Solcoseryl is a unique medical product derived from protein-free haemodialysate of dairy calves. It is enriched with components commonly found in cells and blood serum. Its main purpose is to increase the delivery of oxygen and glucose to cells, especially when they are oxygen deficient. Through this action, solcoseryl promotes cellular energetics, supporting the body's natural regeneration processes. Additionally, it plays a key role in skin rejuvenation and maintaining the integrity of blood vessels.
The solcoseryl preparation is available in various forms, such as an injectable liquid, gel or cream. There is also a special version for oral problems such as painful gums or lips. People reach for this medicine to alleviate various skin problems and for oral care.
Benefits of solcoseryl: Based on medical studies
Solcoseryl has demonstrated efficacy in a variety of conditions - from accelerating wound healing and relieving gingival inflammation to optimising neurological function. How can solcoseryl be an innovative therapeutic agent in various medical fields?
Benefits of solcoseryl for the brain and nervous system
Solcoseryl has shown promising results in numerous scientific studies that have focused on its potential benefits for brain and nervous system health. These range from reducing brain damage caused by bleeding to enhancing learning and memory processes in animal models.
Reduced brain damage: Studies show that solcoseryl may be helpful for people experiencing bleeding in the brain caused by a blood vessel rupture, known as an aneurysm. In one study, 300 patients with arterial aneurysms received solcoseryl, while 50 received no treatment. The results showed that the group receiving solcoseryl showed better recovery. These patients achieved better outcomes 30 days after brain injury. They achieved fewer serious health problems and deaths compared to the group not receiving the drug. This suggests that solcoseryl may help mitigate the negative effects of bleeding in the brain caused by ruptured arteries [1].
Prevention of nerve ulcers: solcoseryl in combination with Proglumide can effectively prevent nerve ulcers in patients with significant renal problems. In a scientific study, patients with significant renal problems following surgery or trauma were given solcoseryl (in combination with Proglumide) as a means of preventing nerve ulcers. The results of the study showed that patients receiving this treatment were less likely to develop ulcers compared to the group that did not receive this drug combination [2].
Modulation of brain activity: an animal study suggests that solcoseryl positively affects brain activity. It was shown that, at specific times and doses, the administration of solcoseryl had an effect on the movements and sleep patterns of rats. For example: it reduced sleep time when given 15 minutes before another drug. These results suggest that solcoseryl may have the ability to modulate brain activity and influence specific behaviours [3].
Improving learning and memory: another study in rats indicates that solcoseryl may have a beneficial effect on learning and memory processes. Solcoseryl was found to improve both the 'acquisition' phase of new information and its subsequent recall. For certain tasks, different doses showed specific positive effects, suggesting the potential of solcoseryl to enhance brain function related to learning and memory [4].
Help with cerebral ischaemia: solcoseryl in combination with acupuncture may benefit cerebral ischaemia. An animal study showed that the combination of solcoseryl and acupuncture had better results in reducing symptoms than using each treatment separately. Specifically, this combined approach significantly reduced problems observed in the cerebral ischaemia model, such as high rates of neurological deficit and increased water and lactic acid content in the brain [5].
Potential benefits in treating blood circulation problems in the brain
Promising treatment for adverse cerebrovascular conditions
solcoseryl was studied in the context of its effect on patients with early or ongoing cerebrovascular problems, conditions related to blood circulation in the brain. Twenty-nine patients took part in the study. Some of them were struggling with vegetovascular dystonia, affecting the blood vessels and nervous system, and others with varying degrees of dyscratic encephalopathy, affecting brain function due to blood circulation problems. The results showed a positive effect of solcoseril. Patients experienced fewer and shorter episodes of vegetovascular problems and reported better general wellbeing. This suggests that solcoseryl may be a beneficial approach to managing conditions related to cerebral blood circulation [6, 6A].
Significant benefits for cerebrovascular insufficiency (CVI)
Cerebrovascular anaemia, known as CVI, is a condition in which there is a reduced blood supply to the brain. An extensive study was conducted. It involved 243 patients who received daily injections of solcoseryl (2.0 ml each) for 25 days, and this treatment was repeated twice a year. The results showed a marked reduction in neurological symptoms. Patients were also given medication to regulate blood pressure and prevent blood clots. The combination of solcoseryl with other drugs resulted in a significant reduction in the risk of patients worsening, as well as a reduction in the number of incidents of temporary blood supply disruptions and strokes compared to those treated with standard methods. These results suggest that solcoseryl may be an important component in the treatment of CVI, enhancing the benefits of other therapies and improving patients' overall health [7].
As such, solcoseryl can provide support for patients with cerebral blood circulation problems. Its benefits range from reducing symptoms, improving overall health and reducing the risk of more serious complications. These results highlight the potential of solcoseryl as an effective therapeutic agent for neurological problems.
Solcoseryl healing properties
Recent scientific research indicates that solcoseryl plays a significant role in accelerating and effectively supporting recovery from various types of injury.
Solcoseryl for eye health
Solcoseryl is gaining prominence in the field of ophthalmic care, offering a range of benefits for a variety of eye conditions. From dry eyes to corneal damage. The therapy is showing promising results in relieving symptoms and promoting healing. The following are scientific studies that illustrate the potential role of solcoseryl in ocular disorders.
Eye injury healing
Study of the efficacy of 'Solcoseryl Eye-Gel' compared to 'Cysteine Eye-Gel' for corneal injuries. Solcoseryl proved to be the more effective choice. After treatment with solcoseryl gel, its effect on tissue regeneration and increased cellular oxygen uptake was noted. Over the course of treatment, as many as 63% of patients using solcoseryl observed complete healing of their epithelial injuries, compared to only 53% for Cysteine Eye-Gel. This suggests that solcoseryl accelerates the recovery process after corneal injury and benefits ocular health [17].
Increased humidity and dry eye relief
A comparative study between 'solcoseryl eye drops' and 'Vitasic eye drops' showed that solcoseryl achieved better results. In participants with corneal erosion and dry eye syndrome, solcoseryl not only accelerated the healing process, but also increased eye moisture. The statistically significant improvement establishes the formulation as a more effective treatment option for these ocular conditions [18].
Better healing of corneal damage with solcoseryl
In a controlled, double-blind study involving 61 patients with corneal injuries, 'solcoseryl Eye-Gel' was tested against 2.4% cysteine eye gel. The eyes of patients treated with solcoseryl Eye-Gel not only healed faster, but were also less likely to develop a corneal macula temidoj after the healing process was complete [19].
Accelerated corneal healing after foreign body removal with Solcoseryl
A double-blind study evaluated the effect of solcoseril on corneal healing, particularly after foreign body removal. Faster healing could be observed in the solcoseril-treated patients than in the control group. In addition, the solcoseryl-treated group was less likely to develop corneal opacity. The lack of negative side effects associated with the use of solcoseril highlights its potential for effective corneal healing after foreign body removal [20].
Help with chronic dry eye syndrome
Solcoseryl has proven to be a versatile solution for a variety of ocular problems. In a study involving 18 patients with chronic dry eye syndrome, solcoseryl gel proved to be extremely helpful. It not only assisted the healing process of the corneal surface, but also increased the transparency of the cornea. Compared to another treatment, i.e. 2,4% ophthalmic gel with cysteine, solcoseryl showed better efficacy, especially in patients with dry keratitis, due to better tolerability [21].
Good for contact lens wearers with dry eyes
Contact lens wearers often experience discomfort due to dry eyes and associated corneal damage. In a study involving contact lens wearers with dry eyes, of the 66 participants, those who added solcoseryl to their treatment along with Corneregel saw significant benefits. Within seven to 14 days, many noticed healing of the cornea. For those with more advanced damage, the introduction of solcoseryl further improved the cornea, providing additional comfort for lens wearers. This combination not only resulted in regeneration of the corneal surface, but also had a positive effect on the anterior layer of the eye, providing both health and comfort for lens wearers [22].
Help with cases of vascular problems in the eyes
For people with vascular problems in their eyes, solcoseryl may prove to be a saviour. In a scientific study spanning more than 17 years with 2331 patients, solcoseryl treatment led to increased visual function, better retinal blood vessel function, and provided lasting improvement. Impressively, the recovery time for patients receiving solcoserol treatment is reduced [23].
Summary
In each of these cases, solcoseryl is shown to be a helpful treatment for a variety of ocular problems, helping to improve patients' vision and overall wellbeing.
Solcoseryl for cardiovascular health
Solcoseryl shows potential in improving cardiovascular health. A number of studies have shown the beneficial effects of solcoseryl in patients dealing with a variety of cardiovascular conditions. These range from aiding recovery after heart attacks to treating peripheral vascular disease. The formulation has demonstrated efficacy and a potential role in comprehensive cardiac care.
Faster recovery after a heart attack thanks to Solcoseryl
In a study involving 58 patients with acute myocardial infarction, solcoseryl was used to assess its effect on recovery. The results were promising: patients treated with solcoseryl reported fewer episodes of angina, suggesting a reduction in heart pain. Those treated with solcoseryl showed faster recovery from CHF symptoms and improved ability to perform physical activity [24].
Calf's blood dialysate (Solcoseryl/Actovegin) after myocardial infarction
In another study involving 60 people after myocardial infarction, calf blood dialysate (solcoseryl/Actovegin) reduced levels of specific enzymes in their blood, such as creatine kinase and aspartate aminotransferase, where both indicate a reduction in cardiac damage. This suggests that calf blood dialysate may offer some potential cardiovascular benefits [25].
Solcoseryl in a multidirectional approach to the treatment of chronic heart disease
Patients with chronic coronary heart disease (CHD) may benefit from a therapeutic approach involving solcoseryl. In a large study involving 349 CHD patients, therapies combining He-Ne laser radiation, alpha-tocopheryl acetate and solcoseryl were used. Results indicated that solcoseryl, in combination with these therapies, significantly relieved pain and improved exercise tolerance. Importantly, the formulation also showed significant efficacy against arrhythmias, highlighting its potential role in the comprehensive treatment of heart disease [26].
The effect of Solcoseryl on atherosclerosis
For people with chronic lower limb atherosclerosis, calf blood dialysate may offer hope. A study of 158 such patients revealed that as many as 93% experienced an improvement in quality of life, sustained for at least six months, following treatment with solcoserol. Additionally, in the intervals between treatment cycles, minimal doses of aspirin and nicotinic acid proved effective as maintenance therapy [27].
Treatment of peripheral vascular disease with Solcoseryl
Peripheral vascular disease is a serious vascular disorder. The condition of patients with this illness improved significantly after treatment with solcoseryl. Not only did the symptoms and visible signs of the disease improve, but also the oxygen level, previously lowered due to the illness. There was also an increase in the difference between arterial and venous oxygen levels. Lactic acid levels decreased, indicating the role of solcoseryl in improving oxygen transport and utilisation, especially in areas affected by the disease [28].
The potential of Solcoseryl in the treatment of ulcers
Shortened treatment time for ulcers with Aevitum and Solcoseryl
A large study involving 105 patients with peptic ulcers used a combination of aevitum and solcoseryl. The methods of administration of solcoseryl varied, but the group receiving direct injections experienced a rapid healing process, with their ulcers completely healed in just 10-12 days, a significant breakthrough [29].
Reduced healing time and frequency of relapses with Solcoseryl and Statizol
Another study, on 300 ulcer patients, used a combination of solcoseril and 'statisol'. The results were promising, cutting the healing time in half and significantly reducing the frequency of ulcer recurrence. The recurrence rate was much lower in the group receiving this combined treatment compared to the control group [30].
Faster recovery from ulcer surgery with Solcoseryl
Patients undergoing ulcer surgery and receiving solcoseryl by injection experienced earlier relief from pain, reduced inflammation and smoother recovery. Additionally, they were able to be discharged from hospital 3-5 days earlier than expected, reducing the cost of their stay and speeding up their return to normal life [31].
Solcoseryl appears to have an important role in reducing healing time and ulcer recurrence, which is a promising prospect for sufferers.
Improved healing in rats with solcoseryl and cycloferon
Experimental studies in male rats showed that the combination of solcoseryl with cyclophosphate, an interferon inducer, had promising healing properties. Rats treated with this combination showed better healing of duodenal ulcers compared to those treated with each drug alone [32]. These results suggest the potential of solcoseryl in ulcer management, especially when used in combination with other drugs.
Oral health benefits
Accelerating the healing of oral wounds
The researchers used a unique dental film, Diplan-denta C, containing solcoseryl, to accelerate healing of surgical wounds on the inside of the cheek. Comparing this to conventional treatments, Diplan-denta C film accelerated the healing of buccal mucosal injuries, suggesting a potential role for solcoseryl in the healing process [33].
Support for patients with hypertension
A study investigated how 'solcoseryl-Denta' cream supports hypertensive patients undergoing oral prosthetic procedures. The use of the cream accelerated the healing of the oral mucosa, which significantly reduced the risk of complications after the procedure [34]. This suggests that solcoseryl may play a role in improving oral health, particularly for patients undergoing dental procedures.
Solution for severe gum disease
In a study with people suffering from a severe form of gum disease, solcoseryl was injected into the gums, which showed promising results. There was a significant reduction in inflammation, bleeding and fluid in specific areas of the gums. Although it did not significantly affect tooth mobility or pocket depth, this suggests that the substance may have a beneficial effect on symptoms associated with severe gum disease [35].
Pain-free recovery after gum surgery
For some bridgework, Solcoseryl Dental Adhesive Paste has proven to be a key element in post-operative care, enabling pain-free recovery [36].
Preventing dry socket after tooth extraction
A study using a combination of gelatine and solcoseryl after tooth extraction aimed to counteract 'dry alveolus', a painful postoperative condition. The group treated with the preparation recorded a significant reduction in the number of cases of dry alveolus, suggesting a potential role for the substance in preventing this painful post-extraction complication [37].
Musculoskeletal benefits
Solcoseryl also appears to have musculoskeletal benefits, particularly for bone health and joint pain relief.
Femoral stem augmentation
A study in young rats suggests that solcoseryl may influence the strength of the femur, increasing bone strength. Additionally, it appears to counteract the debilitating effects of some drugs, highlighting its potential role as a bone-strengthening substance [38].
Pain relief in the course of knee osteoarthritis
In a study on patients with knee osteoarthrosis, injections of solcoseryl/actovegin directly into the knee joints resulted in a decrease in pain. Patients experienced an average decrease in VAS scores and an average reduction in pain scores. The lack of reported side effects suggests that this treatment may not only be effective, but also safe. Nevertheless, further studies are needed to confirm these promising results [39].
Improving bone formation around dental implants
The process of osseointegration is crucial for the successful placement of dental implants. There has been some interesting research into the potential role of solcoseryl in this area. Conducted on rabbits, the study focused on combining calf blood dialysate with a capacitively coupled electric field (CCEF) technique, with the aim of investigating the possibility of increasing bone growth around dental implants. The results are promising, as bone formation and strength in the implant area were significantly improved using both solcoseril and CCEF. These results suggest that the combination of these two treatments can significantly improve the success of dental implants [40].
Based on these observations, it appears that solcoseryl may play a key role in promoting musculoskeletal health. Its potential not only to strengthen bone, but also to alleviate joint pain and improve the effectiveness of dental implants makes it a versatile ingredient in the field of orthopaedic and dental therapy.
Solcoseryl in the treatment of various medical conditions
Scientific research demonstrates the potential of solcoseryl in the treatment of a variety of medical conditions, from lower limb preganglion to severe head injuries. Its diverse mechanisms of action include improving chemical processes in the body, reducing inflammation, promoting tissue healing and potentially protecting against tissue damage.
Treatment of lower limb pre-angina
Gangrene, resulting from ischaemia and infection, poses a serious threat to the body's tissues. In the study conducted - solcoseryl applied topically to the affected areas accelerated the healing process and aided the regeneration of tissues affected by gangrene. The results were promising, with the group using solcoseryl achieving significantly better results compared to the placebo group. The treatment showed efficacy through noticeable improvements in the early symptoms of gangrene, such as skin colour changes, pain and swelling in the lower limbs [41].
Support for severe head injuries
Solcoseryl has been used in cases of severe head injury, particularly closed craniocerebral trauma. Administered intravenously in combination with antioxidant therapy, it acted by increasing oxygen utilisation in damaged brain tissue. In combination with antioxidants, the drug directly affected inflammatory processes, resulting in significant patient benefits such as improved neurological status and blood pressure stabilisation [42].
Helping to treat leg ulcers in patients with sickle cell anaemia
Sickle cell anaemia is characterised by distorted red blood cell morphology, which can lead to various complications, including ulcers. A study conducted on patients with sickle cell anaemia showed that topical application of solcoseryl to ulcers resulted in visible healing. The mechanism of action of solcoseryl, based on the promotion of cellular regeneration and wound healing, contributed to a significant improvement in patients with this disease [43].
Potential in the treatment of chronic bronchitis
For patients with chronic bronchitis, the combination of solcoseryl with other treatments has shown efficacy in improving symptoms and certain biochemical markers associated with the disease. Acting by increasing oxygen delivery and utilisation in the lungs, solcoseryl contributed to symptom relief and made positive changes in biochemical markers associated with chronic bronchitis. These results suggest the potential of solcoseryl to increase the efficacy of the overall treatment of bronchitis [44].
Protection against liver damage
Liver damage can lead to serious conditions such as liver fibrosis or cancer. In a study on protection against liver damage, a protein-free calf blood extract (solcoseryl/actovegin) was presumably administered orally to mice. The results suggest that this compound protects cells and promotes liver cell regeneration, highlighting its potential benefits in liver protection in humans as well [45].
Positive effects in late pregnancy
In cases of chronic placental insufficiency in late pregnancy, solcoseryl has shown the potential to increase estrogen excretion, a key hormone during pregnancy [46]. Intake of solcoseryl intravenously or orally, tailored to the stage of pregnancy and the degree of placental insufficiency, led to a significant increase in estrogen secretion, which may be crucial in maintaining a healthy pregnancy [46].
Management of chronic placental insufficiency
In the case of chronic placental insufficiency, which can lead to insufficient blood flow to the fetus, solcoseryl administered intravenously helped to increase placental blood flow, which assisted in the delivery of nutrients. Dosing was adjusted according to the progression of the pregnancy and the degree of insufficiency. The results suggest that the use of solcoseryl may improve placental function, which is important in maintaining a healthy pregnancy [47].
Oxidative stress management in pregnancy complications
Oxidative stress in pregnancy complications can adversely affect maternal and child health. Solcoseryl, administered orally or intravenously in pregnant women with a diagnosis of intrauterine growth retardation (IUGR), was used to manage oxidative stress. Dosage was adjusted according to the diagnosis and degree of IUGR. Solcoseryl balances oxidative processes, which led to a significant reduction in oxidative stress markers in pregnant women with IUGR [48].
Possible mechanisms of action of solcoseryl
Solcoseryl exhibits a complex mechanism of action, rendering it a versatile therapeutic agent applicable across a range of medical conditions. Derived from a protein-free haemodialysate, its primary function involves enhancing tissue regeneration and improving cellular oxygen utilisation.
Neurological status
Solcoseryl helps to minimise permanent damage from brain haemorrhages.
Modulates central nervous system activity, improving outcomes in cerebrovascular disease.
Reduces the risk of disease progression and transient ischaemic attacks.
Positively influences learning and memory in animal models.
Digestive system healing
Effective in accelerating epithelial cell regeneration in corneal injuries, gingival wounds and deep wounds.
Cardiovascular health and peripheral vascular disease
Contributes to improved haemodynamics.
Supports faster recovery from circulatory failure.
Interaction with other treatments
Increases interferon responses.
Supports antioxidant defence.
Applications in wound care
Effective in accelerating epithelial cell regeneration in various types of wounds.
Regulation of gene expression and signalling pathways
Increases the expression of specific genes and intracellular signalling pathways.
Summary
Solcoseryl appears to be a versatile drug with a wide range of applications, covering different areas of medicine. Research suggests that it may have benefits in improving brain function, accelerating wound healing, supporting eye health, and positively impacting heart health. It is a substance that appears to have the potential to help in many different areas of health, making it a broad-spectrum tool in medical practice.
Disclaimer
This article has been written for educational purposes and is intended to raise awareness of the substance under discussion. It is important to note that the article is about the substance in general - it is not a description of a specific product (chemical reagent). We do not suggest using chemical reagents on humans - this is prohibited by law. For a product to be used for treatment, it must be registered as a medicine. The information contained in the text is based on available scientific research and is not intended as medical advice or to promote self-medication. The reader should consult a qualified health professional for all health and treatment decisions.
References
- Dziak, L. A., & Golik, V. A. (2001). Opyt primeneniia „Solkoserila” v lechenii bol’nykh s tserebral’nym krovoizliianiem [Experience gained with Solcoseryl as treatment of patients with cerebral haemorrhage]. Likars'ka sprava, (4), 162–168. https://pubmed.ncbi.nlm.nih.gov/11692704/
- Bouletreau, P., Petit, P., & Motin, J. (1976). Stress ulcer and acute postoperative renal insufficiency. Attempt at preventive treatment with Solcoseryl and proglumide. Annals of French Anaesthesiology, 17(5), 585–590. https://pubmed.ncbi.nlm.nih.gov/10798/
- Braszko, J. J., Winnicka, M. M., & Wiśniewski, K. (1996). Solcoseryl stimulates behavioural activity of rats. Acta Physiologica Hungarica, 84(1), 63–72. https://pubmed.ncbi.nlm.nih.gov/8993676/
- Winnicka, M. M., Braszko, J. J., & Wiśniewski, K. (1996). Solcoseryl improves learning and memory in rats. Acta Physiologica Hungarica, 84(1), 55–62. https://pubmed.ncbi.nlm.nih.gov/8993675/
- Wang, Y. M., Gao, J. H., Yu, X. C., Wang, S. X., & Wang, H. X. (2009). Acupuncture Research, 34(1), 9–12. https://pubmed.ncbi.nlm.nih.gov/19526800/
- Rudenko, A. Iu., & Bashkirova, L. M. (2003). Solcoseryl—a new means of pathogenetic treatment for patients with paroxysmal conditions in cerebrovascular pathology. Likars'ka sprava, (7), 110–113. https://pubmed.ncbi.nlm.nih.gov/14723151/
- Kurako, I. L., Gertsev, N. F., Gertsev, V. N., Vishnevskiĭ, V. S., Stoianov, A. N., & Chemeresiuk, I. G. (2004). Preliminary data on low-dose Solcoseryl in dyscirculatory encephalopathy. Likars'ka sprava, (1), 79–80. https://pubmed.ncbi.nlm.nih.gov/17051721/
- Chukanova, E. I., & Bogolepova, A. N. (2007). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, Suppl 21, 57–64. https://pubmed.ncbi.nlm.nih.gov/18927981/
- Nam, S. M., & Maeng, Y. S. (2019). Wound healing and mucin gene expression of human corneal epithelial cells treated with deproteinised extract of calf blood. Current Eye Research, 44(11), 1181–1188. https://doi.org/10.1080/02713683.2019.1633360
- Studer, O. (1984). Solcoseryl Eye-Gel vs Cysteine Eye-Gel in corneal injuries. Ophthalmic Research, 16(3), 179–184. https://doi.org/10.1159/000265314
- Dymkowska, W., & Malarewicz, A. (1980). Fluorescence microscopy in gingival wound healing. Dentistry of the GDR, 30(4), 261–269. https://pubmed.ncbi.nlm.nih.gov/6161451/
- Wilmink, J. M., Stolk, P. W., van Weeren, P. R., & Barneveld, A. (2000). Solcoseryl in equine wound healing. Journal of Veterinary Medicine A, 47(5), 311–320. https://doi.org/10.1046/j.1439-0442.2000.00287.x
- Imran, H., Ahmad, M., Rahman, A., Yaqeen, Z., Sohail, T., Fatima, N., Iqbal, W., & Yaqeen, S. (2015). Wound healing comparison with Salvadora persica. Pakistan Journal of Pharmaceutical Sciences, 28(5), 1777–1780. https://pubmed.ncbi.nlm.nih.gov/26408876/
- Abakarova, D. S. (2004). Solcoseryl film in oral mucosal injury. Dentistry, 83(4), 33–36. https://pubmed.ncbi.nlm.nih.gov/15340302/
- Pavliuk, B., Stechyshyn, I., Kramar, S., Chubka, M., & Hroshovyi, T. (2021). Burn wound regeneration with gel. Polish Medical Mercury, 49(293), 352–355. https://pubmed.ncbi.nlm.nih.gov/34800022/
- Miyaji, H., Sakurai, H., Kikawada, M., et al. (2005). Japanese Journal of Geriatrics, 42(1), 90–98. https://doi.org/10.3143/geriatrics.42.90
- Ibishov, K. G. (1999). Ultrasonic abdominal cleansing in gunshot wounds. Vestnik Khirurgii, 158(2), 40–42. https://pubmed.ncbi.nlm.nih.gov/10368889/
- Krannig, H. M., Rohde-Germann, H., & Straub, W. (1989). Therapy of corneal erosions. Ophthalmology, 199(2–3), 100–105. https://doi.org/10.1159/000310024
- Erbe, W., Herrmann, R., Körner, W. F., et al. (1984). Solcoseryl Eye-Gel in corneal lesions. Ophthalmology, 188(1), 1–4. https://doi.org/10.1159/000309336
- Haydon, P. (1983). Solcoseryl gel with antibiotics in corneal healing. Clinical Monthly Bulletins for Ophthalmology, 183(3), 213–216. https://doi.org/10.1055/s-2008-1054907
- Krzystkowa, K. M., Hydzikowa, M., & Szpytma, R. (1991). Solcoseryl ophthalmic gel trial. Eye Clinic, 93(6), 162–163. https://pubmed.ncbi.nlm.nih.gov/1942917/
- Egorova, G. B., Mitichkina, T. S., & Shamsudinova, A. R. (2014). Vestnik of ophthalmology, 130(2), 59–67. https://pubmed.ncbi.nlm.nih.gov/24864502/
- Eliseeva, E. G., Vorob’eva, O. K., & Astaf’eva, N. V. (1999). Fundus vascular pathology treatment. Vestnik of ophthalmology, 115(6), 37–38. https://pubmed.ncbi.nlm.nih.gov/10665289/
- Leshchinskiĭ, L. A., Pimenov, L. T., Kalinina, S. A., & Kolodkin, D. E. (1990). Solcoseryl in myocardial infarction. Cardiology, 30(4), 37–40. https://pubmed.ncbi.nlm.nih.gov/2203929/
- Moczurad, K. W., Weiner, M., & Król, W. (1992). Calf blood dialysate in myocardial infarction. Clinical Trials and Meta-Analysis, 28(1), 13–21. https://pubmed.ncbi.nlm.nih.gov/10148188/
- Luk'ianov, Iu. V., et al. (2000). Solcoseryl in arteriosclerosis obliterans. Vestnik Khirurgii, 159(3), 81–84. https://pubmed.ncbi.nlm.nih.gov/10983350/
- Rossano, C., Weiner, M., & Haigis, E. (1990). Peripheral vascular disease treatment. Arzneimittel-Forschung, 40(11), 1195–1200. https://pubmed.ncbi.nlm.nih.gov/2085330/
- Granov, A. M., et al. (1989). Gastroduodenal ulcer treatment. Vestnik Khirurgii, 144(12), 12–15. https://pubmed.ncbi.nlm.nih.gov/2700609/
- Tsarev, N. I., & Krasnykh, A. M. (1989). Endoscopic ulcer therapy. Vestnik Khirurgii, 142(3), 28–31. https://pubmed.ncbi.nlm.nih.gov/2665305/
- Fomin, P. D., et al. (1998). Solcoseryl after ulcer surgery. Clinical Surgery, (12), 6–8. https://pubmed.ncbi.nlm.nih.gov/10077934/
- Bul’on, V. V., et al. (2001). Cycloferon in duodenal ulcers. Experimental and Clinical Pharmacology, 64(6), 41–44. https://pubmed.ncbi.nlm.nih.gov/11871237/
- Jedrzejewska, T., Bałczewska, E., Peterson, R., Urbaniak, B., & Ostrowska, B. (1990). Periodontal disease treatment. Dental Journal, 43(6), 366–370. https://pubmed.ncbi.nlm.nih.gov/2104369/
- Bakalian, V. L. (2009). Georgian Medical News, (172–173), 39–42. https://pubmed.ncbi.nlm.nih.gov/19644187/
- Schatz, J. P., Fiore-Donno, G., & Henning, G. (1987). Fibrinolytic alveolitis prevention. International Journal of Oral and Maxillofacial Surgery, 16(2), 175–183. https://doi.org/10.1016/s0901-5027(87)80127-3
- Nadulska, A., Klukowska, L., & Dyba, S. (2000). Bone strength study in rats. Annales UMCS Medicine, 55, 189–192. http://bc.umcs.pl/Content/43265/czas4054_55_2000_29.pdf
- Kuptniratsaikul, V., & Kuptniratsaikul, S. (2004). Intra-articular injection in osteoarthritis. Journal of the Medical Association of Thailand, 87(1), 100–105. https://pubmed.ncbi.nlm.nih.gov/14971542/
- Ochi, M., Wang, P. L., Ohura, K., et al. (2003). Bone formation around implants. Clinical Oral Implants Research, 14(3), 294–302.