{"id":46052,"date":"2026-04-22T16:53:48","date_gmt":"2026-04-22T14:53:48","guid":{"rendered":"https:\/\/semaxpolska.com\/?p=46052"},"modified":"2026-04-16T17:02:29","modified_gmt":"2026-04-16T15:02:29","slug":"kadas-ghk-cu-vara-peptidu-devas-tika-lietotas-dzivnieku-un-cilveku-petijumos","status":"publish","type":"post","link":"https:\/\/bioevidencehub.com\/lv\/jakie-dawki-peptydu-miedziowego-ghk-cu-byly-stosowane-w-badaniach-na-zwierzetach-i-u-ludzi\/","title":{"rendered":"K\u0101das vara pept\u012bdu (GHK-Cu) devas tika lietotas p\u0113t\u012bjumos ar dz\u012bvniekiem un cilv\u0113kiem?"},"content":{"rendered":"

Vara pept\u012bdu (GHK-Cu) devas dz\u012bvnieku un cilv\u0113ku p\u0113t\u012bjumos<\/h2>\n

P\u0113t\u012bjumos izmantot\u0101s vara pept\u012bda devas iev\u0113rojami at\u0161\u0137iras atkar\u012bb\u0101 no p\u0113t\u012bjuma mode\u013ca un ievad\u012b\u0161anas veida. P\u0113t\u012bjumos ar dz\u012bvniekiem parasti izmanto no mikrogramiem l\u012bdz miligramiem uz kilogramu \u0137erme\u0146a svara, savuk\u0101rt p\u0113t\u012bjumos ar cilv\u0113kiem p\u0101rsvar\u0101 izmanto lok\u0101lu lieto\u0161anu vai nelielu sist\u0113misku iedarb\u012bbu, nevis prec\u012bzi noteiktas iek\u0161\u0113j\u0101s devas. P\u0113t\u012bjumos ar dz\u012bvniekiem vara pept\u012bdu ievad\u012bja, cita starp\u0101 injic\u0113jot intraperitone\u0101li, lietojot lok\u0101li vai izmantojot biomateri\u0101lus. Eksperiment\u0101l\u0101s devas, par kur\u0101m zi\u0146ots, visbie\u017e\u0101k sv\u0101rst\u0101s no aptuveni 0,5 mg\/kg l\u012bdz 10 mg\/kg vair\u0101kos ievad\u012b\u0161anas re\u017e\u012bmos. Da\u017eos meh\u0101nistiskajos p\u0113t\u012bjumos tiek l\u0113sta ar\u012b 100-200 mg kop\u0113ja dienas ekspoz\u012bcija uz visu \u0137ermeni (Pickart et al., 2014). Lok\u0101lajos p\u0113t\u012bjumos ar dz\u012bvniekiem vara pept\u012bdu parasti lieto zem\u0101s koncentr\u0101cij\u0101s prepar\u0101tos, kas iedarbojas lok\u0101li, nevis sist\u0113miski. \u0160\u0101da pieeja ir izplat\u012bta br\u016b\u010du un apdegumu mode\u013cos, kur pept\u012bdu pieg\u0101d\u0101 ar t\u0101du sist\u0113mu pal\u012bdz\u012bbu k\u0101 liposomas, hidrog\u0113li vai skeoldi, lai veicin\u0101tu audu re\u0123ener\u0101ciju (Wang et al., 2017; Zhou et al., 2021).<\/p>\n

Cilv\u0113ku p\u0113t\u012bjumos deva ir maz\u0101k standartiz\u0113ta un visbie\u017e\u0101k attiecas uz lok\u0101lu vai kosm\u0113tisku lieto\u0161anu. Kl\u012bniskajos p\u0113t\u012bjumos par br\u016b\u010du dz\u012b\u0161anu, piem\u0113ram, diab\u0113tisk\u0101m \u010d\u016bl\u0101m, vara pept\u012bds tika uzkl\u0101ts tie\u0161i uz skartaj\u0101m viet\u0101m, nevis lietots visp\u0101r\u012bgi. T\u0101p\u0113c ir gr\u016bti tie\u0161i sal\u012bdzin\u0101t devas starp p\u0113t\u012bjumiem (Mulder et al., 1994). Jaun\u0101k\u0101s pieg\u0101des metod\u0113s, piem\u0113ram, mikroadat\u0101s vai intraderm\u0101l\u0101s sist\u0113m\u0101s, ir pier\u0101d\u012bts, ka vara pept\u012bds organism\u0101 tiek relat\u012bvi \u0101tri izvad\u012bts, kas noz\u012bm\u0113, ka, lai saglab\u0101tu efektu, ir nepiecie\u0161ama atk\u0101rtota lieto\u0161ana vai kontrol\u0113ta atbr\u012bvo\u0161anas sist\u0113mas (Li et al., 2015). Deguna un injekciju lieto\u0161ana galvenok\u0101rt tika p\u0113t\u012bta prekl\u012bniskos mode\u013cos, \u012bpa\u0161i neirolo\u0123iskos, ta\u010du tr\u016bkst standartiz\u0113tu devu sh\u0113mu cilv\u0113kiem, lietojot \u0161\u012bs metodes.<\/p>\n

No meh\u0101nisk\u0101 viedok\u013ca devu main\u012bgums rodas no t\u0101, k\u0101 vara pept\u012bds darbojas organism\u0101. Tas tiek \u0101tri metaboliz\u0113ts, sp\u0113c\u012bgi saista varu un darbojas galvenok\u0101rt lok\u0101li audos, nevis prasa augstu koncentr\u0101ciju asin\u012bs. T\u0101p\u0113c efektivit\u0101te bie\u017ei tiek sasniegta lieto\u0161anas viet\u0101, nevis ar augst\u0101m sist\u0113misk\u0101m dev\u0101m. P\u0113t\u012bjumos lietotais vara pept\u012bds ir pieejams no t\u0101diem pieg\u0101d\u0101t\u0101jiem k\u0101 SemaxPolska. J\u0101uzsver, ka dz\u012bvnieku p\u0113t\u012bjumos un eksperimentos izmantot\u0101s devas nav dro\u0161\u012bbas vai efektivit\u0101tes vadl\u012bnijas cilv\u0113kiem, jo v\u0113l nav noteikta standarta kl\u012bnisk\u0101 doz\u0113\u0161ana.<\/p>\n

K\u0101das vara pept\u012bdu koncentr\u0101cijas tika izmantotas kosm\u0113tikas p\u0113t\u012bjumos?<\/strong><\/h2>\n

Kosm\u0113tiskajos un dermatolo\u0123iskajos p\u0113t\u012bjumos vara pept\u012bds parasti tiek lietots zemos koncentr\u0101cij\u0101s lok\u0101li lietojamos prepar\u0101tos. Visbie\u017e\u0101k tie sv\u0101rst\u0101s no aptuveni 0,01%l\u012bdz 0,1%, lai gan da\u017eos formul\u0113jumos vai p\u0113tnieciskos projektos ir izmantotas koncentr\u0101cijas, kas tuvojas 0,4%. Kontrol\u0113tos cilv\u0113ku p\u0113t\u012bjumos, kas v\u0113rsti uz \u0101das noveco\u0161anos un atjauno\u0161anu, \u0161ie prepar\u0101ti parasti tika lietoti divas reizes dien\u0101 8 l\u012bdz 12 ned\u0113\u013cu period\u0101. \u0160ie p\u0113t\u012bjumi par\u0101d\u012bja \u0101das biezuma, elast\u012bbas uzlabo\u0161anos un grumbu redzam\u012bbas samazin\u0101\u0161anos (Pickart & Margolina, 2018; Badenhorst et al., 2016). Kontrol\u0113tos p\u0113t\u012bjumos vara pept\u012bda lieto\u0161ana nodro\u0161in\u0101ja izm\u0113r\u0101mu \u0101das kvalit\u0101tes uzlabo\u0161anos bez iev\u0113rojamas sist\u0113misk\u0101s absorbcijas, kas apstiprina t\u0101 lok\u0101lo iedarb\u012bbu.<\/p>\n

Iepriek\u0161\u0113jie p\u0113t\u012bjumi ar\u012b par\u0101d\u012bju\u0161i, ka pat zemas vara pept\u012bdu koncentr\u0101cijas var stimul\u0113t \u0101das atjauno\u0161anos. Tas notiek, jo vara pept\u012bds darbojas k\u0101 sign\u0101lmolekula, inici\u0113jot biolo\u0123iskos procesus, nevis izr\u0101dot vienk\u0101r\u0161u devas un efekta attiec\u012bbu, kas rakstur\u012bga daudz\u0101m viel\u0101m (Reddy et al., 2012). P\u0113t\u012bjumi par \u0101das iespie\u0161anos liecina, ka vara pept\u012bds var iziet cauri epidermas ragu sl\u0101nim un sasniegt dzi\u013c\u0101kus sl\u0101\u0146us, kur tas ietekm\u0113 atjauno\u0161an\u0101s procesus pat zem\u0101s koncentr\u0101cij\u0101s (Hostynek et al., 2010).<\/p>\n

No meh\u0101nistisk\u0101 viedok\u013ca zem\u0101kas koncentr\u0101cijas ir efekt\u012bvas, jo vara pept\u012bds regul\u0113 g\u0113nu aktivit\u0101ti, atbalsta kolag\u0113na ra\u017eo\u0161anu un ietekm\u0113 antioksidat\u012bvos ce\u013cus, nevis prasa augstu sist\u0113misku iedarb\u012bbu. Tom\u0113r j\u0101\u0146em v\u0113r\u0101, ka at\u0161\u0137ir\u012bbas formul\u0101cij\u0101s, pieg\u0101des sist\u0113m\u0101s un p\u0113t\u012bjumu dizainos var ietekm\u0113t rezult\u0101tus, padarot to tie\u0161u sal\u012bdzin\u0101\u0161anu gr\u016btu. Vara pept\u012bds, ko izmanto p\u0113t\u012bjumos un farm\u0101cij\u0101, ir pieejams no pieg\u0101d\u0101t\u0101jiem, piem\u0113ram, SemaxPolska. Kosm\u0113tikas p\u0113t\u012bjumos izmantot\u0101s koncentr\u0101cijas nedr\u012bkst uzskat\u012bt par medic\u012bnisko devu ekvivalentiem, un prezent\u0113tie rezult\u0101ti nav apstiprin\u0101ti terapeitiski efekti.<\/p>\n

Atsauces<\/h4>\n
    \n
  • Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014). GHK un DNS: Cilv\u0113ka genoma atiestat\u012b\u0161ana uz vesel\u012bbu. BioMed Research International, 2014<\/em>, 151479.<\/span><\/li>\n
  • Wang, X., Liu, B., Xu, Q., Sun, H., Shi, M., & Zhang, L. (2017). GHK-Cu-liposomas pa\u0101trina apdeguma br\u016b\u010du dz\u012b\u0161anu pel\u0113m, veicinot \u0161\u016bnu prolifer\u0101ciju un angiogen\u0113zi. Br\u016b\u010du dz\u012b\u0161ana un re\u0123ener\u0101cija, 25<\/em>(2), 280\u2013287.<\/span><\/li>\n
  • Zhou, M., Wu, X., Luo, J., Yang, G., Lu, Y., Lin, S., & Li, Y. (2021). Vara pept\u012bdu saturo\u0161i 3D druk\u0101ti uz z\u012bda balst\u012bti skafoldi veicina vaskulariz\u0113tu kaulu re\u0123ener\u0101ciju. \u0136\u012bmijas in\u017eenierijas \u017eurn\u0101ls, 417<\/em>, 129327.<\/span><\/li>\n
  • Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Diab\u0113ta slimnieku \u010d\u016blu dz\u012b\u0161anas uzlabo\u0161ana, lok\u0101li apstr\u0101d\u0101jot ar glicil-L-histidil-L-lic\u012bna vara. Br\u016b\u010du dz\u012b\u0161ana un atjauno\u0161an\u0101s, 2<\/em>(4), 259\u2013269.<\/span><\/li>\n
  • Li, H., Low, Y. S. J., Chong, H. P., Zin, M. T., Lee, C. Y., & Li, B. (2015). Vara pept\u012bdu pieg\u0101de caur \u0101du ar mikroadatu pal\u012bdz\u012bbu: izaicin\u0101jumi un strat\u0113\u0123ijas derm\u0101lai pieg\u0101dei. Farm\u0101cijas izmekl\u0113\u0161anas \u017eurn\u0101ls, 45<\/em>(6), 633\u2013642.<\/span><\/li>\n
  • Pickart, L., & Margolina, A. (2018). GHK-Cu pept\u012bda re\u0123enerat\u012bv\u0101s un aizsarg\u0101jo\u0161\u0101s darb\u012bbas jaun\u0101ko g\u0113nu datu gaism\u0101. International Journal of Molecular Sciences, 19<\/em>(7), 1987.<\/span><\/li>\n
  • Badenhorst, T., Svirskis, D., Merrilees, M., & Bolke, L. (2016). GHK-Cu ietekme uz MMP un TIMP ekspresiju, kolag\u0113na un elast\u012bna ra\u017eo\u0161anu un sejas grumbu parametriem. Gerontolo\u0123ijas zin\u0101tnes \u017eurn\u0101ls, 4<\/em>(2), 1\u20138.<\/span><\/li>\n
  • Reddy, B. Y., Jow, T., & Hantash, B. M. (2012). Bioakt\u012bvie oligopept\u012bdi dermatolo\u0123ij\u0101: I da\u013ca. Eksperiment\u0101l\u0101 dermatolo\u0123ija, 21<\/em>(8), 563\u2013568.<\/span><\/li>\n
  • Hostynek, J. J., Dreher, F., & Maibach, H. I. (2010). Cilv\u0113ka \u0101das vara tripept\u012bda in vitro notur\u0113\u0161ana un iespie\u0161an\u0101s atkar\u012bb\u0101 no \u0101das sl\u0101\u0146a. Inflammation Research, 59<\/em>(12), 1051\u20131059.<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    Varas pept\u012bda (GHK-Cu) devas p\u0113t\u012bjumos ar dz\u012bvniekiem un cilv\u0113kiem Varas pept\u012bda devas, ko izmanto zin\u0101tniskajos p\u0113t\u012bjumos, iev\u0113rojami at\u0161\u0137iras atkar\u012bb\u0101 no p\u0113t\u012bjuma mode\u013ca\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[93],"tags":[],"class_list":["post-46052","post","type-post","status-publish","format-standard","hentry","category-kategoria-ghk-cu","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts\/46052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/comments?post=46052"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts\/46052\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/media?parent=46052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/categories?post=46052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/tags?post=46052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}