Zin\u0101tnisk\u0101 interese par Pinealonu ir pieaugusi, \u0146emot v\u0113r\u0101 t\u0101 potenci\u0101l\u0101s neiroprotekt\u012bv\u0101s \u012bpa\u0161\u012bbas eksperiment\u0101los Alcheimera slim\u012bbas mode\u013cos. Lai gan v\u0113l nav veikti lieli kl\u012bniskie p\u0113t\u012bjumi ar cilv\u0113kiem, kuros Pinealons b\u016btu nov\u0113rt\u0113ts k\u0101 Alcheimera slim\u012bbas terapija, vair\u0101ki prekl\u012bniskie p\u0113t\u012bjumi ir analiz\u0113ju\u0161i t\u0101 ietekmi uz neironu izdz\u012bvo\u0161anu, sinapsu integrit\u0101ti un ar neirode\u0123ener\u0101ciju saist\u012btajiem procesiem (1,2).<\/p>\n
Viens no noz\u012bm\u012bg\u0101kajiem p\u0113t\u012bjumiem tika veikts Kraskovskajas un kol\u0113\u0123u vad\u012bb\u0101, izmantojot in vitro modeli, kas atspogu\u013co amilo\u012bda izrais\u012btu sinaptotoksicit\u0101ti un atspogu\u013co da\u017eus neironu boj\u0101jumu aspektus, kas nov\u0113roti Alcheimera slim\u012bb\u0101 (1). P\u0113t\u012bjum\u0101 peles hipokampa prim\u0101rie neironi tika pak\u013cauti ar amilo\u012bdu saist\u012btai toksicit\u0101tei, kas parasti izraisa to nobriedu\u0161o dendr\u012btu atzaru skaita samazin\u0101\u0161anos, kuri piedal\u0101s neironu savstarp\u0113j\u0101 komunik\u0101cij\u0101. \u0100rst\u0113\u0161ana ar EDR pept\u012bdu (Pinealon) 200 ng\/ml koncentr\u0101cij\u0101 palielin\u0101ja s\u0113nveida dendr\u012btu atzaru skaitu par 71% un atjaunoja to skaitu l\u012bdz norm\u0101lam l\u012bmenim (1).<\/p>\n
S\u0113\u0146veida dendr\u012btiskie smaili\u0146i ir \u013coti stabilas sinaptisk\u0101s strukt\u016bras, kas sp\u0113l\u0113 galveno lomu m\u0101c\u012b\u0161an\u0101s, atmi\u0146as veido\u0161an\u0101s un ilgtermi\u0146a inform\u0101cijas uzglab\u0101\u0161anas procesos. \u0160o strukt\u016bru zudums bie\u017ei ir saist\u012bts ar kognit\u012bvo funkciju pasliktin\u0101\u0161anos un neirode\u0123enerat\u012bv\u0101m slim\u012bb\u0101m. Pinealona sp\u0113ja atjaunot dendr\u012btiskos smaili\u0146u bl\u012bvumu liecina, ka tas var pal\u012bdz\u0113t saglab\u0101t neironu savienojumus un atbalst\u012bt neiroplastiskumu neirode\u0123enerat\u012bva stresa apst\u0101k\u013cos (1).<\/p>\n
Papildu pier\u0101d\u012bjumus sniedza Khavinsona un kol\u0113\u0123u p\u0113t\u012bjumi, kuros tika nov\u0113rt\u0113ti \u012bsi bioregul\u0113jo\u0161i pept\u012bdi Alcheimera slim\u012bbas peles model\u012b (2). Rezult\u0101ti par\u0101d\u012bja neiroprotekt\u012bvu iedarb\u012bbu, kas saist\u012bta ar palielin\u0101tu neironu rezistenci un aizsardz\u012bbu pret ar vecumu saist\u012bt\u0101m neirode\u0123enerat\u012bv\u0101m izmai\u0146\u0101m. Pinealons tika klasific\u0113ts k\u0101 epi\u0123en\u0113tisko pept\u012bdu grupa, kas sp\u0113j regul\u0113t \u0161\u016bnu aktivit\u0101ti un veicin\u0101t neironu izdz\u012bvo\u0161anu eksperiment\u0101los apst\u0101k\u013cos (2).<\/p>\n
Nov\u0113rot\u0101s sekas var izrais\u012bt vair\u0101ki biolo\u0123iski meh\u0101nismi. Laboratorijas p\u0113t\u012bjumi liecina, ka Pinealons var samazin\u0101t oksidat\u012bvo stresu, ierobe\u017eot \u0161\u016bnu boj\u0101jumus, ietekm\u0113t g\u0113nu ekspresiju un atbalst\u012bt neironu dz\u012bvotsp\u0113ju (2-4). \u0160ie kop\u012bgie darb\u012bbas var pal\u012bdz\u0113t saglab\u0101t sinaptisk\u0101s strukt\u016bras un ierobe\u017eot da\u017eus ar neirode\u0123ener\u0101ciju saist\u012btus stresa faktorus.<\/p>\n
Lai gan \u0161ie rezult\u0101ti ir daudzsolo\u0161s, pa\u0161reiz\u0113jie pier\u0101d\u012bjumi galvenok\u0101rt n\u0101k no \u0161\u016bnu un dz\u012bvnieku p\u0113t\u012bjumiem. L\u012bdz \u0161im nav public\u0113ti lieli kl\u012bniskie p\u0113t\u012bjumi, kas nov\u0113rt\u0113tu Pinealon Alcheimera slim\u012bbas \u0101rst\u0113\u0161an\u0101. T\u0101p\u0113c Pinealon pa\u0161laik vajadz\u0113tu uzskat\u012bt par eksperiment\u0101lu neiroprotekt\u012bvu pept\u012bdu, kam nepiecie\u0161ami turpm\u0101ki p\u0113t\u012bjumi, nevis par atz\u012btu Alcheimera slim\u012bbas \u0101rst\u0113\u0161anas metodi.<\/p>\n
Krievu literat\u016br\u0101 par bioregul\u0113jo\u0161ajiem pept\u012bdiem Pinealon bie\u017ei tiek klasific\u0113ts k\u0101 geroprotektors. \u0160is termins attiecas uz savienojumiem, kas var atbalst\u012bt vesel\u012bgu noveco\u0161anos, fiziolo\u0123isko funkciju saglab\u0101\u0161anu un potenci\u0101li pal\u0113nin\u0101t da\u017eus biolo\u0123isk\u0101s noveco\u0161anas aspektus. Liela da\u013ca \u0161o p\u0113t\u012bjumu n\u0101k no Vladimira Havinsona un vi\u0146a kol\u0113\u0123u darbiem, kuri pla\u0161i analiz\u0113ja \u012bsus regul\u0113jo\u0161os pept\u012bdus attiec\u012bb\u0101 uz to potenci\u0101lo lomu ilgm\u016b\u017e\u012bb\u0101 un vesel\u012bbas uztur\u0113\u0161an\u0101 vecumdien\u0101s (5).<\/p>\n
Viens no noz\u012bm\u012bg\u0101kajiem p\u0113t\u012bjumiem par Pinealon un vesel\u012bgu noveco\u0161anu ir veikts Meshchaninovam un kol\u0113\u0123iem, p\u0113tot personas vecum\u0101 no 41 l\u012bdz 83 gadiem ar hronisku polimorbidit\u0101ti un remisij\u0101 eso\u0161u organisko smadze\u0146u sindromu (5). P\u0113tnieki nov\u0113rt\u0113ja Pinealon un cita biore\u0123enerat\u012bva pept\u012bda, Vesugen, ietekmi uz biomar\u0137ieriem, kas saist\u012bti ar biolo\u0123isko vecumu un organisma funkcion\u0101lo st\u0101vokli.<\/p>\n
Zin\u0101tnieki atz\u012bm\u0113ja, ka Pinealons rad\u012bja noz\u012bm\u012bgus anaboliskus efektus, k\u0101 ar\u012b uzlaboja centr\u0101l\u0101s nervu sist\u0113mas un citu svar\u012bgu org\u0101nu funkcion\u0101lo aktivit\u0101ti (5). \u0160\u012bs izmai\u0146as tika saist\u012btas ar l\u0113n\u0101ku biolo\u0123isk\u0101s noveco\u0161an\u0101s gaitu, ko nov\u0113rt\u0113ja, pamatojoties uz analiz\u0113tajiem bio mar\u0137ieriem. Autori secin\u0101ja, ka Pinealons piem\u012bt gan geroprotekt\u012bvas, gan neiroprotekt\u012bvas \u012bpa\u0161\u012bbas, kas var atbalst\u012bt vesel\u012bgu noveco\u0161anos person\u0101m, kur\u0101m ir ar vecumu saist\u012bti funkcion\u0101li trauc\u0113jumi.<\/p>\n
P\u0113t\u012bjums ar\u012b liecin\u0101ja, ka Pinealons var\u0113tu ietekm\u0113t metaboliskos un \u0161\u016bnu ce\u013cus, kas iesaist\u012bti noveco\u0161anas proces\u0101. Lai gan \u0101rst\u0113\u0161anas laik\u0101 tika nov\u0113rota vair\u0101ku noveco\u0161an\u0101s bioz\u012bmju uzlabo\u0161an\u0101s, pept\u012bds neietekm\u0113ja hromat\u012bna kondens\u0101ciju, kas nor\u0101d\u012bja uz neatkl\u0101tu nelabv\u0113l\u012bgu ietekmi uz \u0123en\u0113tisk\u0101 materi\u0101la stabilit\u0101ti eksperiment\u0101lajos apst\u0101k\u013cos (5). P\u0113tnieki to uzskat\u012bja par b\u016btisku dro\u0161\u012bbas r\u0101d\u012bt\u0101ju un ieteica veikt turpm\u0101kus p\u0113t\u012bjumus.<\/p>\n
Da\u017ei laboratorijas p\u0113t\u012bjumi sniedz potenci\u0101lus meh\u0101nistiskus \u0161o nov\u0113rojumu skaidrojumus. Tika par\u0101d\u012bts, ka Pinealon samazina oksidat\u012bvo stresu, atbalsta neironu izdz\u012bvo\u0161anu, regul\u0113 ar seroton\u012bnu saist\u012bt\u0101s signaliz\u0101cijas ce\u013cus un ietekm\u0113 g\u0113nu ekspresiju, izmantojot epigene\u021biskus meh\u0101nismus (2\u20134,6). T\u0101 k\u0101 oksidat\u012bvais stress un trauc\u0113ta \u0161\u016bnu regul\u0101cija tiek uzskat\u012bti par faktoriem, kas veicina biolo\u0123isko noveco\u0161anos, \u0161\u012bs darb\u012bbas var da\u013c\u0113ji izskaidrot Pinealon nov\u0113rot\u0101s geroprotekt\u012bv\u0101s \u012bpa\u0161\u012bbas.<\/p>\n
Neskatoties uz daudzsolo\u0161ajiem rezult\u0101tiem, p\u0113t\u012bjumi par Pinealon un noveco\u0161an\u0101s procesiem joproj\u0101m ir sal\u012bdzino\u0161i ierobe\u017eoti, sal\u012bdzinot ar pamat\u012bg\u0101k izp\u0113t\u012btaj\u0101m ar ilgm\u016b\u017e\u012bbu saist\u012btaj\u0101m intervenc\u0113m. Nepiecie\u0161ami papildu kl\u012bniskie p\u0113t\u012bjumi, lai noteiktu, vai biolo\u0123isk\u0101 vecuma biomarkeru uzlabo\u0161an\u0101s tie\u0161\u0101m rada b\u016btisku ilgtermi\u0146a ieguvumu vesel\u012bbai. Tom\u0113r pieejamie dati pozicion\u0113 Pinealon k\u0101 vienu no lab\u0101k izp\u0113t\u012btajiem bioregul\u0113jo\u0161iem pept\u012bdiem vesel\u012bgas noveco\u0161an\u0101s un neirogerontolo\u0123ijas jom\u0101.<\/p>\n
Miegs ir viens no visbie\u017e\u0101k apspriestajiem tematiem cilv\u0113ku vid\u016b, kuri interes\u0113jas par Pinealon. P\u0113d\u0113jos gados iev\u0113rojami palielin\u0101jusies interese par t\u0101d\u0101m fr\u0101z\u0113m k\u0101 \u201ePinealon un miegs\u201d, \u201ePinealon miegam\u201d, \u201ePinealon peptide sleep\u201d, \u201ePinealon REM sleep\u201d un \u201ePinealon circadian rhythm\u201d. Tom\u0113r, izv\u0113rt\u0113jot \u0161os apgalvojumus, ir svar\u012bgi at\u0161\u0137irt zin\u0101tniskus pier\u0101d\u012bjumus no anekdotiskiem nov\u0113rojumiem.<\/p>\n
Pa\u0161reiz neviens kontrol\u0113ts kl\u012bniskais p\u0113t\u012bjums nav pier\u0101d\u012bjis, ka Pinealon uzlabo miega kvalit\u0101ti, palielina REM miega f\u0101zi, regul\u0113 diennakts ritmu vai \u0101rst\u0113 miega trauc\u0113jumus. Pieejam\u0101 zin\u0101tnisk\u0101 literat\u016bra galvenok\u0101rt koncentr\u0113jas uz neiroprotekciju, oksidat\u012bv\u0101 stresa regul\u0101ciju, kognit\u012bvaj\u0101m funkcij\u0101m, seroton\u012bna ekspresiju un vesel\u012bgu noveco\u0161anos, nevis uz ar miegu saist\u012btiem rezult\u0101tiem (2\u20136).<\/p>\n
Viens no iesp\u0113jamiem Pinealon interesam un miegam izskaidrot ir p\u0113t\u012bjumi, kas par\u0101da, ka pept\u012bds stimul\u0113 g\u0113na ekspresiju, kas kod\u0113 triptof\u0101na hidroksil\u0101zi \u2013 \u0101trumu ierobe\u017eojo\u0161u enz\u012bmu seroton\u012bna sint\u0113z\u0113 (6). Seroton\u012bns ir melaton\u012bna priek\u0161stats un tam ir fundament\u0101la noz\u012bme miega un nomoda cikla, garast\u0101vok\u013ca un neirolo\u0123isko funkciju regul\u0113\u0161an\u0101. P\u0113tnieki liek dom\u0101t, ka Pinealon sp\u0113ja ietekm\u0113t ar seroton\u012bnu saist\u012btos ce\u013cus var veicin\u0101t t\u0101 neiroprotekt\u012bvo un geroprotekt\u012bvo aktivit\u0101ti (6).<\/p>\n
T\u0101 k\u0101 seroton\u012bns ir cie\u0161i saist\u012bts ar miega regul\u0113\u0161anu, da\u017ei p\u0113tnieki izvirz\u012bju\u0161i hipot\u0113zi, ka Pinealons var\u0113tu netie\u0161i ietekm\u0113t ar miegu saist\u012btus procesus. Tom\u0113r pa\u0161laik tr\u016bkst tie\u0161u kl\u012bnisku pier\u0101d\u012bjumu, kas apstiprin\u0101tu miega kvalit\u0101tes, miega ilguma, REM miega f\u0101zes vai diennakts ritma regul\u0101cijas uzlabo\u0161anos.<\/p>\n
Tie\u0161saistes kopienu zi\u0146ojumi un tie\u0161saistes diskusijas sniedz papildu inform\u0101ciju, kas izskaidro Pinealon interesi \u0161aj\u0101 jom\u0101. Anekdotiskos aprakstos da\u017ei cilv\u0113ki zi\u0146o par subjekt\u012bvu miega kvalit\u0101tes uzlabo\u0161anos, lab\u0101ku sap\u0146u atcer\u0113\u0161anos, intens\u012bv\u0101kiem sap\u0146iem un liel\u0101ku atp\u016btu p\u0113c pamo\u0161an\u0101s. Citi apgalvo, ka pirms gul\u0113tie\u0161anas lietoju\u0161i deguna aerosols Pinealon, jo vi\u0146i izj\u016bt miega un sap\u0146u ieguvumus.<\/p>\n
J\u0101uzsver, ka \u0161ie nov\u0113rojumi ir anekdotiski un nav apstiprin\u0101ti kontrol\u0113tos kl\u012bniskos p\u0113t\u012bjumos. Lietot\u0101ju pieredzi var ietekm\u0113t daudzi faktori, tostarp cer\u012bbas, izmantotie doz\u0113\u0161anas protokoli, individu\u0101l\u0101 neiro\u0137\u012bmija, vienlaikus lietotie uztura bag\u0101tin\u0101t\u0101ji un placebo efekts.<\/p>\n
T\u0101 k\u0101 kl\u012bnisko datu ir maz, pa\u0161laik nav iesp\u0113jams izstr\u0101d\u0101t uz pier\u0101d\u012bjumiem balst\u012btas vadl\u012bnijas par optim\u0101lu Pinealon lieto\u0161anas laiku miega ietekm\u0113\u0161anai. Turpm\u0101kie p\u0113t\u012bjumi par miega kvalit\u0101ti, REM miega f\u0101zi, diennakts ritmu biolo\u0123iju un neirotransmitera regul\u0101ciju var\u0113tu pal\u012bdz\u0113t noskaidrot, vai Pinealon b\u016btiski ietekm\u0113 ar miegu saist\u012btus parametrus.<\/p>\n
Kopum\u0101 pa\u0161reiz\u0113jie zin\u0101tniskie pier\u0101d\u012bjumi apstiprina Pinealon lomu neironu regul\u0101cij\u0101 un ar seroton\u012bnu saist\u012btajos ce\u013cos, savuk\u0101rt apgalvojumi par miega ieguvumiem paliek provizoriski un galvenok\u0101rt balst\u0101s uz anekdotiskiem nov\u0113rojumiem, nevis uz stingriem kl\u012bniskiem pier\u0101d\u012bjumiem.<\/p>\n
Saturs ir paredz\u0113ts tikai izgl\u012btojo\u0161iem un informat\u012bviem nol\u016bkiem, un to nedr\u012bkst interpret\u0113t k\u0101 medic\u012bnisku padomu, diagnozi, \u0101rst\u0113\u0161anu vai profesion\u0101lu ieteikumu. Pinealon nav apstiprin\u0101jis ASV P\u0101rtikas un z\u0101\u013cu p\u0101rvalde (FDA), Eiropas Z\u0101\u013cu a\u0123ent\u016bra (EMA) vai vairums citu regulat\u012bvo iest\u0101\u017eu Alcheimera slim\u012bbas, miega trauc\u0113jumu, ar noveco\u0161anos saist\u012btu slim\u012bbu vai jebk\u0101du citu medic\u012bnisku indik\u0101ciju \u0101rst\u0113\u0161anai. Liel\u0101k\u0101 da\u013ca pieejamo datu n\u0101k no prekl\u012bniskiem p\u0113t\u012bjumiem, dz\u012bvnieku mode\u013ciem un ierobe\u017eota skaita cilv\u0113ku p\u0113t\u012bjumu. Nepiecie\u0161ami turpm\u0101ki, labi izstr\u0101d\u0101ti kl\u012bniskie p\u0113t\u012bjumi, lai lab\u0101k noteiktu Pinealon efektivit\u0101ti, dro\u0161\u012bbu un ilgtermi\u0146a ietekmi da\u017e\u0101d\u0101s popul\u0101cij\u0101s.<\/p>\n
(1)<\/strong> Kraskovska, N. A., Kukanova, E. O., Linkova, N. S., Popugaeva, E. A., & Havinsona, V. K. (2017). Trpept\u012bdi atjauno neironu smaili\u0146u skaitu in vitro model\u0113t\u0101s Alcheimera slim\u012bbas apst\u0101k\u013cos<\/em>. Biolo\u0123ijas un medic\u012bnas eksperimentu bi\u013cetens, 163<\/em>(4), 547\u2013550. https:\/\/doi.org\/10.1007\/s10517-017-3847-2<\/a><\/span> (2)<\/strong> Khavinsona, V., I\u013cina, A., Kraskovska, N., Linkova, N., Kol\u010dina, N., Mironova, E., Jerofejevs, A., & Petuhovs, M. (2021). Neiroprotekt\u012bv\u0101 ietekme tripept\u012bdiem \u2014 epigen\u0113tiskiem regulatoriem Alcheimera slim\u012bbas peles model\u012b<\/em>. Farmaceitikas, 14<\/em>(6), 515. https:\/\/doi.org\/10.3390\/ph14060515<\/a><\/span> (3)<\/strong> Khavinson, V., Ribakova, Y., Trofimova, S. un citi. (2011). Pinealon palielina \u0161\u016bnu dz\u012bvotsp\u0113ju, nom\u0101cot br\u012bvo radik\u0101\u013cu l\u012bmeni un aktiviz\u0113jot proliferat\u012bvus procesus<\/em>. Atjauno\u0161an\u0101s p\u0113t\u012bjumu, 14<\/em>(5), 517\u2013523. https:\/\/doi.org\/10.1089\/rej.2011.1172<\/a><\/span> (4)<\/strong> Fedorejeva, L. I., Kirejevs, I. I., Khavinsons, V. K., un Vanju\u0161ins, B. F. (2011). \u012asi fluoresc\u0113jo\u0161i iez\u012bm\u0113ti pept\u012bdu iek\u013c\u016b\u0161ana kodol\u0101 HeLa \u0161\u016bn\u0101s un pept\u012bdu specifiska mijiedarb\u012bba in vitro ar deoksiribooligonucleot\u012bdiem un DNS<\/em>. Bio\u0137\u012bmija (Maskava), 76<\/em>(11), 1210\u20131219. https:\/\/doi.org\/10.1134\/S0006297911110022<\/a><\/span> (5)<\/strong> Me\u0161\u010daninovs, V. N., Tka\u010denko, E. L., \u017darkovs, S. V., Gavrilovs, I. V., & Katireva, J. E. (2015). Sint\u0113tisko pept\u012bdu ietekme uz pacientu ar hronisku polimorbidit\u0101ti un centr\u0101l\u0101s nervu sist\u0113mas organisko smadze\u0146u sindromu remonta laik\u0101 noveco\u0161anos<\/em>. Gerontolo\u0123ijas sasniegumi, 28<\/em>(1), 62\u201367.<\/span> (6)<\/strong> Khavinsons, V. K., Lin'kova, N. S., Tarnovska, S. I., Umnovs, R. S., Ela\u0161kina, E. V., & Durnova, A. O. (2014). \u012asi pept\u012bdi stimul\u0113 seroton\u012bna ekspresiju smadze\u0146u garozas \u0161\u016bn\u0101s<\/em>. Biolo\u0123ijas un medic\u012bnas eksperimentu bi\u013cetins, 157<\/em>(1), 77\u201380. https:\/\/doi.org\/10.1007\/s10517-014-2496-y<\/a><\/span> P\u0113t\u012bjumi par Pinealonu un Alcheimera slim\u012bbu Zin\u0101tnisk\u0101 interese par Pinealonu ir pieaugusi t\u0101 potenci\u0101lo neiroprotekt\u012bvo \u012bpa\u0161\u012bbu d\u0113\u013c Alcheimera slim\u012bbas eksperiment\u0101lajos mode\u013cos. Lai gan l\u012bdz \u0161im nav veikti\u2026<\/p>","protected":false},"author":7908,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[253],"tags":[],"class_list":["post-51175","post","type-post","status-publish","format-standard","hentry","category-kategoria-pinealon","beh-no-thumb"],"_links":{"self":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts\/51175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/users\/7908"}],"replies":[{"embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/comments?post=51175"}],"version-history":[{"count":0,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/posts\/51175\/revisions"}],"wp:attachment":[{"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/media?parent=51175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/categories?post=51175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioevidencehub.com\/lv\/wp-json\/wp\/v2\/tags?post=51175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/28853087\/<\/a><\/span><\/p>\n
\u017durn\u0101la saite: https:\/\/www.mdpi.com\/1424-8247\/14\/6\/515<\/a><\/span><\/p>\n
\u017durn\u0101la saite: https:\/\/journals.sagepub.com\/doi\/abs\/10.1089\/rej.2011.1172<\/a><\/span><\/p>\n
\u017durn\u0101la saite: https:\/\/link.springer.com\/article\/10.1134\/S0006297911110022<\/a><\/span><\/p>\n
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/26390612\/<\/a><\/span><\/p>\n
PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/24909721\/<\/a><\/span><\/p>","protected":false},"excerpt":{"rendered":"