uc138\ud3ec \uc218\uc900\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc9c0\uc6d0\ud560 \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud558\uace0 \uc788\ub2e4(1,2). \uadf8\ub7ec\ub098 \uad00\ucc30\ub41c \uc2e4\ud5d8\uc801 \ud6a8\uacfc\uac00 \uc778\uac04\uc5d0\uac8c \uc2e4\uc9c8\uc801\uc778 \uc774\uc810\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\uc804\ubc18\uc801\uc73c\ub85c \ubcfc \ub54c, \ucd5c\uadfc \uc5f0\uad6c\ub4e4\uc740 \ud30c\uc778\uc54c\ub860(Pinealon)\uc774 \uc778\uc9c0 \ub178\ud654, \uc2e0\uacbd \ud1f4\ud589, \uc2e0\uacbd \uc138\ud3ec\uc758 \uba74\uc5ed\ub825 \ubc0f \ub1cc \uac74\uac15 \uc99d\uc9c4\uacfc \uad00\ub828\ud574 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\ub294 \uc720\ub9dd\ud55c \uc2e0\uacbd \ubcf4\ud638 \ud3a9\ud0c0\uc774\ub4dc\ub85c \uc81c\uc2dc\ud558\uace0 \uc788\ub2e4. \uadf8\ub7ec\ub098 \ub300\ubd80\ubd84\uc758 \uae30\uc874 \uc99d\uac70\ub294 \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ube44\ub86f\ub41c \uac83\uc774\uba70, \ud30c\uc778\uc54c\ub860\uc758 \uce58\ub8cc\uc801 \uc7a0\uc7ac\ub825\uc744 \uc785\uc99d\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc5ec\uc804\ud788 \ub300\uaddc\ubaa8 \uc778\uccb4 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud574\uc57c \ud55c\ub2e4.<\/p>\n

\ud30c\uc778\uc54c\ub860\uacfc \uc778\uc9c0 \uae30\ub2a5<\/h3>\n

\ud30c\uc778\uc54c\ub860\uacfc \uad00\ub828\ud558\uc5ec \uac00\uc7a5 \ub110\ub9ac \ub17c\uc758\ub418\ub294 \uc7a0\uc7ac\uc801 \uc774\uc810\uc73c\ub85c\ub294 \ud559\uc2b5, \uae30\uc5b5, \uc778\uc9c0 \ub2a5\ub825 \ubc0f \uc804\ubc18\uc801\uc778 \ub1cc \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ube44\ub85d \uc778\uac04\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \ub370\uc774\ud130\ub294 \uc544\uc9c1 \uc81c\ud55c\uc801\uc774\uc9c0\ub9cc, \uba87 \uac00\uc9c0 \ub3d9\ubb3c \uc5f0\uad6c\ub294 \ud30c\uc778\uc54c\ub860\uc774 \uc778\uc9c0 \ubc0f \uc2e0\uacbd\ud559\uc801 \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ub300\ud55c \uadc0\uc911\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud558\uace0 \uc788\ub2e4(2,6).<\/p>\n

\uac00\uc7a5 \uc911\uc694\ud55c \uc5f0\uad6c \uc911 \ud558\ub098\ub294 Arutjunyana\uc640 \ub3d9\ub8cc\ub4e4\uc774 \uc218\ud589\ud55c \uac83\uc73c\ub85c, \ud0dc\uc544\uae30 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d \uc950 \ubaa8\ub378\uc744 \ud65c\uc6a9\ud588\ub2e4. \uc774 \uc0c1\ud0dc\ub294 \uc778\uc9c0 \ubc1c\ub2ec\uc5d0 \ubd80\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc218\uc900\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4(2). \uc5f0\uad6c\uc9c4\uc740 \uacf5\uac04 \ud559\uc2b5 \ubc0f \uae30\uc5b5\ub825\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \uc2e4\ud5d8 \ubc29\ubc95\uc778 \ubaa8\ub9ac\uc2a4 \uc218\uc911 \ubbf8\ub85c \ud14c\uc2a4\ud2b8\ub97c \ud1b5\ud574 \uc778\uc9c0 \uae30\ub2a5\uc744 \ud3c9\uac00\ud588\ub2e4. \ud0dc\uc544\uae30 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d\uc5d0 \ub178\ucd9c\ub41c \ub3d9\ubb3c\ub4e4\uc740 \uac74\uac15\ud55c \ub300\uc870\uad70\uc5d0 \ube44\ud574 \ub354 \ub0ae\uc740 \uc810\uc218\ub97c \ubc1b\uc558\uace0, \ub354 \ub290\ub9ac\uac8c \ud5e4\uc5c4\ucce4\uc73c\uba70, \uc228\uaca8\uc9c4 \ud50c\ub7ab\ud3fc\uc744 \ucc3e\ub294 \ub370 \ub354 \ub9ce\uc740 \uc2dc\uac04\uc774 \uac78\ub838\uc2b5\ub2c8\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \ud30c\uc778\uc54c\ub860(Pinealon)\uc744 \ud22c\uc5ec\ubc1b\uc740 \uc5b4\ubbf8\uc758 \uc0c8\ub07c\ub4e4\uc740 \uc778\uc9c0 \ub2a5\ub825\uc774 \ud604\uc800\ud788 \ud5a5\uc0c1\ub41c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4(2). \uc774 \ub3d9\ubb3c\ub4e4\uc740 \ub354 \ub098\uc740 \uacf5\uac04 \uc9c0\uac01 \ub2a5\ub825, \ub354 \ub192\uc740 \ud559\uc2b5 \ub2a5\ub825, \ub354 \ube60\ub978 \ud50c\ub7ab\ud3fc \ucc3e\uae30 \ub2a5\ub825, \uadf8\ub9ac\uace0 \uac74\uac15\ud55c \ub300\uc870\uad70\uc5d0\uc11c \uad00\ucc30\ub41c \uac83\uacfc \ub354 \uc720\uc0ac\ud55c \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uac1c\uc120\uc740 \ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778 \uc218\uce58\uac00 \uc9c0\uc18d\uc801\uc73c\ub85c \ub192\uc740 \uc0c1\ud0dc\uc5d0\uc11c\ub3c4 \ub098\ud0c0\ub0ac\ub294\ub370, \uc774\ub294 \ud30c\uc778\uc54c\ub860\uc758 \uc791\uc6a9\uc774 \uadfc\ubcf8\uc801\uc778 \ub300\uc0ac \uc7a5\uc560\uc758 \uad50\uc815\uc774 \uc544\ub2cc \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\uc640 \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n

\uc5f0\uad6c \uc800\uc790\ub4e4\uc740 \ud30c\uc778\uc54c\ub860\uc774 \ubc1c\ub2ec \uc911\uc778 \ub1cc\uc5d0\uc11c \ub274\ub7f0\uc758 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc800\ud56d\uc131\uc744 \ub192\uc774\uace0 \uc138\ud3ec \uc190\uc0c1\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \ud559\uc2b5 \ud6a8\uc728\uacfc \uae30\uc5b5 \uad00\ub828 \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ucf30\ub2e4\uace0 \uacb0\ub860\uc9c0\uc5c8\ub2e4(2). \ub610\ud55c \uc774 \ud3a9\ud0c0\uc774\ub294 \ud65c\uc131\uc0b0\uc18c\uc885(ROS)\uc758 \ucd95\uc801\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc18c\ub1cc \uc2e0\uacbd\uc138\ud3ec\ub97c \uc0b0\ud654 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud568\uc73c\ub85c\uc368, \uad00\ucc30\ub41c \uc778\uc9c0 \uae30\ub2a5 \uac1c\uc120\uc5d0 \ub300\ud55c \uc0dd\ubb3c\ud559\uc801 \uadfc\uac70\ub97c \uc81c\uc2dc\ud588\ub2e4.<\/p>\n

\uc54c\uce20\ud558\uc774\uba38\ubcd1 \ubaa8\ub378\uc5d0\uc11c \uc5bb\uc740 \uc99d\uac70\ub4e4\uc740 \uc778\uc9c0 \uae30\ub2a5 \uc720\uc9c0\uc5d0 \uc788\uc5b4 \ud30c\uc778\uc54c\ub860\uc758 \uc7a0\uc7ac\uc801 \uc5ed\ud560\uc744 \ucd94\uac00\ub85c \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4. \ud574\ub9c8 \ub274\ub7f0\uc5d0\uc11c \uad00\ucc30\ub41c \uc815\uc0c1\uc801\uc778 \uc218\uc0c1\ub3cc\uae30 \ubc00\ub3c4\uc758 \ud68c\ubcf5\uc740, \uc774\ub7ec\ud55c \uad6c\uc870\uac00 \ud559\uc2b5\uacfc \uc815\ubcf4 \uc800\uc7a5\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\uae30 \ub54c\ubb38\uc5d0 \uc2dc\ub0c5\uc2a4 \ud1b5\uc2e0 \ubc0f \uae30\uc5b5 \uacfc\uc815\uc758 \uac1c\uc120\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4 (5). \uc218\uc0c1\ub3cc\uae30\uc758 \ubcf4\uc874\uc740 \uc885\uc885 \ub354 \ub192\uc740 \uc2e0\uacbd\uac00\uc18c\uc131\uacfc \ub178\ud654 \ubc0f \uc2e0\uacbd\ud1f4\ud589 \uacfc\uc815\uc5d0 \ub300\ud55c \uc778\uc9c0 \uae30\ub2a5\uc758 \ub354 \ub098\uc740 \uc800\ud56d\uc131\uacfc \uc5f0\uad00\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac\uc758 \uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74, \ud30c\uc778\uc54c\ub860\uc740 \ud559\uc2b5 \ub2a5\ub825, \uae30\uc5b5 \ud615\uc131, \uacf5\uac04 \uc9c0\uac01, \uc2dc\ub0c5\uc2a4 \ubb34\uacb0\uc131 \ubc0f \uc2e0\uacbd \uc138\ud3ec\uc758 \uc801\uc751\uc744 \ud3ec\ud568\ud55c \uc778\uc9c0 \uae30\ub2a5\uc758 \ub2e4\uc591\ud55c \uce21\uba74\uc744 \uc9c0\uc6d0\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud6a8\uacfc\ub294 \ud56d\uc0b0\ud654 \uc791\uc6a9, \uc2e0\uacbd \ubcf4\ud638, \uc2e0\uacbd \uc138\ud3ec \uc0dd\uc874\uc728 \uc99d\uc9c4, \uadf8\ub9ac\uace0 \ub1cc \uae30\ub2a5\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790 \uc870\uc808 \uac04\uc758 \uc0c1\ud638\uc791\uc6a9\uc5d0\uc11c \ube44\ub86f\ub41c \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4(1\u20136).<\/p>\n

\uc0ac\uc6a9\uc790\ub4e4\uc758 \ud6c4\uae30\uc5d0\uc11c \uc9d1\uc911\ub825 \ud5a5\uc0c1, \uc815\uc2e0\uc774 \ub9d1\uc544\uc9d0, \uc218\uba74\uc758 \uc9c8 \uac1c\uc120, \ud639\uc740 \ub354 \uc0dd\uc0dd\ud55c \uafc8\uc5d0 \ub300\ud55c \uc5b8\uae09\uc774 \uc790\uc8fc \ub098\ud0c0\ub098\uc9c0\ub9cc, \uc774\ub7ec\ud55c \uad00\ucc30 \uacb0\uacfc\ub294 \uc544\uc9c1 \ub300\uaddc\ubaa8 \ub300\uc870\uad70 \uc784\uc0c1 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc785\uc99d\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud604\uc7ac Pinealon\uc774 \uc778\uc9c0 \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ub300\ud55c \uacb0\ub860\uc740 \uc8fc\ub85c \uc2e4\ud5d8\uc801 \ubc0f \uc804\uc784\uc0c1 \uc5f0\uad6c \uacb0\uacfc\uc5d0 \uadfc\uac70\ud574\uc57c \ud558\uba70, \uc785\uc99d\ub41c \uc784\uc0c1\uc801 \ud6a8\uacfc\uc5d0 \uadfc\uac70\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4.<\/p>\n

\uc694\uc57d\ud558\uc790\uba74, \ud604\uc7ac\uae4c\uc9c0\uc758 \uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \ud30c\uc778\uc54c\ub860\uc740 \ud2b9\ud788 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4, \ub178\ud654 \uacfc\uc815 \ub610\ub294 \uc2e0\uacbd\ud559\uc801 \uc7a5\uc560\uc640 \uad00\ub828\ub41c \uc0c1\ud669\uc5d0\uc11c \uc778\uc9c0 \uae30\ub2a5\uacfc \ub1cc \uac74\uac15\uc744 \uc99d\uc9c4\uc2dc\ud0ac \uc218 \uc788\ub294 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \uc9c0\ub2cc \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uacb0\uacfc\uac00 \uc2e4\uc81c \uc778\uc9c0 \uae30\ub2a5 \uac1c\uc120\uc73c\ub85c \uc5b4\ub290 \uc815\ub3c4 \uc774\uc5b4\uc9c0\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc778\uac04\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \ucd94\uac00\uc801\uc778 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\uba74\ucc45 \uc870\ud56d<\/h3>\n

\uc774 \uae30\uc0ac\uc5d0 \uc18c\uac1c\ub41c \ub0b4\uc6a9\uc740 \uc624\ub85c\uc9c0 \uad50\uc721 \ubc0f \uc815\ubcf4 \uc81c\uacf5\uc744 \ubaa9\uc801\uc73c\ub85c \ud558\uba70, \uacf5\uac1c\ub41c \uacfc\ud559 \ubb38\ud5cc\uc744 \ubc14\ud0d5\uc73c\ub85c \ud569\ub2c8\ub2e4. \uc774\ub294 \uc758\ud559\uc801 \uc870\uc5b8, \uc9c4\ub2e8 \ub610\ub294 \uce58\ub8cc \uad8c\uace0\ub97c \uc758\ubbf8\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. Pinealon\uc740 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc73c\ub85c\ubd80\ud130 \uc5b4\ub5a0\ud55c \uc9c8\ubcd1\uc758 \uce58\ub8cc, \uc608\ubc29 \ub610\ub294 \uc9c4\ub2e8\uc744 \uc704\ud55c \uc6a9\ub3c4\ub85c\ub3c4 \uc2b9\uc778\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc774\uc6a9 \uac00\ub2a5\ud55c \ub370\uc774\ud130\uc758 \ub300\ubd80\ubd84\uc740 \uc2e4\ud5d8\uc2e4 \uc5f0\uad6c, \ub3d9\ubb3c \uc2e4\ud5d8 \ubc0f \uc81c\ud55c\uc801\uc778 \uc778\uccb4 \uc5f0\uad6c\uc5d0\uc11c \ube44\ub86f\ub418\uc5c8\uc73c\ubbc0\ub85c, \uc774 \ud3a9\ud0c0\uc774\ub4dc\uc758 \uc791\uc6a9 \uae30\uc804\uc744 \uc644\uc804\ud788 \uc774\ud574\ud558\uace0 \uc548\uc804\uc131 \ubc0f \uc720\ud6a8\uc131\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. Semax Polska\uc640 \uac19\uc740 \uacf5\uae09\uc5c5\uccb4\uac00 \uc81c\uacf5\ud558\ub294 \ud30c\uc778\uc54c\ub860(Pinealon) \ud568\uc720 \uc5f0\uad6c\uc6a9 \uc81c\ud488\uc740 \uc624\ub85c\uc9c0 \uc2e4\ud5d8\uc2e4 \ubc0f \uacfc\ud559 \uc5f0\uad6c\uc6a9\uc73c\ub85c\ub9cc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc778\uccb4 \uc0ac\uc6a9\uc774\ub098 \uce58\ub8cc \ubaa9\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\uc5b4\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4.<\/p>\n

\ucc38\uc870<\/h4>\n

(1)<\/strong> Khavinson, V., Ribakova, Y., Trofimova, S., \uc678. (2011). \uc1a1\ub85c\ubc84\uc12f\uc740 \ud65c\uc131\uc0b0\uc18c \uc218\uc900\uc744 \uc5b5\uc81c\ud558\uace0 \uc99d\uc2dd \uacfc\uc815\uc744 \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \uc138\ud3ec \uc0dd\uc874\uc728\uc744 \ub192\uc778\ub2e4. Rejuvenation Research, 14(5), 517\u2013523.<\/span>
\uc800\ub110 \ub9c1\ud06c: https:\/\/journals.sagepub.com\/doi\/abs\/10.1089\/rej.2011.1172<\/a><\/span><\/p>\n

(2)<\/strong> Arutjunyan, A. V., Kozina, L. S., Stvolinsky, S. L., Bulygina, E. R., Mashkina, A. P., & Khavinson, V. K. (2012). \uc1a1\uacfc\uc120\uc740 \ud0dc\uc544\uae30 \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d\uc73c\ub85c\ubd80\ud130 \uc950\uc758 \uc0c8\ub07c\ub97c \ubcf4\ud638\ud55c\ub2e4. International Journal of Peptides, 2012, 109757.<\/span>
DOI:10.1155\/2012\/109757 <\/a><\/span>PMC \uc804\ubb38: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3342713\/<\/a><\/span><\/p>\n

(3)<\/strong> Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K., & Vanyushin, B. F. (2011). HeLa \uc138\ud3ec\uc5d0\uc11c \ud615\uad11 \ud45c\uc9c0\ub41c \ub2e8\ud3b8 \ud3a9\ud0c0\uc774\ub4dc\uc758 \ud575 \uce68\ud22c \ubc0f \uc2dc\ud5d8\uad00 \ub0b4 \ub370\uc625\uc2dc\ub9ac\ubcf4\uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud2f0\ub4dc \ubc0f DNA\uc640\uc758 \ud2b9\uc774\uc801 \uc0c1\ud638\uc791\uc6a9. Biochemistry (Moscow), 76(11), 1210\u20131219.<\/span>
\uc800\ub110 \ub9c1\ud06c: https:\/\/link.springer.com\/article\/10.1134\/S0006297911110022<\/a><\/span><\/p>\n

(4)<\/strong> Khavinson, V. K., Lin\u2019kova, N. S., Tarnovskaya, S. I., Umnov, R. S., Elashkina, E. V., & Durnova, A. O. (2014). \ub2e8\ud3b8 \ud3a9\ud0c0\uc774\ub4dc\uac00 \ub300\ub1cc \ud53c\uc9c8 \uc138\ud3ec\uc5d0\uc11c \uc138\ub85c\ud1a0\ub2cc \ubc1c\ud604\uc744 \uc790\uadf9\ud55c\ub2e4. Bulletin of Experimental Biology and Medicine, 157(1), 77\u201380.<\/span>
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/24909721\/<\/a><\/span><\/p>\n

(5)<\/strong> Kraskovskaya, N. A., Kukanova, E. O., Lin\u2019kova, N. S., Popugaeva, E. A., & \ud558\ube48\uc2a8, V. K. (2017). \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc\uac00 \uccb4\uc678\uc5d0\uc11c \ubaa8\ub378\ub9c1\ub41c \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uc870\uac74 \ud558\uc5d0\uc11c \uc2e0\uacbd\ub3cc\uae30\uc758 \uc218\ub97c \ud68c\ubcf5\uc2dc\ud0a8\ub2e4. Bulletin of Experimental Biology and Medicine, 163(4), 547\u2013550.<\/span>
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/28853087\/<\/a><\/span><\/p>\n

(6)<\/strong> Khavinson, V., Ilina, A., Kraskovskaya, N., Linkova, N., Kolchina, N., Mironova, E., Erofeev, A., & Petukhov, M. (2021). \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc\uc758 \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\u2014\ud6c4\uc131\uc720\uc804\ud559\uc801 \uc870\uc808\uc81c. Pharmaceuticals, 14(6), 515.<\/span>
\uc800\ub110 \ub9c1\ud06c: https:\/\/www.mdpi.com\/1424-8247\/14\/6\/515<\/a><\/span><\/p>","protected":false},"excerpt":{"rendered":"

\ud30c\uc778\uc54c\ub860\uc740 \uc0dd\uccb4 \uc870\uc808 \ud3a9\ud0c0\uc774\ub4dc\ub85c, \uc2e4\ud5d8 \uc5f0\uad6c\uc5d0\uc11c \uc2e0\uacbd \uc138\ud3ec \ubcf4\ud638, \uc138\ud3ec \uacfc\uc815 \uc870\uc808 \ubc0f \uac74\uac15\ud55c \ub178\ud654 \uc9c0\uc6d0\uc5d0 \ub300\ud55c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\ubc29\uba74\uc5d0 \uac78\uce5c \uc791\uc6a9 \uae30\uc804\uc73c\ub85c \uc778\ud574\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[253],"tags":[],"class_list":["post-49667","post","type-post","status-publish","format-standard","hentry","category-kategoria-pinealon","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/posts\/49667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/comments?post=49667"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/posts\/49667\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/media?parent=49667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/categories?post=49667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/ko\/wp-json\/wp\/v2\/tags?post=49667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}